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Nandina total alkaloid extract and application thereof to preparation of medicine for treating pharyngitis

A technology of total alkaloids and extracts, which is applied in the field of nandina total alkaloids extract, can solve the problems that there are no research reports on nandina treatment of pharyngitis, and achieve the effect of high total effective rate, controllable quality and high purity

Active Publication Date: 2016-06-08
HEFEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern pharmacological studies have shown that nandina has pharmacological effects such as antibacterial, lowering blood pressure, relieving cough, and relieving asthma, but there is no research report on nandina treating pharyngitis

Method used

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  • Nandina total alkaloid extract and application thereof to preparation of medicine for treating pharyngitis
  • Nandina total alkaloid extract and application thereof to preparation of medicine for treating pharyngitis
  • Nandina total alkaloid extract and application thereof to preparation of medicine for treating pharyngitis

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Embodiment 1

[0027]The preparation of embodiment 1 nandina total alkaloid extract

[0028] Take 1.0Kg of nandina root coarse powder, add 10 times the amount (mass ratio) of 75% ethanol (volume ratio), reflux extraction twice, each time for 2 hours, combine the filtrates, and recover ethanol under reduced pressure to obtain final product.

Embodiment 2

[0029] The preparation of embodiment 2 nandina total alkaloid extract

[0030] Take 1.0Kg of nandina stem powder, add 6 times the amount (mass ratio) of 75% ethanol (volume ratio), reflux extraction twice, each time for 2 hours, combine the filtrates, and recover ethanol under reduced pressure to obtain final product.

Embodiment 3

[0031] The preparation of embodiment 3 Nandina total alkaloid extract

[0032] Take 1.0Kg of nandina leaves, add 16 times the amount (mass ratio) of 75% ethanol (volume ratio), percolate at a speed of 20ml / min / Kg medicinal material, collect the percolation liquid, and recover ethanol under reduced pressure to obtain final product.

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Abstract

The invention discloses a nandina total alkaloid extract and application thereof to preparation of medicine for treating pharyngitis, and belongs to the field of preparation and application of the nandina total alkaloid extract. The nandina total alkaloid extract is prepared by extracting smashed nandina raw materials with ethyl alcohol. The concentration of the ethyl alcohol adopted in extraction is optimized, an optimization result indicates that the total effective rate of the nandina total alkaloid extract extracted with the 75% ethyl alcohol on treatment of pharyngitis is highest, and compared with other concentrations, the difference is remarkable. The nandina total alkaloid extract extracted with the ethyl alcohol is further purified, the quality and purity of the nandina total alkaloid extract purified by a macroporous resin column are highest, and the treatment effect on pharyngitis is more remarkable. The nandina total alkaloid extract has a good treatment effect on pharyngitis, and can be applied to preparation of the medicine for treating pharyngitis.

Description

technical field [0001] The invention relates to an extract of total alkaloids of nandina, and also relates to the application of the extract of total alkaloids of nandina in the preparation of medicines for treating pharyngitis, and belongs to the field of preparation and application of the extract of total alkaloids of nandina. Background technique [0002] The incidence of pharyngitis is high and the number of patients is large. It is estimated that the number of β-hemolytic streptococcal pharyngitis in the world exceeds 61.6 million cases per year, accounting for 15% to 30% of pharyngitis cases in children, and mainly affects school-age children; Account for 5%~10% of adult pharyngitis cases, the incidence rate is lower in the crowd over 20 years old, and reasons such as being underestimated easily, often can affect people's health and normal work, life. Whole body toxic reactions such as the acute pharyngitis patient also can occur generating heat, is afraid of cold, hea...

Claims

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Application Information

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IPC IPC(8): A61K36/29A61P11/04
CPCA61K9/2027A61K36/29A61K2236/333A61K2236/51A61K2236/55
Inventor 陈仕云阳杰高雅
Owner HEFEI UNIV
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