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Dihydrochlorothiazide (DCT) containing pharmaceutical composition for treating hypertension and preparation method thereof

The technology of hydrochlorothiazide and composition is applied in the field of pharmaceutical composition for treating hypertension and its preparation field, which can solve the problems such as restricting the use of hydrochlorothiazide, and achieve the effects of avoiding adverse reactions, improving therapeutic effect and reducing blood pressure

Inactive Publication Date: 2016-06-22
JINAN BANGWEN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This adverse reaction limits the clinical use of hydrochlorothiazide

Method used

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  • Dihydrochlorothiazide (DCT) containing pharmaceutical composition for treating hypertension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0039] Hydrochlorothiazide 25g, Eucommia leaves 3000g, Northeast yew 3000g, golden hair grass 3000g, bluegrass 3000g.

[0040] The preparation method of the pharmaceutical composition for treating hypertension:

[0041]a. Decoct Eucommia leaves, Chinese yew, blond grass, and bluegrass with water for 2 times, add 7 volumes of water for the first time, decoct for 1.5 hours, add 5 times the volume of water for the second time, and decoct 1 hour, combine the decoction liquid and set aside;

[0042] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0043] c. mix hydrochlorothiazide and dry medici...

Embodiment 2

[0047] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0048] Hydrochlorothiazide 20g, Eucommia ulmoides leaves 3500g, Northeast yew 2500g, golden hair grass 3500g, bluegrass 2500g.

[0049] The preparation method of the pharmaceutical composition for treating hypertension:

[0050] a. Add water to decoct Eucommia ulmoides leaves, Northeast yew, blond grass, and bluegrass for 2 times, add 8 volumes of water for the first time, decoct for 2 hours, add water 6 times the volume of the medicine for the second time, and decoct After 1.5 hours, combine the decoction and set aside;

[0051] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0052] c. mi...

Embodiment 3

[0056] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0057] Hydrochlorothiazide 25g, Eucommia ulmoides leaves 2500g, Northeast yew 3500g, golden hair grass 2500g, bluegrass 3500g.

[0058] The preparation method of the pharmaceutical composition for treating hypertension:

[0059] a. Add water to decoct Eucommia ulmoides leaves, Northeast yew, blond grass, and bluegrass for 2 times, add 6 volumes of water for the first time, decoct for 1 hour, add water 4 times the volume of the medicine for the second time, and decoct After 0.5 hours, combine the decoction and set aside;

[0060] b. Concentrate the decoction liquid at 65°C and -0.04Mpa into a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0061] c. mix...

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Abstract

The invention belongs to the technical field of medicines and particularly relates to a dihydrochlorothiazide (DCT) containing pharmaceutical composition for treating hypertension and a preparation method thereof. The DCT containing pharmaceutical composition for treating the hypertension, provided by the invention, is prepared from the following raw pharmaceutical materials in parts by weight: 15-30 parts of DCT, 2,000-4,000 parts of Eucommia ulmoides, 2,000-4,000 parts of Taxus cuspidata, 2,000-4,000 parts of Pogonatherum paniceum and 2,000-4,000 parts of Poa pratensis. According to the DCT containing pharmaceutical composition for treating the hypertension and the preparation method thereof, the traditional Chinese medicines and the DCT are combined, so that common adverse reactions of the DCT can be avoided, and the treatment effect on the hypertension is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing hydrochlorothiazide for treating hypertension and a preparation method thereof. Background technique [0002] Hypertension is an important etiology and risk factor of cardiovascular and cerebrovascular diseases, and 20%-30% of people worldwide suffer from hypertension. High blood pressure can affect the structure and function of the heart, brain, and kidney, and significantly increase the risk of stroke, heart failure, and end-stage renal disease. Essential hypertension accounts for 95% of the incidence of hypertension. The survey in 2002 showed that the prevalence rate of people over the age of 18 in my country was as high as 18.8%, and the number of patients reached 160 million. Therefore, the prevention and treatment of hypertension has become a major public health issue that is of the greatest concern in my country and the...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K31/549A61K9/16A61P9/12
CPCA61K31/549A61K9/1652A61K36/13A61K36/46A61K36/899A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 不公告发明人
Owner JINAN BANGWEN MEDICAL TECH
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