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A kind of hydrogenated soybean lecithin and its preparation method and application

A technology of soybean lecithin and soybean lecithin, which is applied in chemical instruments and methods, edible phospholipid compositions, applications, etc., can solve the problems of increased production cost and high price, and achieve cost reduction, good controllability, and easy industrial production Effect

Active Publication Date: 2018-01-19
苏州东南药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The price of this processed soybean lecithin is very high. Usually, the price of soybean lecithin containing PC70% is 540 yuan / kg, which greatly increases the production cost.

Method used

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  • A kind of hydrogenated soybean lecithin and its preparation method and application
  • A kind of hydrogenated soybean lecithin and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The pretreatment of embodiment 1 powdery soybean lecithin

[0044] Take 300g of powdered soybean lecithin, add 1200ml of acetone and stir vigorously for 4 hours, filter, repeat three times, the obtained acetone is a brown solution, and the solid is a light yellow powder. Add the above solid to 1200ml of absolute ethanol, stir vigorously for 4 hours, filter, repeat three times, and the obtained ethanol is a light yellow solution. Decolorize the ethanol solution with 20g of activated carbon to obtain a clear light yellow solution, distill it under reduced pressure to obtain a yellow viscous solid; dissolve the solid in 600ml of dichloromethane, slowly add it dropwise to 6000ml of acetone, a large amount of off-white flocculent solid washes out , incline the supernatant, then add 3000ml of acetone and stir evenly, filter to obtain 243g of yellowish powdery soybean lecithin.

Embodiment 2

[0045] Example 2 Methylation of soybean lecithin

[0046] In a 2000ml three-neck flask, drop into 240g of the soybean lecithin obtained by ethanol extraction described in Example 1, add 80g of potassium carbonate respectively; 1000ml of chloroform, 78ml of methyl iodide, and react overnight at 30 degrees. Filter to remove excess potassium carbonate and potassium iodide generated, and then concentrate to dryness to obtain 251 g of brown-yellow dry syrupy solid.

[0047] Above-mentioned reaction, with dimethyl sulfate or formaldehyde as methylation reagent, reaction hardly takes place, therefore select methyl iodide as methylation reagent.

Embodiment 3

[0048] Example 3 Catalytic hydrogenation of soybean lecithin

[0049] Dissolve the above-mentioned obtained solid with 5000ml of absolute ethanol, filter, remove the insoluble matter, add 5.0g of palladium carbon catalyst, seal the reaction kettle, feed hydrogen to 1MPa after argon replacement, at 30 o C reacted for 10 hours.

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Abstract

The invention discloses hydrogenated soybean lecithin.A preparation method includes: using acetone to pulp powdery soybean lecithin, filtering, using alcohol to wash solid, combining alcohol solutions, using activated carbon for decoloring, drying by evaporation, continuing using a dichloromethane / acetone system for purification, methylating a crude product after purification, adding the crude product after methylation into a reaction kettle, adding a solvent and a catalyst in a certain amount, sealing the reaction kettle, and feeding hydrogen to certain pressure; reacting in a heat-collecting-type constant-temperature heating magnetic stirrer at constant temperature for certain time; after reaction is finished, separating a product from the catalyst, removing the solvent, and using a complexation method for purification to obtain the hydrogenated soybean lecithin.The preparation method is suitable for pilot-scale production, and the hydrogenated soybean lecithin prepared by the method can be used as a pharmaceutical excipient to be used in various drugs like injections, tablets and capsules.

Description

technical field [0001] The invention belongs to the field of medical auxiliary materials. It specifically relates to a hydrogenated soybean lecithin as well as its preparation method and application. Background technique [0002] Phospholipids are an important part of biological membranes. Their inherent amphiphilic properties, which are both hydrophilic and lipophilic, enable phospholipids to spontaneously form closed bilayers in aqueous media and become the skeleton of biological membranes. Utilizing this property, a new type of pharmaceutical preparation technology, liposome, has been developed. Liposomes were first discovered by British scholar Bangham when phospholipids were dispersed in water and observed under an electron microscope. In 1971, British Lyman et al. used liposomes as drug carriers. Hydrogenated soybean lecithin is made by extracting high-purity lecithin from soybean lecithin and then developing it through catalytic hydrogenation process. The product i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F9/10A61K47/24
CPCA61K47/24C07F9/10
Inventor 刘海东吉民李锐曹萌宗玺顾惠龙
Owner 苏州东南药业股份有限公司
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