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Method for extracting and separating nervonic acid

A separation method and technology of nervonic acid, applied in the separation/purification of carboxylic acid compounds, organic chemistry, etc., can solve the problems of low nervonic acid content, long cycle, complicated process, etc., and achieve high yield, low production cost and excellent process simple effect

Active Publication Date: 2016-04-20
江西青春康源制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a method for extracting and separating nervonic acid, which mainly solves the problems of low content of nervonic acid extraction, complex process and long cycle in the existing method

Method used

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  • Method for extracting and separating nervonic acid
  • Method for extracting and separating nervonic acid
  • Method for extracting and separating nervonic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1: a kind of nervonic acid extraction and separation method comprises the following steps:

[0047] (1) extraction

[0048] (1.1) Get 100kg of maple ingot whose content of nervonic acid is 1% and pulverize;

[0049] (1.2) cross 10 mesh sieves through the raw material processed through step (1.1), then mix thoroughly with quicklime of 0.05 times raw material quality;

[0050] (1.3) extracting the raw material obtained through step (1.2) with n-hexane of 5 times the weight of the raw material, the extraction temperature is 45° C., and extracting 3 times, each time for 2 hours, to obtain the extract;

[0051] (2) concentrated

[0052] The extracts were combined and concentrated under reduced pressure until there was no n-hexane to obtain a concentrated solution;

[0053] (3) Acid adjustment

[0054] Add glacial acetic acid to the concentrate to make the pH of the concentrate=8;

[0055] (4) Extraction

[0056] (4.1) extracting the concentrated solution obt...

Embodiment 2

[0074] Embodiment 2: a kind of nervonic acid extraction and separation method comprises the following steps:

[0075] (1) extraction

[0076] (1.1) Get 100 kg of Vitex twig raw material with nervonic acid content as 2% and pulverize;

[0077] (1.2) cross 10 mesh sieves through the raw material processed through step (1.1), then mix thoroughly with quicklime of 0.07 times raw material quality;

[0078] (1.3) Extract the raw material obtained through the treatment in step (1.2) with n-hexane that is 8 times the weight of the raw material, the extraction temperature is 45° C., and extract 3 times, each time for 2 hours, to obtain the extract;

[0079] (2) concentrated

[0080] The extracts were combined and concentrated under reduced pressure until there was no n-hexane to obtain a concentrated solution;

[0081] (3) Acid adjustment

[0082] Add glacial acetic acid to the concentrate to make the pH of the concentrate=8;

[0083] (4) Extraction

[0084] (4.1) extracting the ...

Embodiment 3

[0102] Embodiment 3: a kind of nervonic acid extraction and separation method comprises the following steps:

[0103] (1) extraction

[0104] (1.1) getting nervonic acid content is that 100kg of garlic fruit raw material of 5% is pulverized;

[0105] (1.2) cross 10 mesh sieves through the raw material processed through step (1.1), then mix thoroughly with unslaked lime of 0.1 times raw material quality;

[0106] (1.3) extracting the raw material obtained through the treatment in step (1.2) with n-hexane 10 times the weight of the raw material, the extraction temperature is 45° C., and extracting 3 times, each time for 2 hours, to obtain the extract;

[0107] (2) concentrated

[0108] The extracts were combined and concentrated under reduced pressure until there was no n-hexane to obtain a concentrated solution;

[0109] (3) Acid adjustment

[0110] Add glacial acetic acid to the concentrate to make the pH of the concentrate=8;

[0111] (4) Extraction

[0112] (4.1) extra...

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Abstract

The invention provides a method for extracting and separating nervonic acid, mainly aiming at solving the problems that the nervonic acid extracted and separated by the existing method is low in purity, and the existing method for extracting and separating the nervonic acid is complicated in process, not easy in realization of industrial production and long in period. The method for extracting and separating the nervonic acid comprises the following steps: (1) extracting; (2) concentrating; (3) carrying out acid regulation; (4) extracting; (5) carrying out ordinary pressure column chromatography. The method is clear and definite in goal; the nervonic acid with content of more than 95% can be stably obtained by the simple and feasible method; furthermore, multiple raw materials containing the nervonic acid can be used for extracting, so that the raw materials are fully utilized, and reasonable development is realized.

Description

technical field [0001] The invention relates to an extraction and separation method of nervonic acid, in particular to an extraction and separation method of nervonic acid with high yield and low production cost. Background technique [0002] The Chinese patent of CN1398844 discloses a production process of extracting and purifying nervonic acid, which is to first obtain the crude nervonic acid in the form of glyceride from crushed oily fruits by supercritical extraction of carbon dioxide, and then extract the crude nervonic acid in the form of glyceride Acid conversion of crude nervonic acid in free form, and then using an emulsifier to separate and obtain high-purity nervonic acid through emulsification separation, the extraction of nervonic acid according to this method is expensive, and the process method is vague and low in technical content. [0003] The Chinese patent of CN101092344B discloses a method for extracting nervonic acid from maple ingot oil by molecular dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C57/03C07C51/42
CPCC07C51/42C07C57/03
Inventor 周建兴黄样华宋细忠徐长毫晏小春解德桂
Owner 江西青春康源制药有限公司
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