Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Material of support for treating femoral head necrosis and preparation method thereof

A femoral head necrosis and scaffold material technology, which is applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of osteoarthritis joint function, femoral head collapse, damage and other problems, and achieves good biocompatibility, no cytotoxic effect

Inactive Publication Date: 2016-05-04
SHANDONG ACAD OF CHINESE MEDICINE
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Avascular necrosis of the femoral head, especially non-traumatic avascular necrosis of the femoral head, occurs frequently in young and middle-aged people. Although the causes are different, they have similar pathological processes and results. Femoral head collapse, osteoarthritis, and impaired joint function occur, bringing heavy burdens to the family and society

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Material of support for treating femoral head necrosis and preparation method thereof
  • Material of support for treating femoral head necrosis and preparation method thereof
  • Material of support for treating femoral head necrosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation method of scaffold material for treating femoral head necrosis:

[0045] ① Preparation of Antler Gum

[0046] Crush the deer antler slices and place them in a round-bottomed flask, add 4-5 times (volume) of distilled water, and boil in water; take the juice every 3 hours, add water and cook until the deer antlers are soft and can be crushed by hand; The gum juice was combined, filtered to remove the residue, and concentrated to 1.2g / ml under reduced pressure with a vacuum concentrator at 50°C; cooled to room temperature to obtain the deerhorn gum solution, sterilized by radiation, and stored at 4°C.

[0047] ② Preparation of deproteinized bone

[0048] Take the cancellous bone at the lower end of the pig femur, soak it in normal saline for 24 hours, wash it with distilled water after taking it out, and put it in a closable container with 30% (v / v) H 2 O 2 Place the solution in a glass bottle in a constant temperature water bath at 37°C for 48 hours, and replace the ...

Embodiment 2

[0054] Preparation method of scaffold material for treating femoral head necrosis:

[0055] ① Preparation of Antler Gum

[0056] Crush the deer antler pieces and place them in a round-bottomed flask, add 4–5 times (volume) of distilled water, and boil; take the juice every 3 hours, add water and cook until the deer antlers are soft and soft, and can be crushed by hand; The gum juice is filtered to remove the residue, and concentrated to 1.0g / ml under reduced pressure with a vacuum concentrator at 50°C; the deerhorn gum solution is obtained after cooling to room temperature, sterilized by irradiation, and stored at 4°C.

[0057] ② Preparation of deproteinized bone

[0058] Take the cancellous bone at the lower end of the pig femur, soak it in normal saline for 24 hours, wash it with distilled water after taking it out, and put it in a closable container with 30% (v / v) H 2 O 2 Place the solution in a glass bottle in a constant temperature water bath at 37°C for 48 hours, and replace the...

Embodiment 3

[0064] Preparation method of scaffold material for treating femoral head necrosis:

[0065] ① Preparation of Antler Gum

[0066] Crush the deer antler pieces and place them in a round-bottomed flask, add 4–5 times (volume) of distilled water, and boil; take the juice every 3 hours, add water and cook until the deer antlers are soft and soft, and can be crushed by hand; The glue juice is filtered to remove the residue, and concentrated to 1.33g / ml under reduced pressure with a vacuum concentrator at 50°C; the deerhorn gum solution is obtained after cooling to room temperature, sterilized by irradiation, and stored at 4°C.

[0067] ② Preparation of deproteinized bone

[0068] Take the cancellous bone at the lower end of the pig femur, soak it in normal saline for 24 hours, wash it with distilled water after taking it out, and put it in a closable container with 30% (v / v) H 2 O 2 Place the solution in a glass bottle in a constant temperature water bath at 37°C for 48 hours, and replace t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Concentrationaaaaaaaaaa
Login to View More

Abstract

The invention relates to a material of a support for treating femoral head necrosis and a preparation method thereof. The material is prepared through the steps of mixing deerhorn glue-deproteinized bone powder with polycaprolactone according to the mass ratio of 1 to 4-5 and pouring the obtained mixture into an FDM three-dimensional printing ink box for printing. The deerhorn glue-deproteinized bone powder is prepared through the steps that deproteinized bones are put into a deerhorn glue solution, mixing, crosslinking and freeze-drying are conducted, and then superfine grinding is conducted on the obtained product, wherein the mass ratio of deerhorn glue to the deproteinized bones is 1 to 8.5-10. The support can enhance supporting to prevent femoral heads from collapse, sufficient structural support is provided to joint cartilages, and meanwhile sclerotin healing process is facilitated to accelerate creeping substitution of sclerotin.

Description

Technical field [0001] The invention relates to a scaffold material for treating femoral head necrosis, in particular to a cell scaffold material for treating ischemic femoral head necrosis and a preparation method thereof. Background technique [0002] Avascular Necrosis of the Femoral Head (ANFH) is a pathological process caused by the death of bone cells, bone marrow hematopoietic cells, and fat cells of the femoral head due to various reasons. It is a chronic progressive disabling disease. Without treatment, more than 70% of patients will have to undergo prosthesis replacement 3-4 years after diagnosis, and many patients have to face multiple joint replacements throughout their lives. Both mentally and economically, it is a heavy burden. The current joint replacement surgery and medical treatment have certain limitations. How to preserve the autologous femoral head, prevent it from collapsing, activate the cells in the necrotic site, and achieve the "regeneration" of the bo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/36A61L27/18A61L27/50
CPCA61L27/18A61L27/3608A61L27/365A61L27/50A61L2430/02C08L33/06
Inventor 王平高志惠张丽美孙铁锋师彬张猛李晓沫
Owner SHANDONG ACAD OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com