A composition comprising an extract of combined herbs consisting of acanthopanax koreanum nakai and crinum asiaticum var. japonicum showing preventing activity of baldness and stimulating activity of hair growth

A technology of composition and extract, applied in drug combination, hair care, drug delivery, etc., can solve the problem of unreported or disclosed hair growth activity

Inactive Publication Date: 2016-05-11
SAM CHUN DANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, there is nothing reported or disclosed in any of the documents cited above regarding the hair growth activity of an extract of a combined herbal medicine consisting of eleuthero sativa and manjusri, the disclosures of which are incorporated herein by reference

Method used

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  • A composition comprising an extract of combined herbs consisting of acanthopanax koreanum nakai and crinum asiaticum var. japonicum showing preventing activity of baldness and stimulating activity of hair growth
  • A composition comprising an extract of combined herbs consisting of acanthopanax koreanum nakai and crinum asiaticum var. japonicum showing preventing activity of baldness and stimulating activity of hair growth
  • A composition comprising an extract of combined herbs consisting of acanthopanax koreanum nakai and crinum asiaticum var. japonicum showing preventing activity of baldness and stimulating activity of hair growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] Example 1: Combination of dry extracts of various herbs

[0104] 1-1.ACE1 combination

[0105] The extract of Acanthopanax koreanum japonicus prepared in the comparative example and the extract of Manjushri sibiricum prepared in the comparative example were mixed at a ratio of 1:1 (w / w) (hereinafter referred to as "ACE1"). In the following experimental examples, this powder was used as a test sample.

[0106] 1-2.ACE2 combination

[0107] The extract of Acanthopanax koreanum japonicus prepared in the comparative example and the extract of Magnolia sibiricum were mixed in a ratio of 2:1 (w / w) (hereinafter referred to as "ACE2"). In the following experimental examples, this powder was used as a test sample.

[0108] 1-3.ACE3 combination

[0109] The extract of Acanthopanax koreanum japonicus prepared in the comparative example and the extract of Magnolia sibiricum were mixed in a ratio of 1:2 (w / w) (hereinafter referred to as "ACE3"). In the following experimental examples, this ...

Embodiment 2

[0114] Example 2: Combination of herbal extracts

[0115] 2-1.ACC1 combination

[0116] The Cheonan and Cheju-do were washed with tap water, dried, cut, and mixed at a ratio of 1:1 (w / w) to obtain 300 g of a dry mixture. This mixture was added to 8 volumes of 50% (v / v) ethanol. The solution was refluxed and extracted at higher than 90°C for 2 hours, and the resulting residue was filtered with filter paper (Whatman Co.). The filtrate was concentrated with a rotary evaporator (Heidolph, Laboota4001) and dried with a freeze dryer (FDU-210, EYELA) to obtain an extract of the combined herbal medicine (hereinafter referred to as "ACC1"). In the following experimental examples, this powder was used as a test sample.

[0117] 2-2. ACC2 combination

[0118] Acanthopanax koreanensis and Manjushri orchid were mixed at a ratio of 2:1 (w / w) to obtain 300 g of a dry mixture. According to the similar method disclosed in Example 2-1, the mixture was extracted, and the filtrate was concentrated an...

experiment Embodiment 1

[0121] Experimental Example 1: Promoting hair growth

[0122] In order to confirm the preventive activity of the extract of the present invention on alopecia and the effect of stimulating hair growth activity, according to the method disclosed in the literature (HeeKyoungKang et al., Eur. J. Dermatol., 20(1), pages 42-48, 2010) Implement the following method.

[0123] 1-1. Preparation

[0124] Make 5-week-old mice (C57BL / 6, 15g-18g, at the beginning of mid-hair growth, CentralLabs.AnimalInc.Seoul, South Korea) accustomed to a breeding environment for 1 week, and intramuscular injection of anesthetic (2.5mg / mouse) , Ketamine, Xylazine, Bayer Korea Inc.) anesthesia. Use a shaving knife to remove the back hair of the anesthetized mice, and divide the mice into three groups, namely, (1) Negative control group: a treatment group using only excipients; (2) Comparative test group: in a dose-dependent manner Treatment group using the extract prepared in the comparative example dissolved i...

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Abstract

The present invention relates to a composition comprising an extract of combined herbs consisting of Acanthopanax koreanum Nakai and Crinum asiaticum var. japonicum showing preventing activity of baldness disorder and stimulating activity of hair growth. The inventive combined extract showed potent hair-growth promoting activity and synergistic effect than each herb, i.e. the sole treatment of Acanthopanax koreanum Nakai or Crinum asiaticum var. japonicum, through the animal model experiments such as the growth rate test using by C57BL / 6 mouse, to confirm the effect the inventive combined extract, i.e. combined treatment of Acanthopanax koreanum Nakai and Crinum asiaticum var. japonicum. Therefore the inventive extract can be useful in treating or preventing a baldness disorder.

Description

Technical field [0001] The present invention relates to a composition containing an extract of a combined herbal medicine composed of Acanthopanaxkoreanum Nakai and Crinumasiaticum var.japonicum, which exhibits hair loss preventive activity and hair growth stimulating activity. Background technique [0002] Hair follicle is a very complex organ, composed of inner hair root sheath (IRS), outer hair root sheath (ORS), hair shaft, hair mother cell (Paus et al., J. Invest. Dermatol., 113, pages 523-532, 1999) and Dermal papilla cells are composed of dermal papilla cells that play an important role in hair growth among various cells that form hair follicles (Ferraris et al., Exp. CellRes., 10, pages 37-46, 1997). [0003] Hair follicles develop through the interaction between mesenchymal cells and epithelial cells during embryonic development. The growth of normal hair consists of three repeated stages, namely, early hair growth, middle hair growth and end hair growth (Paus et al., N. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254A61K36/88A61K8/97A61P17/14
CPCA61K36/254A61K36/88A61K2800/5922A61Q7/00A61K8/9789A61K8/9794A61P17/14A61K2300/00A61K9/00A61K36/896A61K2236/33A61K2800/805A61Q5/00A61K2800/80
Inventor 林光津具敎哲郑善花李泰熙权才赫任善嬉李在镐
Owner SAM CHUN DANG PHARM
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