Voriconazole compound aqueous emulsion preparation for treating fungal skin diseases in pets

Abstract

The invention discloses a voriconazole compound aqueous emulsion preparation for treating fungal skin diseases in pets, and relates to the technical field of a medicine. The preparation mainly consists of the following materials according to a formula: voriconazole, tinidazole and dexamethasone, and further consists of the following adjuvant materials: tween-80, propanediol and pure water, wherein the mass percentage of the formula materials is at (5-15g) to (3-8g) to (0.5-2g) to (25-35ml) to (25-35ml) to (80-120ml) of the voriconazole to the tinidazole to the dexamethasone to the tween-80 to the propanediol to the pure water; and a preparation technology of the formula comprises the following processes: (1) heating the tween-80 (30ml) and the propanediol (30ml) in a container; (2) while heating, pouring the voriconazole (10g), the tinidazole (5g) and the dexamethasone (1g); (3) heating until the materials are dissolved, and stopping warming up; and (4) adding the pure water to 100ml, and uniformly stirring, so that the preparation is obtained. The preparation disclosed by the invention has the beneficial effects that the preparation can solve difficulties in skin repair treatment of fungal pyoderma in the pets; the preparation is broad in economic benefit and prospect and is considerable in benefit; and the preparation has the advantages of simple materials, reasonable design, low preparation cost and the like.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a voriconazole compound water-emulsion preparation for pet fungal skin diseases. Background technique [0002] At present, there are only voriconazole tablets for human use in China, and there are voriconazole freeze-dried powder injections abroad, but there are no other dosage forms, and there is no compound voriconazole water emulsion. Voriconazole Tablets, Indications This product is a broad-spectrum triazole antifungal drug, and its indications are as follows: treatment of invasive aspergillosis. Treatment of severe invasive infections caused by fluconazole-resistant Candida species (including Candida krusei). Treatment of serious infections caused by Actinomycetes and Fusarium species. This product should be used primarily for the treatment of progressive, potentially life-threatening infections in immunocompromised patients. [0003] The prior art cannot satisfy pet me...

AI Technical Summary

Problems solved by technology

[0003] Existing technology can’t satisfy pet medicine: 1. It is inconvenient for pets to take tablets, 2. There is no voriconazole preparation in the field of pets