Ampicillin sodium and sulbactam sodium pharmaceutical composition

A technology of ampicillin sodium sulbactam sodium and ampicillin sodium, applied in the field of pharmaceutical compositions of ampicillin sodium sulbactam sodium, can solve the problems of drug safety impact, unfavorable safe drug use, easy introduction of impurities, etc., and achieve high The stability of solution clarity, self-stability, and the effect of improving safety

Active Publication Date: 2016-04-27
SICHUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, ampicillin sodium and sulbactam sodium are unstable during production and storage, and impurities are easily introduced, such as residual solvents in the production process, degradation of other polymers during storage, etc. These impurities can cause allergies when used clinically. Adverse reactions, which have a serious impact on drug safety, are not conducive to safe drug use in clinical practice

Method used

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  • Ampicillin sodium and sulbactam sodium pharmaceutical composition
  • Ampicillin sodium and sulbactam sodium pharmaceutical composition
  • Ampicillin sodium and sulbactam sodium pharmaceutical composition

Examples

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Embodiment 1

[0034] A pharmaceutical composition of ampicillin sodium sulbactam sodium, which is formed by mixing powder of sulbactam sodium and ampicillin sodium whose specific rotation is +264°, wherein the mass ratio of ampicillin sodium and sulbactam sodium is 2 :1.

Embodiment 2

[0036] A pharmaceutical composition of ampicillin sodium sulbactam sodium, which is formed by mixing powder of sulbactam sodium and ampicillin sodium whose specific rotation is +269°, wherein the mass ratio of ampicillin sodium and sulbactam sodium is 2 :1.

Embodiment 3

[0038] A pharmaceutical composition of ampicillin sodium sulbactam sodium, which is formed by mixing powder of sulbactam sodium and ampicillin sodium whose specific rotation is +267°, wherein the mass ratio of ampicillin sodium and sulbactam sodium is 2 :1.

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PUM

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Abstract

The present invention discloses an ampicillin sodium and sulbactam sodium pharmaceutical composition comprising sulbactam sodium and ampicillin sodium with the specific optical rotation of + 264 degrees to + 269 degrees, and the mass ratio of ampicillin sodium to sulbactam sodium is 2: 1. The ampicillin sodium and sulbactam sodium pharmaceutical composition is prepared from the sulbactam sodium and the ampicillin sodium with the particular specific optical rotation, the drug stability is improved, and drug safety is improved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition of ampicillin sodium sulbactam sodium. Background technique [0002] Ampicillin Sodium Sulbactam Sodium is a medicine for injection. The aliases are sultacillin, Youlixin, Shuminxin, Youlixin, Shutaxicillin, Ampicillin-Sulbactam. Its antibacterial mechanism is the same as that of penicillin G, which plays an antibacterial effect by binding to the main penicillin-binding proteins (PBPs) of bacteria and interfering with the synthesis of bacterial cell walls. Its role is characterized by a broad spectrum, not resistant to penicillinase. It is suitable for the treatment of sensitive bacteria, including respiratory tract infections, liver and gallbladder system infections, urinary system infections, and skin and soft tissue infections caused by β-lactamase-producing strains. Treatment of mixed infections of aerobic and anaerobic bacteria, especially abdominal in...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61K9/14A61K9/20A61K9/48A61P31/04C07D499/68C07D499/86C07D499/16
CPCA61K31/43C07D499/16C07D499/68C07D499/86
Inventor 李家成李穿江苏慧琴
Owner SICHUAN PHARMA
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