Ceftiofur hydrochloride breast injectant during dry period

Abstract

The invention relates to a formula of a ceftiofur hydrochloride breast injectant during a dry period, and a preparation method of the injectant. The injectant comprises a suspending agent, a thickening agent, a surfactant, and a solid dispersion carrier, and is manufactured into a white or white-like ointment through special process. The injectant is simple to prepare, stable in quality and content, easy to inject, and soft in matrix. The injectant is an ointment, and compared with an injection, the injectant has advantages, such as high bioavailability, slow release, and long action time, can be sealed at nipple holes after being filled into milk chambers through milk ducts, and can prevent bacteria from intruding into the milk chambers by virtue of retrograde motion through the nipples.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a prescription of ceftiofur hydrochloride dry lactation udder injection and a preparation method thereof. Background technique [0002] According to the statistics of the International Dairy Cattle Federation, in the 1970s, the incidence rate of cow mastitis was 20%, and the prevalence rate of recessive mastitis was 50%. In several large cities in my country at the same period, the detection of dairy cows' milk showed that the detection rate of dairy cows' recessive mastitis was 20%-70%. In the 1980s, more than 60% of dairy cows in my country were infected with recessive mastitis, and 30%-50% of the udder area had recessive mastitis. In recent years, with the continuous development of intensive breeding industry, the level of antibiotic prevention and treatment has been further deepened. By implementing strict intramammary antibiotic prevention and teat di...

AI Technical Summary

Problems solved by technology

[0006] The dosage form of "a dried dairy cow udder perfusion agent for preventing and treating dairy cow mastitis and its preparation method (CN1286463C; publication date: September 14, 2005)" is a perfusion agent, and polysorbate is required in the preparation process of the solution. Water, etc., have the disadvantages that the active ingredients are easily damaged after demulsification, require high transportation and storage conditions, and cannot protect the teats of dairy cows, etc.

[0007] "A method for preparing ceftiofur hydrochloride suspension injection (102813623A; publication date: 2012-12-12)", the dosage form of this patent is a suspension, which requires multiple administrations, and the preparation is easy to settle , after being injected into the breast chamber, it is easy to form an excessively high content of the main drug in the local area, and it is easy to form part of the tissue toxic accumulation in the breast

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