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Xanthone compositions, and preparation method, compositions and application thereof

A technology of compounds and compositions, applied in the field of natural compounds, can solve the problems of insensitivity, poor selectivity, and low efficiency

Active Publication Date: 2016-05-04
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The outstanding problems of the current clinical application of anti-tumor drugs are low effective rate, poor selectivity (high toxicity) and insensitivity to drug-resistant tumors
In addition, recurrence and metastasis are also difficulties in tumor treatment.

Method used

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  • Xanthone compositions, and preparation method, compositions and application thereof
  • Xanthone compositions, and preparation method, compositions and application thereof
  • Xanthone compositions, and preparation method, compositions and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1 Extracting and identifying OliganthinI, OliganthoneB and OliganthinH from the leaves of Bamboo chinensis

[0066] 1.1 Experimental materials

[0067] Shanhuashan bamboo was collected from Hainan Province in September 2013, and the plant was identified by Dr. Zhang Rongjing of South China Agricultural University. The plant samples were kept in the Innovative Chinese Medicine Laboratory of Shanghai University of Traditional Chinese Medicine.

[0068] 1.2 Test method

[0069] At room temperature, take the leaf powder (2.4 kg) of Shanhuashan Bamboo, extract it by percolation with petroleum ether until the percolation liquid is basically colorless, and evaporate the percolation liquid under reduced pressure to obtain 30 grams of dark green extract (A); Use 90% ethanol for percolation extraction until the percolation liquid is basically colorless, then evaporate the percolation liquid under reduced pressure to obtain 460 g of dark green extract (B).

[0070] Diss...

Embodiment 2

[0090] Embodiment 2 OliganthinI, OliganthinH, OliganthoneB inhibit human tumor cell proliferation

[0091] 2.1 Experimental materials

[0092] Human prostate cancer cell PC-3, human liver cancer cell HepG2, purchased from ATCC Company of the United States, human non-small cell lung cancer cell A549, human liver normal cell H17702, donated by Professor Lin Ge of the Chinese University of Hong Kong, human colon cancer cell HT-29, Presented by Professor Xu Naihan of Tsinghua University.

[0093] RPMI1640 was purchased from Hyclone Company of the United States, DMEM was purchased from Gibco Company of the United States, fetal bovine serum was purchased from PAN Company of Germany, penicillin and streptomycin were purchased from Hangzhou Gino Company, and Taxol was purchased from sigma Company of Germany.

[0094] 2.2 Experimental method

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Abstract

The invention relates to the field of natural compounds, especially to two novel compounds extracted from the bark of Garcinia oligantha and having a structural formula as described in the specification, or a pharmaceutically acceptable salt, hydrate or prodrug thereof, and a preparation method, a pharmaceutical composition and application thereof. In the formula, R is a methyl group or -CH2CH2CH=C(CH3)2. The compound can be used for preparation of drugs used for preventing and treating a plurality of tumors like prostatic cancers, liver cancers, lung cancers and colorectal cancers.

Description

technical field [0001] The invention relates to the field of natural compounds, in particular to a xanthone compound and its preparation method, pharmaceutical composition and application. Background technique [0002] Malignant tumors are currently the main diseases that threaten human health and life. Cancer is the second leading cause of death after cardiovascular disease in most developed countries. Tumor is also a major disease that seriously endangers the health of our people. Our country's tumor research has also been valued by the government. Tumor control has become one of the key points of our health strategy. [0003] Tumor treatments include surgery, radiation and chemotherapy. The outstanding problems of the current clinical application of anti-tumor drugs are low effective rate, poor selectivity (high toxicity) and insensitivity to drug-resistant tumors. In addition, recurrence and metastasis are also difficulties in tumor treatment. Therefore, it is a majo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/04C07D493/20A61K31/352A61P35/00
CPCC07D493/04C07D493/20
Inventor 徐宏喜唐跃勋付文卫吴蓉谭红胜
Owner SHANGHAI UNIV OF T C M
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