Biocomposite and preparation method thereof

Abstract

The invention discloses a biocomposite for bone defect repair.The biocomposite comprises an effective quantity of traditional Chinese medicine active materials.The traditional Chinese medicine active materials include puerarin, icaritin, genistein, curcumin, naringin, naringenin, resveratrol, and at least one of an extract from pueraria, a horny goat weed extract and a turmeric extract.According to the biocomposite, the traditional Chinese medicine active materials containing specific components are adopted as growth factors promoting bone growth, and are wide in source, low in cost and stable in structure and physicochemical property; the traditional Chinese medicine active materials or microspheres or nanoparticles of the traditional Chinese medicine active materials are uniformly dispersed in a support material and continuously released from the support material when in use, the curative effect is kept at the bone defect part for a long time, and bone growth is promoted.Meanwhile, the invention further discloses a preparation method of the biocomposite and an artificial bone support prepared from the biocomposite.

Description

technical field [0001] The invention relates to a biocomposite material and a preparation method thereof, in particular to a biocomposite material which can be used for bone defect repair and a preparation method thereof. Background technique [0002] Bone defect is a difficult point in orthopedic surgery. Factors leading to bone defects include trauma, loose bone fractures, tumors, and osteonecrosis. Autologous bone transplantation in the current clinical treatment of bone defects increases the chance of additional trauma for patients, and the source is limited. Allogeneic bone grafting avoids the disadvantages of autologous bone, but there are potential infection opportunities and rejection reactions. The use of materials composited with degradable carriers and growth factors for bone defect repair is a current research hotspot, and the most commonly used bone morphogenetic protein (BMP) is a growth and differentiation factor that can be used to promote local bone growth...

AI Technical Summary

Problems solved by technology

Allogeneic bone grafting avoids the disadvantages of autologous bone, but there are potential infection opportunities and rejection reactions

The use of materials composited with degradable carriers and growth factors for bone defect repair is a current research hotspot, and the most commonly used bone morphogenetic protein (BMP) is a growth and differentiation factor that can be used to promote local bone growth, but This protein degrades quickly and requires a large dose to maintain its effect, resulting in high cost; its physical and chemical properties are unstable, and it is difficult to maintain its activity when mixed with other carriers; it stays in the defect area for a short time

Gene therapy is only in the stage of animal experiments due to safety issues, and it cannot be applied clinically at present

[0003] Endogenous growth factors (BMP, IGF-1, and TGF-β, etc.) can be used to promote local bone growth, but this protein degrades quickly and requires a large dose to maintain its effect, resulting in expensive costs; unstable physical and chemical properties, It is difficult to maintain their activity when mixed with other carriers; they are destroyed, degraded or cleared by enzymes, or their activity is inhibited by binding proteins; and the dosage and safety of growth factors are still controversial

[0004] The Chinese patent with the publication number CN1775311A discloses a distributably degradable bioactive implant material containing growth-promoting factors, which consists of medical rapidly degradable polymer components containing growth-promoting factors and medical slowly degradable components containing bionic apatite components. The polymer components are composed of blending or copolymerization. Through the combination of the medical fast-degradable polymer and the medical slow-degradable polymer, the bioactive implant material can realize the characteristics of distributed degradation after it is implanted in the body. Overcome the problems of sudden or slow release of growth-promoting factors and insufficient mechanical strength caused by the uncontrollable degradation rate of biomaterials prepared in the past

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