Preparation method of cocoyl glutamate acid

Abstract

The invention discloses a preparation method of cocoyl glutamate acid. The preparation method comprises that phosgene as a raw material is fed into cocinic acid as a raw material in a micro-melting state at a temperature of 70-120 DEG C, the mixture undergoes a reaction in the presence of an organic amine catalyst for 5-30h, wherein a mole ratio of cocinic acid, phosgene to the catalyst of 1: 1.05-3.5: 0.05-0.2, the reaction product is subjected to reduced pressure vacuum distillation to form cocoyl chloride, at the room temperature, sodium glutamate is dissolved in a mixed solution of alcohol and water, wherein a mass ratio of the alcohol to water is 1: 1.0-10.0, cocoyl chloride and sodium hydroxide aqueous solutions are dropwisely added into the system in 0.5-6h under control of the system temperature in a range of 0-50 DEG C along with stirring, wherein a mole ratio of sodium amino acid salt to cocoyl chloride is 1: 1.0-1.6 and the system pH is kept in a range of 6-15 through a sodium hydroxide dropwise addition rate and use amount, the system is stirred for 0.5-6h, the solvent is subjected to reduced pressure removal at a temperature of 0-100 DEG C for 0.5-6h, the system is cooled, hydrochloric acid is slowly and dropwisely added into the system at a temperature of 0-50 DEG C along with stirring until crystals are precipitated, wherein the pH of the system is kept in a range of 0-10 through a hydrochloric acid dropwise addition amount, and the crystals are subjected to suction filtration and dried so that obtain the cocoyl glutamate acid is obtained. The preparation method has a simple preparation route, can be operated simply, is safe, has a high yield and can be easily industrialized.

Description

technical field [0001] The invention relates to a preparation method of cocoyl glutamic acid. Background technique [0002] In recent years, amino acid series surfactants have attracted people's attention because of their safety, biodegradability and excellent surface activity. Cocoyl glutamic acid is made of highly safe materials, which is extremely gentle on the skin and will not cause allergies and phototoxicity; it has proper foam, strong washing power, and excellent adaptability to hard water; it can be quickly absorbed by organisms Decomposition; because it contains fatty acids, it can make the solution and micellar form obtain the required viscosity. Because of the above characteristics, it is widely used in transparent system or (pearl) facial cleanser, shampoo, shower gel, soap, detergent, shaving cream, toothpaste and industrial products. It can also be used in silk dyeing and finishing, antirust additives, Metal processing, mineral flotation and oil extraction a...

AI Technical Summary

Problems solved by technology

[0003] There is almost no synthesis of cocoyl glutamic acid. Progress in Fine and Specialty Chemicals Technology 2003 (23) reported the synthesis method of N-lauroyl glutamic acid. The solvent is acetone, which is more toxic. Due to the characteristics of active products, residual acetone will cause the product to turn yellow easily. At the same time, the reaction time of this method is long, exceeding 18 hours, and post-treatment purification requires two recrystallizations. The technology is cumbersome and lengthy, difficult to operate, time-consuming and labor-intensive, and seriously violates environmental protection. , security purpose