Application of domperidone in preparation of therapeutics for cerebral ischemia-reperfusion injury

A technology of cerebral ischemia-reperfusion and domperidone, which is applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of undiscovered domperidone, etc.

Inactive Publication Date: 2016-07-06
李春华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of domperidone for the treatment of cerebral ischemia-reperfusion injury has not been found in the prior art

Method used

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  • Application of domperidone in preparation of therapeutics for cerebral ischemia-reperfusion injury
  • Application of domperidone in preparation of therapeutics for cerebral ischemia-reperfusion injury
  • Application of domperidone in preparation of therapeutics for cerebral ischemia-reperfusion injury

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Experimental program
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Embodiment Construction

[0023] 1 Experimental method

[0024] 1.1 Establishment of MCAO mouse model

[0025] (1) Experimental animals and sources

[0026] 72 male wild-type C57 / BL6 pathogen-free (SPF grade) mice, aged 6-8 weeks, weighing 25-30 g, were kept in a room temperature of 20-25°C and a relative humidity of 40%-60%.

[0027] (2) Experimental grouping

[0028] For studying the drug action of domperidone in mouse MCAO animal model, mice are divided into three groups at random, 24 in every group, are respectively sham operation group; Ischemia-reperfusion model group (model group); Domperidone treatment group (treatment group). ). Domperidone 50 mg / Kg / day was given by intragastric administration to the treatment group and 7 days before the preparation of the MCAO model. The sham operation group and the model group were given intragastric administration of the same volume of normal saline as the treatment group 7 days before the MCAO model preparation. The mice in model group and treatment g...

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PUM

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Abstract

The invention provides an application of domperidone for preparing a medicine for treating cerebral ischemia-reperfusion injury. The present invention finds that domperidone has an outstanding protective effect on cerebral ischemia-reperfusion injury. Specifically, domperidone can improve neurological function loss after cerebral ischemia-reperfusion injury, reduce brain water content, reduce infarct volume, and increase peroxidation. It can reduce the content of malondialdehyde and reduce the expression of inflammatory factors such as IL-1 and IL-6, so as to reduce the excessive inflammatory response of ischemic brain tissue and realize the neuroprotective effect after ischemia. The present invention determines the exact curative effect, effective dose and administration method of domperidone for treating cerebral ischemia-reperfusion injury through a large amount of experimental data, and provides a new approach for the treatment of cerebral ischemia-reperfusion injury.

Description

technical field [0001] The present invention relates to a new application of the compound domperidone, in particular to the application of domperidone in the preparation of drugs for the treatment of cerebral ischemia-reperfusion injury Background technique [0002] Cerebrovascular disease is one of the three major diseases that cause human death. Its high mortality and disability rate have brought heavy burdens to society and families. The brain is the most sensitive organ of the human body to hypoxia. Brain tissue ischemia (ischemia) will cause damage to local brain tissue and its function. The degree of damage is related to the length of ischemia time and the amount of residual blood flow. Blood only causes reversible damage, while prolonged complete ischemia or severe ischemia can cause infarction. [0003] After brain ischemia, microglia and astrocytes are activated to produce a large number of cytokines and chemokines. Cytokines up-regulate the expression of adhesion...

Claims

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Application Information

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IPC IPC(8): A61K31/454A61P9/10
CPCA61K31/454
Inventor 李春华
Owner 李春华
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