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Application of Herba Ecliptae extract to preparation of anti-osteoporosis multi-target medicines or healthcare products

An Eclipta extract, anti-osteoporosis technology, applied in application, food preparation, drug combination, etc., to achieve the effect of high safety, inhibition of bone resorption, and enhancement of osteoblast differentiation and mineralization

Inactive Publication Date: 2016-07-13
DALIAN MEDICAL UNIVERSITY
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Problems solved by technology

We have found that the extract of Eclipta can inhibit the proliferation and differentiation activity of pre-osteoclast RAW264.7 cells, however, whether the extract of Eclipta can promote bone formation of osteoblasts and bone resorption of osteoclasts at the same time, the development No new anti-osteoporosis drugs have been reported

Method used

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  • Application of Herba Ecliptae extract to preparation of anti-osteoporosis multi-target medicines or healthcare products
  • Application of Herba Ecliptae extract to preparation of anti-osteoporosis multi-target medicines or healthcare products
  • Application of Herba Ecliptae extract to preparation of anti-osteoporosis multi-target medicines or healthcare products

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Embodiment 1

[0026] Material:

[0027] Experimental animals: BALB / c mice, weighing 25-30g, male and female. All were purchased from the Experimental Animal Center of Dalian Medical University.

[0028] The cell line used was mouse preosteoclast RAW264.7, purchased from the Cell Bank of the Type Culture Collection Committee of the Chinese Academy of Sciences (Shanghai), cultured in DMEM (Gibco) containing 10% fetal bovine serum (Hangzhou Sijiqing), 0.05 % trypsin (Solarbio) digestion and passage. Place cells at 37°C, 5% CO 2 , cultured in an incubator with saturated humidity to obtain a medium.

[0029] The preparation method of the extract of Eclipta chinensis is as follows: adding ethanol with a volume fraction of not less than 70% to the medicinal material of Eclipta chinensis, and then using a tissue masher to a uniform state, wherein the obtained extract is obtained by combining the medicinal materials of Eclipta chinensis twice and adding For the total extract of the extract solut...

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Abstract

The invention relates to application of a Herba Ecliptae extract to preparation of anti-osteoporosis multi-target medicines or healthcare products.The Herba Ecliptae extract is obtained by steps: adding Herba Ecliptae to ethanol, using a Waring blender for blending to a uniform state, performing ethanol extraction, separating and collecting extract liquid, subjecting solid to ethanol extraction again, mixing the extract liquid obtained by two times, performing vacuum concentration to obtain an alcohol extract, adding water into the alcohol extract, and ultrasonically heating to realize dissolution; adding petroleum ether into dissolved solution, and collecting a water-phase part; adding ethyl acetate for extracting the water-phase part to obtain an ethyl acetate part, and performing vacuum concentration and drying to obtain the Herba Ecliptae extract.According to experiments, the Herba Ecliptae extract has an evident inhibition effect on bone resorption of osteoclasts, and in a same dosage range, osteogenic differentiation and mineralization of osteoblast precursors and mesenchymal stem cells are promoted, so that the Herba Ecliptae extract has dual-function multi-target functions in bone resorption inhibition and bone formation promotion and has a prospect of being developed into novel anti-osteoporosis medicines.

Description

technical field [0001] The invention relates to the application of an extract of Eclipta eclipta that functions on multiple targets, namely the application of the extract of Eclipta eclipta in the preparation of multi-target drugs for anti-osteoporosis. Background technique [0002] Osteoporosis is a systemic disease characterized by low bone mass and microarchitectural disruption of bone tissue, leading to increased bone fragility and susceptibility to fractures. Osteoporosis ranks 7th among common diseases and frequently-occurring diseases in the world, and it occurs frequently in the elderly. According to expert estimates, the prevalence of osteoporosis in the population over 60 years old in my country is about 50% for women and 20% for men, and there are about 90 million osteoporosis patients. With the increasing aging of our country, the prevention and treatment of osteoporosis has become a major project. Although experts at home and abroad attach great importance to t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P19/10A23L1/29
Inventor 刘艳秋战丽彬马慧鹏
Owner DALIAN MEDICAL UNIVERSITY
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