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Blood coagulation time test and analysis device

A technology of test analysis and coagulation time, which is applied in the direction of material resistance, can solve the problems of high value of testing equipment, complex testing equipment, and unsatisfactory accuracy, and achieve the effect of reducing testing cost and threshold, simple software and hardware, and high accuracy

Active Publication Date: 2016-06-01
SHANGHAI UPPER BIO TECH PHARMA
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Problems solved by technology

[0005] For the detection of coagulation time in the prior art, the method of detecting the change of the optical properties (degree of light transmission) of the mixture of plasma and reagents, or the method of changing the magnetic properties, and the testing and analysis instruments based on these methods, the above two methods are for blood coagulation The time detection method is not intuitive enough, and the detection equipment is relatively complex, the detection equipment is expensive, and the detection cost is high. At the same time, the monitoring accuracy is often not satisfactory due to equipment or environmental factors

Method used

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  • Blood coagulation time test and analysis device

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Embodiment Construction

[0032] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0033] The principle of the present invention is that whole blood (including blood cells, platelets, and plasma) of the human body can flow in the capillary of a special disposable test piece. The blood coagulates under the action of the prefabricated dry coagulation activator in the test piece, and when the coagulation process is completed, the capillary microflow will stop. The coagulation time is the time from the beginning of blood contact with the reagent to the cessation of blood microflow. A conductive wire is plated in the capillary to measure the change of impedance with time when the fluid passes through the microfluidic channel. Furthermore, the coagulation time can be accurately determined according to the change of impedance with time. This is obtained by following the time profile of the impedance change. The PT reagent is used...

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Abstract

The invention relates to a blood coagulation time test and analysis device which is characterized by comprising a test piece (22) and a portable main machine, wherein a sample hole (1) for containing a blood sample, a reagent hole (2) for containing a reagent and a capillary tube (3) with a conducting layer (5) are formed in the test piece (22); the sample hole (1), the reagent hole (2) and the capillary tube (3) are communicated with one another in sequence; an air hole (4) is formed in the tail end of the test piece (22), so that liquid can flow in the capillary tube (3); the conducting layer (5) is connected with an electrode interface (7); the electrode interface (7) is accessed into the portable main machine; when the blood sample is mixed with the reagent, the mixed liquid flows along the capillary tube (3); along with the flowing of the mixed liquid, the resistance of the conducting layer (5) changes; the portable main machine is used for measuring the time required by blood coagulation through obtaining a resistance change stop time point.

Description

technical field [0001] The invention relates to a coagulation time test and analysis device, in particular to a thrombin time test device, belonging to the technical field of coagulation test and analysis. Background technique [0002] The process of blood coagulation, referred to as coagulation, is the process of blood changing from a flowing state to a gel state, and it is an important part of the hemostatic function. The coagulation process is a process in which a series of coagulation factors are successively enzymatically activated (commonly known as endogenous and extrinsic coagulation pathways in academia), which produces thrombin protein and promotes fibrinogen to form fibrous thrombus clots. Clinically commonly used test methods include activated partial thromboplastin time (APTT) and prothrombin time (PT) and some other parameters for the prevention and cure of diseases such as thrombosis or fibrinolysis. PT is one of the four routine blood coagulation items, main...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/12
CPCG01N27/12
Inventor 乔金R吴马里奥莫雷诺
Owner SHANGHAI UPPER BIO TECH PHARMA
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