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Preparation method of slow-released lomefloxacin injection

A slow-release lomefloxacin and lomefloxacin technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of increasing animal emergencies and increasing breeding costs. To achieve the effect of prolonging the release time

Inactive Publication Date: 2016-04-20
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the defects of the prior art, and provides a preparation method capable of prolonging the half-life of lomefloxacin injection, so as to solve the need for repeated medications in the treatment process of long-duration animal diseases in the prior art, increasing the emergency and The problem of increasing the cost of farming

Method used

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  • Preparation method of slow-released lomefloxacin injection

Examples

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Effect test

Embodiment 1

[0027] Preparation of 5% lomefloxacin n-hexanoate injection

[0028] Take 5g of lomefloxacin (pure) and 40g of tetrahydrofurfuryl alcohol, stir and dissolve until clear, add 1g of n-hexanoic acid and slowly stir for complexation for 1 hour, add 5g of poloxamer and continue stirring until clear, and dilute the volume of tetrahydrofurfuryl alcohol to 100ml. Filter through a 0.45 μm organic membrane to obtain 5% lomefloxacin injection.

Embodiment 2

[0030] Preparation of 10% Lomefloxacin Laurate Injection

[0031] Take 10g of lomefloxacin (Zhechun) and 40g of propylene glycol, stir and dissolve until clear, add 2g of lauric acid and slowly stir for complexation for 2h, add 10g of glycerin fatty acid ester and continue stirring until clear, dilute the volume of propylene glycol to 100ml, and use 0.45μm organic Membrane filtration to obtain 10% lomefloxacin laurate injection.

Embodiment 3

[0033] Preparation of 15% Lomefloxacin Palmitate Injection

[0034] Take 15g of lomefloxacin (pure) and 40g of dimethyl sulfoxide, stir and dissolve until clear, add 3g of palmitic acid and slowly stir for complexation for 3 hours, then add 20g of fatty acid glycerides and continue stirring until clear, and dilute the volume of dimethyl sulfoxide to 100ml , and filtered through a 0.45 μm organic membrane to obtain 15% lomefloxacin palmitate injection.

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Abstract

The invention provides a preparation method of a slow-released lomefloxacin injection, and belongs to a slow-released injection for animals. The lomefloxacin injection is prepared from, by weight, 5%-20% of lomefloxacin, 1%-4% of fatty acid, 5%-35% of stabilizer and the balance organic solvent. The preparation method comprises the steps that lomefloxacin and the organic solvent are taken and stirred for dissolution, the fatty acid is added to conduct a complexation reaction with a dissolved product, the stabilizer is added, after sufficient dissolution is achieved, the organic solvent is added for the scale volume, and the slow-released lomefloxacin injection is obtained after membrane filtration is conducted. According to the preparation method of the slow-released lomefloxacin injection, lomefloxacin or a salt hydrate thereof is reacted with the fatty acid to form a new compound, the release time of lomefloxacin can be prolonged, the effective blood drug concentration of a drug in an animal body can be maintained for a long time, and therefore the purposes of decreasing the frequency of drug delivery and reducing drug stress are achieved.

Description

technical field [0001] The invention relates to a preparation method of veterinary injection, in particular to a preparation method of sustained-release lomefloxacin injection. Background technique [0002] Lomefloxacin belongs to fluoroquinolones, and its antibacterial activity in vitro is similar to that of norfloxacin, slightly worse than that of ciprofloxacin, but its antibacterial activity in vivo, including the effects on E. significantly better than norfloxacin. This product is a third-generation quinolone antibacterial drug with a broad antibacterial spectrum. Its antibacterial activity against Gram-positive bacteria is the same as that of norfloxacin, and stronger than that of enoxacin; it has the same effect on Gram-negative bacteria as enoxacin. , weaker than norfloxacin. It is clinically used for respiratory and urinary tract infections caused by sensitive bacteria. The product is invalid for Streptococcus, Streptococcus pneumoniae, Pseudomonas cepacia, Mycopl...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/496A61K47/48A61P31/04A61K47/54
CPCA61K9/0019A61K9/08A61K31/496
Inventor 董萌萌付旭彬杨保收梁武
Owner TIANJIN RINGPU BIO TECH
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