Pharmaceutical composition for treating cold-dampness diarrhea type calf diarrhea and preparation method thereof
A technology for calf diarrhea and cold-damp diarrhea, which is applied in the direction of drug combination, medical formula, drug delivery, etc., can solve the problems of wet and cold adaptability, nutritional disorders, calf injury, etc., and achieve non-toxic side effects, growth Facilitated, less likely to relapse effect
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Embodiment 1
[0041] Ratio: Magnolia officinalis 10g, Evodia 2g, dried ginger 15g, pepper 6g, psoralen 8g, mulberry 10g, jasmine 10g, big head Chen 8g, grape 10g, white lentils 10g, papaya 8g, Peilan 6g, paicaoxiang 10g, Grass 8g, Fenghancao 10g, Penglu 6g, Cardamom 10g, Tongjingcao 8g, Saxifrage 2g, Shuituanhua 1g and Tengwu 2g.
[0042] Its preparation method is:
[0043] Step 1: Mix the raw medicinal materials according to the stated ratio, add ethanol with an alcohol concentration of 85% that is 5 times that of the mixture, heat to boiling and reflux for 4 hours, filter, and slowly use the percolation method at a rate of 2ml per minute. Percolation, collecting the percolation liquid, then concentrating under reduced pressure at 0.08Mpa to a paste with a relative density of 1.08 at 55°C, spray drying, the inlet air temperature of the spray dryer is 170°C, and the outlet air temperature is 85°C, and then Crushed into powder, made into dry cream powder;
[0044] Step 2: Add 0.3 times of ...
Embodiment 2
[0046] Ratio: Magnolia officinalis 20g, Evodia 4g, dried ginger 20g, Chinese prickly ash 12g, psoralen 13g, mulberry 20g, jasmine 20g, Datouchen 15g, grape 20g, white lentils 15g, papaya 13g, Peilan 12g, paicaoxiang 20g, 15g grass, 15g Fenghancao, 12g pomegranate, 20g cardamom, 12g Tongjingcao, 4g saxifrage, 3g water tuanhua and 4g vine aconitum.
[0047] Its preparation method is:
[0048] The first step is to mix the raw medicinal materials in proportion, add ethanol with an alcohol concentration of 90% that is three times the mass of the mixture, heat and reflux for 2 hours, extract, and filter to obtain the first extract; Add ethanol with an alcohol concentration of 90% that is twice the mass of the dregs, heat and reflux for 3 hours, extract, and filter to obtain a second extract; combine the first extract and the second extract, and concentrate under reduced pressure to remove ethanol solvent, dried to obtain a dry paste;
[0049] In the second step, the dry paste obta...
Embodiment 3
[0052] Ratio: Magnolia officinalis 14g, Evodia 3g, dried ginger 18g, pepper 8g, psoralen 10g, mulberry 16g, jasmine 16g, big head Chen 12g, grape 16g, white lentils 12g, papaya 10g, Peilan 8g, paicaoxiang 15g, fennel Grass 12g, Fenghancao 12g, Pentaphyllum 8g, Cardamom 15g, Tongjingcao 10g, Saxifrage 3g, Shuituanhua 2g and Tengwu 3g.
[0053] Its preparation method is:
[0054] In the first step, the raw medicinal materials are mixed in proportion, put into an ultrafine pulverizer and pulverized into a mixed powder composed of micron-sized particles with a volume average particle size of 1 μm and nano-sized particles with a volume average particle size of less than 0.1 μm , the powder yield of the mixed powder is 97%;
[0055] In the second step, add ethanol with an alcohol concentration of 85% relative to the mass of the mixed powder that is 4 times the mass of the mixed powder obtained in the first step, stir and dissolve to obtain an ethanol solution, and put the ethanol s...
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