Pharmaceutical composition of carbenicillin sodium and medical application thereof

A technology of carbenicillin sodium and composition, which is applied in the field of pharmaceutical compositions of carbenicillin sodium, can solve the problems such as no reports on the correlation between carbenicillin sodium and its pharmaceutical composition and sedative and soothe the nerves, and achieve the effect of sedative and soothing. strong effect

Inactive Publication Date: 2016-07-27
陈昊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between carbenicillin sodium and its pharmaceutical composition and sedation and tranquilization

Method used

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  • Pharmaceutical composition of carbenicillin sodium and medical application thereof
  • Pharmaceutical composition of carbenicillin sodium and medical application thereof
  • Pharmaceutical composition of carbenicillin sodium and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0021] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0022] Separation method: (a) Grind Herba sinensis (2kg), extract with 80% ethanol under heat reflux (15L x 3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L x 3 times) ), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a ) in n-butanol extract with D101 type macroporous resin for impurity removal, first elute 8 column volumes with 10% ethanol, then elute 10 column volumes with 70% ethanol, collect 70% eluate, concentrate und...

Embodiment 2

[0025] Embodiment 2: pharmacological action

[0026] 1. Materials and methods

[0027] 1.1 Animals

[0028] Kunming mice, weighing 18-25 g, were bred and provided by the Laboratory Animal Laboratory of China Pharmaceutical University.

[0029] 1.2 Reagents and samples

[0030] Carbenicillin sodium was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1.

[0031] 1.3 Mouse grouping and model preparation

[0032] The mice were randomly divided into 4 groups, 12 in each group, respectively the model control group, the carbenicillin sodium group (40 mg·kg -1 ), compound (I) group (40mg·kg -1 ), carbenicillin sodium and compound (Ⅰ) composition group [20mg·kg -1 Carbenicillin Sodium+20mg·kg -1 Compound (I)], orally administered by gavage.

[0033] 1.4 Pentobarbital Sodium Subthreshold Hypnotic Dose Determination

[0034] 1 hour after intragastric administratio...

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Abstract

The invention discloses a pharmaceutical composition of carbenicillin sodium and medical application thereof. The pharmaceutical composition of the carbenicillin sodium provided by the invention contains the carbenicillin sodium and a natural product compound (I) with a novel structure, wherein when the carbenicillin sodium and the natural product compound (I) are acted independently, the pharmaceutical compositioncan play a role in tranquilizing and allaying excitement; when the carbenicillin sodium and the natural product compound (I) are acted jointly, the tranquilizing and allaying excitement effect is more obvious, and the pharmaceutical composition can be developed to form a medicine with the tranquilizing and allaying excitement effect; compared with the prior art, the pharmaceutical composition of the carbenicillin sodium has outstanding substantive distinguishing features and obvious improvement.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of carbenicillin sodium, in particular to a pharmaceutical composition of carbenicillin sodium and its medical application. Background technique [0002] Carbenicillin Sodium is a drug name for systemic infections caused by other susceptible Enterobacter species. The effect on Gram-positive bacteria is similar to ampicillin but slightly weaker. Enterococci are less sensitive to this product. Ineffective against enzyme-producing Staphylococcus aureus. The antibacterial spectrum against Gram-negative bacteria is wider than that of ampicillin, including Pseudomonas aeruginosa, indole-positive Proteus, some Serratia, some Enterobacter, and some Bacteroides. However, most strains of Pseudomonas aeruginosa have poor sensitivity to this product, and this product has a reliable antibacterial effect only at high concentrations. It also has a certain effect on anaerobic bacter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/08A61K31/366A61K31/43A61P25/20
CPCC07D493/08A61K31/366A61K31/43
Inventor 陈昊
Owner 陈昊
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