Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Preparation method and application of fe3o4@sio2 egg yolk-eggshell hollow composite microspheres

A technology of composite microspheres and eggshells, applied in the field of biomedical materials, can solve the problems of unfavorable magnetic particle distribution, affecting bearing capacity, reducing biocompatibility, etc., achieving good drug release performance and ensuring the effect of high dispersibility

Inactive Publication Date: 2018-10-23
HENAN UNIVERSITY
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, because the magnetic particles themselves are magnetic, they are easy to agglomerate, which is not conducive to the distribution of magnetic particles in the body.
Now, the common way to reduce agglomeration is to add surfactants, but this method not only changes the surface properties of the particles and affects their load-carrying capacity, but also reduces the biocompatibility due to the presence of surfactants

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of fe3o4@sio2 egg yolk-eggshell hollow composite microspheres
  • Preparation method and application of fe3o4@sio2 egg yolk-eggshell hollow composite microspheres
  • Preparation method and application of fe3o4@sio2 egg yolk-eggshell hollow composite microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] a kind of Fe 3 o 4 @SiO 2 The preparation method of egg yolk-eggshell structure hollow composite microspheres comprises the following steps: ① FeCl 3 •6H 2 O, urea, and trisodium citrate were added to water and stirred to dissolve, then sodium polyacrylate was added, stirred evenly, transferred to a reaction kettle, hydrothermally reacted at 190°C for 3.5h, cooled to room temperature, and the obtained orange-yellow solid was washed with ethanol washed, washed with water, and then dried at 60°C to obtain Fe 2 o 3 Nano microspheres; ② the Fe prepared by step ① 2 o 3 Nanospheres were dispersed into 60vol% ethanol at a solid-to-liquid ratio of 1:250, added with ethanol solution of TEOS (tetraethyl orthosilicate), ultrasonically treated at 25°C for 3 hours, then ammonia water was added, stirred for 3 minutes, and reacted at room temperature for 2 hours. The obtained solid was washed with ethanol, then washed with water, and then dried at 60°C to obtain Fe 2 o 3 @SiO...

Embodiment 2

[0041] a kind of Fe 3 o 4 @SiO 2 The preparation method of egg yolk-eggshell structure hollow composite microspheres comprises the following steps: ① FeCl 3 •6H 2 O, urea, and trisodium citrate were added to water and stirred to dissolve, then sodium polyacrylate was added, stirred evenly, transferred to a reaction kettle, hydrothermally reacted at 170°C for 3 hours, cooled to room temperature, and the obtained orange-yellow solid was washed with ethanol , then washed with water, and then dried at 55°C to obtain Fe 2 o 3 Nano microspheres; ② the Fe prepared by step ① 2 o 3 Disperse the nanospheres in 90vol% ethanol according to the solid-to-liquid ratio of 1g:200ml, add TEOS (tetraethyl orthosilicate) ethanol solution, ultrasonically treat for 4h at 20°C, then add ammonia water, stir for 1min, and react at room temperature for 3h. The resulting solid was washed with ethanol, washed with water, and then dried at 65°C to obtain Fe 2 o 3 @SiO 2 Composite microspheres; ③...

Embodiment 3

[0046] a kind of Fe 3 o 4 @SiO 2 The preparation method of egg yolk-eggshell structure hollow composite microspheres comprises the following steps: ① FeCl 3 •6H 2 O, urea, and trisodium citrate were added to water and stirred to dissolve, then sodium polyacrylate was added, stirred evenly, transferred to a reaction kettle, hydrothermally reacted at 200°C for 6 hours, cooled to room temperature, and the obtained orange-yellow solid was washed with ethanol , then washed with water, and then dried at 65°C to obtain Fe 2 o 3 Nano microspheres; ② the Fe prepared by step ① 2 o 3 Disperse the nanospheres into 10vol% ethanol according to the solid-to-liquid ratio of 1g:350ml, add TEOS (tetraethyl orthosilicate) ethanol solution, ultrasonically treat at 30°C for 2 hours, then add ammonia water, stir for 5 minutes, and react at room temperature for 1 hour. The obtained solid was washed with ethanol, then washed with water, and then dried at 55°C to obtain Fe 2 o 3 @SiO 2 Compo...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
specific surface areaaaaaaaaaaa
sizeaaaaaaaaaa
Login to View More

Abstract

The invention provides a preparation method and application of a Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere. The preparation method comprises the following steps: preparing Fe2O3 nanoparticles by using a solvothermal method; under the condition that no surfactant is added and TEOS is used as a silicon source, preparing a Fe3O4@SiO2 composite microsphere with controllable morphology under mild conditions by using a combination of a template method and a hydrothermal method; corroding the Fe3O4@SiO2 composite microsphere with hydrochloric acid with a certain concentration so as to obtain a Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere; and carrying out reduction so as to prepare the Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere with superparamagnetism. The prepared Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere has a specific surface area of 173 m<2> / g and drug loading capacity of 139 mg / g; and with doxorubicin hydrochloride as a drug model, the Fe3O4@SiO2 yolk-eggshell-structured hollow composite microsphere has a drug release rate of as high as 68.4% within 72 h in a PBS buffer solution with a pH value of 7.4, so the composite microsphere presents good slow drug release performance.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a Fe 3 o 4 @SiO 2 Preparation method and application of hollow composite microspheres with egg yolk-eggshell structure. Background technique [0002] In recent years, with the continuous development of medical technology, drug sustained and controlled release preparations have gradually become the focus of pharmaceutical research, and the key to drug sustained and controlled release technology is the selection of drug carriers. So far, the widely used carrier materials include polymer carriers, intercalated polymer micelle carriers, dendrimers, liposome carriers and inorganic carriers. Inorganic nanomaterials, such as mesoporous materials, nanotubes, hollow microspheres, etc., are well-known for their good chemical stability, controllable particle shape and size, easy modification of surface and pores, and unique optical, magnetic, and electrical properties. It has gradual...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/704A61K47/04A61P35/00C01G49/08B82Y30/00
CPCA61K9/5078A61K31/704A61K47/02B82Y30/00C01G49/08C01P2002/72C01P2002/82C01P2004/04C01P2004/64
Inventor 王永强程琳郑海红虞勇
Owner HENAN UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com