Absorbable starch styptic powder, preparation method and applications thereof

Abstract

The invention discloses an absorbable starch styptic powder, and a preparation method thereof. The absorbable starch styptic powder is prepared by the following steps: taking plant origin starch and hydroxyethyl starch as the raw materials, emulsifying and dispersing the starches in span 80, tween 80, and plant oil at a temperature of 45 to 70 DEG C under a pH value of 9 to 10, adding sodium trimetaphosphate to carry out crosslinking, using ethyl acetate to perform extraction and liquid separation, washing the solid by anhydrous ethanol, drying the solid in a baking oven, and performing sterilization to obtain the styptic powder. The styptic powder has a good biocompatibility, can be directly applied to the common bleeding parts, deep bleeding parts, and bleeding parts that are hard to reach through surgery operation, and is simple and convenient to use. Starches are the raw materials of the styptic powder, thus the styptic powder is nontoxic and nonirritant, moreover, the sources of raw materials are wide, the cost is low, the technology is simple and feasible, and thus the styptic powder has a wide clinical application prospect.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and specifically relates to an absorbable starch hemostatic powder and a preparation method thereof. Background technique [0002] War injuries, trauma, emergency treatment, and surgical operations can cause bleeding. This problem needs to be resolved. Normal humans have hemostatic function. A slow and small amount of bleeding can stop bleeding by its own function. However, for various sudden accidents, human arterial bleeding and dirty The body cannot stop bleeding by itself, nor can it be stopped by compression by ordinary hemostatic bandages. If the patient loses too much blood, it may cause shock and even endanger life and health. At present, the commonly used effective hemostasis method is to use biocompatible absorbable materials to hemostasis. It is particularly important to provide a safe, effective, convenient, and low-cost hemostatic material in hemostasis such as surgery and first aid. ...

AI Technical Summary

Problems solved by technology

[0003] At present, the clinically used hemostatic materials mainly include fibrin glue, collagen, gelatin sponge and cellulose hemostatic materials. These materials have achieved good results in animal experiments and clinical applications, but there are also some shortcomings: The raw material is derived from animal tissue, which is a foreign protein, which is prone to rejection and has potential sensitization; gelatin absorbs slowly, generally more than 4 weeks, which will increase the risk of wound infection; cellulose, the human body lacks enzymes to degrade it , the degradation time is long, which may bring side effects such as infection to the patient

At present, the representative starch hemostatic material is Arista hemostatic powder produced in the United States. Although its hemostatic effect is good, it is cross-linked with epichlorohydrin, which is potentially toxic and expensive, which limits its application.