Novel electret microneedle transdermal drug delivery system

Abstract

The invention relates to the technical field of medicines, in particular to a novel electret microneedle transdermal drug delivery system. The system comprises an isolation layer and a drug-containing pressure-sensitive adhesive layer arranged on the inner side of the isolation layer, wherein an electret layer made from an electret material is arranged on the outer side of the isolation layer; a controlled-release membrane layer is arranged on the inner side of the drug-containing pressure-sensitive adhesive layer; the electret layer, the isolation layer, the drug-containing pressure-sensitive adhesive layer and the controlled-release membrane layer are arranged in sequence from outside to inside to form a reservoir type patch; a microneedle array layer is arranged on the inner side of the reservoir type patch and comprises a microneedle array formed by a plurality of microneedles; each microneedle is 20-50 microns in diameter; and the spacing between every two adjacent microneedles is 1-1.5mm. According to the system, a drug can conveniently penetrate the skin by optimizing microneedle structure and arrangement; and when the system is used, the microneedles act on the skin firstly, the drug quickly penetrates the skin through the needle holes of the microneedles, and the electret layer accelerates drug penetration to achieve a treatment effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a drug delivery system. Background technique [0002] The transdermal drug delivery system refers to a new dosage form that is administered on the surface of the skin so that the drug enters the systemic circulation through the skin at a constant rate or near a constant rate to produce systemic or local therapeutic effects. Its advantages are as follows: drug absorption is not affected by factors such as PH in the digestive tract, food, and transit time; avoids liver over-effect; overcomes adverse reactions caused by excessive blood concentration caused by excessive absorption; sustainable control of drug administration speed, flexible medication etc. [0003] However, the existing transdermal drug delivery systems often have defects such as restrictions on the molecular weight and polarity of the drug, and there are also problems such as difficult control of the drug delivery ...

AI Technical Summary

Problems solved by technology

[0003] However, the existing transdermal drug delivery systems often have defects such as restrictions on the molecular weight and polarity of the drug, and there are also problems such as difficult control of the drug delivery dose and poor air permeability.

[0004] In addition, the existing transdermal drug delivery system also has the disadvantages of slow penetration and insufficient drug utilization.

Images