Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Repaglinide and metformin hydrochloride tablet pharmaceutical composition and preparation method thereof

A technology of metformin tablets and metformin, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations of non-active ingredients, etc., can solve problems such as uneven mixing of low-dose drug repaglinide, and achieve rapid dissolution and reduce exposure , the effect of promoting the efficacy of the drug

Active Publication Date: 2016-06-15
CHENGDU EASTON BIOPHARM CO LTD
View PDF6 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The purpose of the present invention is to provide a pharmaceutical composition of repaglinide metformin tablets, under the premise of ensuring product stability, realize the synchronous release of the insoluble drug repaglinide and the water-soluble drug metformin hydrochloride; simultaneously solve the problem of low dosage The problem of uneven mixing of the drug repaglinide

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Repaglinide and metformin hydrochloride tablet pharmaceutical composition and preparation method thereof
  • Repaglinide and metformin hydrochloride tablet pharmaceutical composition and preparation method thereof
  • Repaglinide and metformin hydrochloride tablet pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1: Repaglinide metformin tablet prescription (in 1000 tablets, unit: g):

[0047]

[0048]

[0049] Preparation Process:

[0050] Add 0.2g poloxamer, 0.5g meglumine and 0.6g povidone K30 into an appropriate amount of water, stir to dissolve the materials completely, then slowly add 1g repaglinide, continue stirring to dissolve, and prepare repaglinide solution; take 15g of microcrystalline cellulose particles and place them in the top spray pot of the fluidized bed. 3 / h, the atomization pressure is 1.0Pa, start the liquid supply pump, spray the repaglinide solution into the fluidized bed for granulation, dry after the spraying is completed, and obtain the repaglinide granules; get 500g of metformin hydrochloride, add 16g of povidone K30, 8g of sorbitol, and 4g of polyethylene glycol 6000 were placed in a granulation pot, mixed for 10 minutes, stirred while slowly adding an appropriate amount of water for granulation, and granulated with a sieve plate ...

Embodiment 2

[0051] Embodiment 2: Repaglinide metformin tablet prescription (in 1000 tablets, unit: g):

[0052]

[0053] Preparation Process:

[0054] Add 0.9g poloxamer, 1.0g meglumine and 1.2g povidone K30 into an appropriate amount of water, stir to dissolve the material completely, then slowly add 2g repaglinide, continue stirring to dissolve, and prepare repaglinide solution; take 36g of microcrystalline cellulose particles and place them in the top spray pot of the fluidized bed, set the inlet air temperature at 40-60°C, and the inlet air flow at 60-150 3 / h, the atomization pressure is 1.5Pa, start the liquid supply pump, spray the repaglinide solution into the fluidized bed for granulation, dry after the spraying is completed, and obtain the repaglinide granules; get 500g of metformin hydrochloride, add 22g of povidone K30, 12g of sorbitol, and 6g of polyethylene glycol 6000 were placed in a granulation pot, mixed for 10 minutes, stirred while slowly adding an appropriate amou...

Embodiment 3

[0055] Embodiment 3: Repaglinide metformin tablet prescription (in 1000 tablets, unit: g):

[0056]

[0057] Preparation Process:

[0058] Add 0.9g poloxamer, 1.0g meglumine and 1.2g povidone K30 into an appropriate amount of water, stir to dissolve the materials completely, then slowly add 1g repaglinide, continue stirring to dissolve, and prepare repaglinide solution; take 36g of microcrystalline cellulose particles and place them in the top spray pot of the fluidized bed, set the inlet air temperature at 40-60°C, and the inlet air flow at 60-150 3 / h, the atomization pressure is 2.0Pa, start the liquid supply pump, spray the repaglinide solution into the fluidized bed for granulation, dry after the spraying is completed, and obtain the repaglinide granules; get 500g of metformin hydrochloride, add 20g of povidone K30, 10g of sorbitol, and 5g of polyethylene glycol 6000 were placed in a granulation pot, mixed for 10 minutes, stirred while slowly adding an appropriate amo...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a repaglinide and metformin hydrochloride tablet pharmaceutical composition; in a prescription, the amount of a disintegrating agent is greatly reduced compared with the prior art; in a process, microcrystalline cellulose particles are prepared in advance, repaglinide is made into a solution, repaglinide particles are prepared on the microcrystalline cellulose particles through fluidized bed atomizing, and the repaglinide particles are mixed and tabletted with metformin hydrochloride particles. The prepared repaglinide and metformin hydrochloride tablet product is stable, the insoluble drug repaglinide and the water-soluble drug metformin hydrochloride are both released synchronously according to requirements, and the bioavailability is better compared with that of the prior art; and at the same time, the problem of uneven mixing of the low-dosage drug repaglinide is solved, and the drug efficacy playing is greatly promoted.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a pharmaceutical composition of repaglinide metformin tablets and a preparation method thereof. Background technique [0002] Repaglinide metformin tablets, the main ingredients are repaglinide and metformin hydrochloride. Repaglinide, the chemical name is S(+)-2-ethoxy-4-{2-[(3-methyl-1-(2-(1-piperidinyl)phenyl)butyl)amino ]-2-oxoethyl}benzoic acid, the chemical structural formula is: [0003] [0004] Metformin, its hydrochloride is commonly used clinically, that is, metformin hydrochloride, the chemical name is 1,1-dimethylbiguanide hydrochloride, and its chemical structure is: [0005] [0006] The compound composition of repaglinide and metformin hydrochloride can control the blood sugar level from two different ways. Metformin hydrochloride is a biguanide hypoglycemic drug. By inhibiting hepatic gluconeogenesis, reducing hepatic glucose output...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/451A61K31/155A61K9/20A61K47/38A61K47/32A61P3/10
CPCA61K9/1676A61K9/2077A61K31/155A61K31/451A61K47/32A61K47/38A61K2300/00
Inventor 王颖伍熹黄磊
Owner CHENGDU EASTON BIOPHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com