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Guanidine hydrochloride/6-aza-2-thiothymine-gold nanocluster and preparation method thereof

A technology of thiothymine and gold nanoclusters, which is applied in the nanometer field, can solve the problems of low fluorescence quantum yield and lack of in-depth relationship between fluorescence and composition/structure, and achieve high fluorescence quantum yield, narrow emission spectrum, Excitation spectrum broad effect

Active Publication Date: 2018-06-22
FUJIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Although there has been some research and application of gold nanocluster materials, there is still a lack of in-depth and systematic research on the relationship between its fluorescence and composition / structure.
In addition, most of the fluorescence quantum yields of gold nanoclusters reported now are low (less than 10%), and it is urgent to find a method for the synthesis of fluorescent gold nanoclusters with high quantum yields.

Method used

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  • Guanidine hydrochloride/6-aza-2-thiothymine-gold nanocluster and preparation method thereof
  • Guanidine hydrochloride/6-aza-2-thiothymine-gold nanocluster and preparation method thereof
  • Guanidine hydrochloride/6-aza-2-thiothymine-gold nanocluster and preparation method thereof

Examples

Experimental program
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Effect test

example 1

[0027] 6-aza-2-thiothymine with a concentration of 80 mmol / L (containing 0.2 mol / L sodium hydroxide) and chloroauric acid solution with a concentration of 10 mg / mL were mixed uniformly in a volume ratio of 1:1. After magnetic stirring for 1 hour, a dialysis bag with a molecular weight cutoff (MW) of 3500 was dialyzed in deionized water for 24 hours to obtain a 6-aza-2-thiothymine-gold nanocluster solution.

example 2

[0029] Add 2 mL of guanidine hydrochloride solution (pH=10) with a concentration of 0.01-80 mmol / L into 18 mL of the 6-aza-2-thiothymine-gold nanocluster solution prepared in Example 1, and place Incubate in a water bath at 37°C for 20 minutes to obtain ultra-bright water-soluble guanidine hydrochloride / 6-aza-2-thiothymine-gold nanoclusters. Such as figure 1 Shown, the fluorescence intensity value of the solution at 530 nm (F 530 ) reached the maximum when the concentration of guanidine hydrochloride solution was 40 mmol / L.

example 3

[0031] Add 2 mL of 40 mmol / L guanidine hydrochloride solution (pH=10) into 18 mL of the 6-aza-2-thiothymine-gold nanocluster solution prepared in Example 1, and place at 37 Incubate in a water bath at ℃ for 1-32 minutes to obtain guanidine hydrochloride / 6-aza-2-thiothymine-gold nanoclusters. Such as figure 2 Shown, the fluorescence intensity value of the solution F 530 It stabilized after a reaction time of 20 minutes.

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Abstract

The invention discloses a guanidine hydrochloride / 6-aza-2-sulfo-thymine-gold nano cluster and a preparation method thereof. A 6-aza-2-sulfo-thymine-gold nano cluster is adopted as a precursor, guanidine hydrochloride is adopted as a ligand rigidization agent, and a superbright water-soluble gold nano cluster fluorescent material is obtained through synthesis. The preparation method of the novel gold nano cluster fluorescent material has the advantages of being fast to prepare, simple, environmentally friendly and the like. The synthesized guanidine hydrochloride / 6-aza-2-sulfo-thymine-gold nano cluster emits strong green fluorescence (the maximum emitting wave length is 530 nm), and the prominent advantages of being high in quantum yield (71%), wide in excitation spectrum, narrow in emitting spectrum, good in water solubility and the like are achieved.

Description

technical field [0001] The invention relates to a guanidine hydrochloride / 6-aza-2-thiothymine-gold nano-cluster fluorescent material and a preparation method thereof, belonging to the field of nanotechnology. Background technique [0002] Atomic cluster chemistry is one of the most cutting-edge fields in current material science, organometallic chemistry and other disciplines. The so-called cluster is a kind of atomic cluster compound with a core of 3 or more atoms directly bonded, surrounded by a layer of small organic molecules, also known as a single-layer protective cluster. In recent years, metal nanoclusters, especially gold nanoclusters (AuNCs), have attracted much attention as a new class of fluorescent nanomaterials. Since the size of metal nanoclusters is close to the Fermi wavelength of electrons, the continuous energy state property splits into discrete energy states, and molecular-like size-dependent effects appear. Compared with small molecule organic fluores...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/58C09K11/02
CPCC09K11/025C09K11/58
Inventor 陈伟邓豪华施小琼唐淑榕李光文
Owner FUJIAN MEDICAL UNIV
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