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Medicine composition for treating peptic ulcer and preparation method thereof

A peptic ulcer and composition technology, applied in the field of pharmaceutical preparations, can solve the problems of unsatisfactory clinical curative effect, many side effects of antibiotics, easy to produce drug resistance, etc., and achieve protection of gastric mucosa, no toxic side effects, and short treatment period Effect

Inactive Publication Date: 2016-06-22
济南思拓新源医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in Western medicine, the treatment plan is single, the course of treatment is long, the long-term use of antibiotics has more toxic and side effects, and it is easy to produce drug resistance. Long-term use of drugs brings certain psychological pressure to patients, and the clinical efficacy is not ideal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0060] When the dosage form of the pharmaceutical composition is a granule, its preparation method comprises the following steps:

[0061] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add ethanol with an alcohol concentration of 85% to 95% that is 4 to 8 times that of the mixture, heat to boiling and reflux for 3 to 5 hours, and filter. Use the percolation method to percolate slowly at a rate of 1-2ml per minute, collect the percolation liquid, and then concentrate under reduced pressure at a vacuum of 0.06-0.09Mpa to a paste with a relative density of 1.04-1.10 at 50-60°C. Spray drying, the air inlet temperature of the spray dryer is 160-175°C, the outlet air temperature is 80-85°C, and then crushed into powder to make dry paste powder;

[0062] In the second step, 0.2-0.4 times of sucrose powder and 0.1-0.2 times of dextrin are added to the obtained dry paste powder to form granules, and dried at 40-50° C. to obt...

Embodiment 1

[0072] Embodiment 1 Granules

[0073] The preparation process of the granules of the present invention is as follows: get 140g Polygonatum odoratum, 260g medlar, 160g rutabaga, 100g Pteris seven, 240g carrageen, 320g licorice, 200g remnant stalk, 170g dawanhua, 140g cardamom, mist Ge 300g, Gou catecha 150g, Laojunxu 320g, Adenophora ginseng 220g, Gardenia 180g, Tangerine 300g, Shichangpu 140g, Yizhiren 250g, Codonopsis 350g, Gallus gallus 160g, Limonium bicolor 300g and Dioscorea shield leaf 180g;

[0074] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add ethanol with an alcohol concentration of 90% that is 7 times that of the mixture, heat to boiling and reflux for 4 hours, filter, and use the percolation method at a rate of 90% per minute. Slowly percolate at a speed of 2ml, collect the percolation liquid, and then concentrate under reduced pressure at a vacuum of 0.07Mpa to a paste with a relative density of 1.0...

Embodiment 2

[0076] Embodiment 2 capsules

[0077] The preparation process of the capsule of the present invention is as follows: get 180g Polygonatum odoratum, 320g medlar, 200g rutabaga, 120g Pteris chinensis, 230g carrageen, 310g licorice, 250g remnant persimmon, 190g dawanhua, 170g cardamom, mist 260g Ge, 140g Gou Catecha, 310g Laojunxu, 200g Adenophora, 160g Gardenia, 300g Orange White, 150g Shichangpu, 350g Yizhi Kernel, 400g Soil Codonopsis, 200g Chicken Neijin, 320g Two-color Limonium and Dioscorea shield leaf 160g;

[0078] The first step is to mix the raw materials of the pharmaceutical composition in proportion, add ethanol with an alcohol concentration of 85% that is 3 times the mass of the mixture, heat and reflux for 2 hours, extract, and filter to obtain the first extract; Then add ethanol with an alcohol concentration of 90% to the dregs of the dregs, heat and reflux for 3 hours, extract, and filter to obtain the second extract; combine the first extract and the second ext...

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Abstract

The invention discloses a medicine composition for treating peptic ulcer and a preparation method thereof. The medicine composition is prepared from fragrant Solomonseal Rhizome, fructus lycii, hedge prinsepia nuts, roots of Shrubberry Rhodiola, Carageen, liquorice roots, roots or bark of Gluey Litse, rhizome and flowers of Calystegin hederacea Wall., Microcos paniculata Linn, Jave Amonum Fruit, all grass of Pouzolzia zeylanica (L.)Benn., Berchemia sinica Schneid., Loveyly Hemsleya roots, Cynanchum mooreanum Hemsl., CoasiaI GIehnia roots, Cape jasmine, Aleuritopteris, Tangerine white endocarp, Ilex rotunda Thunb., Acorus gramineus, Fructus Alpinae Oxyphyllae, Aristolochia moupinensis Franch. rhizome, roots of Java Campanumoea, membranes of Chicken Gizzard, Limonium bicolor (Bag.) Kuntze and Dioscorea zingiberensis C. H. Wright. The composition has the advantages that the functions of strengthening spleens and stomachs, invigorating spleens, supplementing qi, tonifying stomachs and nourishing yin are achieved, the effects of clearing heat, promoting diuresis, increasing appetite and relieving pain are achieved at the same time, and the composition mainly treats stomach yin asthenia type peptic ulcer, can protect gastric mucosa, effectively improve damp and hot constitutions of patients and regulate immune functions of whole bodies, and has the advantages of being quick in effect, high in effective rate, accurate in treatment effect, free of toxic and side effects, low in price, and the like.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating peptic ulcer and a preparation method thereof. Background technique [0002] Peptic ulcer mainly refers to chronic ulcers that occur in the stomach and duodenum. It is a frequently-occurring disease and a common disease. There are various factors in the formation of ulcers, among which the digestion of mucous membrane by acidic gastric juice is the basic factor in the formation of ulcers, hence the name. Any part in contact with acidic gastric juice, such as the lower esophagus, the anastomotic port after gastrointestinal anastomosis, the jejunum, and Meckel's diverticulum with heterotopic gastric mucosa, the vast majority of ulcers occur in the duodenum and stomach, so they are also called stomach, ten duodenal ulcer. [0003] The etiology and pathogenesis of peptic ulcer in traditional Chinese medicine: The etiol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P1/04A61K35/57
CPCA61K36/8969A61K9/0019A61K9/1652A61K9/19A61K9/4858A61K35/57A61K36/03A61K36/11A61K36/185A61K36/23A61K36/264A61K36/27A61K36/34A61K36/39A61K36/41A61K36/42A61K36/484A61K36/54A61K36/72A61K36/73A61K36/744A61K36/752A61K36/815A61K36/888A61K36/8945A61K36/9062A61K36/9064A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 孙健
Owner 济南思拓新源医药科技有限公司
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