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Medicine composition, preparation method thereof, preparation and application

A composition and drug technology, applied in the field of pharmaceutical composition and its preparation, can solve the problems of large side effects, long-term medication, etc., and achieve the effects of small side effects, high bioavailability, and fast dissolution

Inactive Publication Date: 2016-03-23
普洱淞茂滇草六味制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned medicines all have considerable side effects and need to be taken for a long time. Therefore, it is very necessary to develop a kind of blood-fat and blood-pressure-lowering medicine with little side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0019] The preparation method of the pharmaceutical composition of the present invention includes pretreatment, coarse pulverization, ultrafine pulverization and mixing processes, specifically including:

[0020] A. Pretreatment: Eliminate the sundries in each raw material, select, wash, dry in the sun, and dry until the moisture content is ≤3% for later use;

[0021] B. Coarse crushing: the raw materials Panax notoginseng, Polygonum multiflorum produced in Yunnan, Salvia miltiorrhiza and Hawthorn are respectively pulverized with a coarse pulverizer, and passed through a 80-140 mesh sieve for subsequent use;

[0022] C, superfine pulverization: each raw material after coarse pulverization is superfine pulverized respectively to obtain the superfine powder of each raw material;

[0023] D. Mixing: According to the formula ratio, the ultrafine powder of each raw material is mixed evenly to obtain the target object.

[0024] The particle diameter of the ultrafine powder is 6-12 ...

Embodiment 1

[0030] ——The preparation method of described pharmaceutical composition

[0031] A. Pretreatment: Take 50kg of Panax notoginseng, 50kg of Salvia miltiorrhiza, and 50kg of hawthorn, and place them in a SUS304 stainless steel XSG-600 circulating water cleaning machine, use water spray and general water cleaning, and tumbling friction of the medicinal materials to remove the sediment of the medicinal materials, etc. The rotation speed of the cylinder is 12rpm, and then the sundries in the medicinal materials are removed, sorted, and then sliced. The sliced ​​Panax notoginseng is sterilized in an oven. The sterilization time is set to 5min, and the sterilization temperature is 75°C. The finished salvia miltiorrhiza was sterilized in an oven, the sterilization time was set to 10min, and the sterilization temperature was 70°C, and the sliced ​​hawthorn was sterilized in an oven, the sterilization time was set to 10min, and the sterilization temperature was 70°C , and then put Panax ...

Embodiment 2

[0037] Get the pharmaceutical composition prepared in Example 1 and pack into powder.

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Abstract

The invention discloses a medicine composition, a preparation method thereof, preparation and application. The medicine composition consists of radix notoginsengs, Yunnan fallopia multiflora, salvia miltiorrhiza and hawthorns, wherein the weight ratio is (0.5-1.5):( 0.5-1.5):(0.5-1.5):(0.5-1.5). The preparation method comprises the working procedures of preprocessing, coarse grinding, superfine grinding and mixing. The preparation is powder, tablets, granules, capsules, dripping pills or honey pills prepared by adding pharmaceutically acceptable auxiliary materials into the medicine composition. The medicine composition is applied to preparation of medicines for lowering blood pressure and blood fat. The medicine composition is prepared through mixing according to precisely set composition, achieves the effect of lowering blood pressure and blood fat according to physical and chemical properties of the raw medicines and compatibility of contained active ingredients and has the advantages of being high in bioavailability, fast in active ingredient dissolution, good in medicine absorption effect and small in side effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparation, and in particular relates to a pharmaceutical composition, a preparation method, preparation and application thereof. Background technique [0002] Hyperlipidemia refers to excessive blood lipid levels, which can directly cause some diseases that seriously endanger human health, such as atherosclerosis, coronary heart disease, pancreatitis, etc. Hyperlipidemia can be divided into two types: primary and secondary. Primary is congenital and hereditary, and is caused by abnormalities in receptors, enzymes, or apolipoproteins involved in lipoprotein transport and metabolism due to single or polygenic defects, or due to environmental factors (diet, nutrition, drugs) ) and by unknown mechanisms. Secondary mostly occurs in metabolic disorders (diabetes, hypertension, myxedema, hypothyroidism, obesity, liver and kidney disease, adrenal hyperfunction), or in combination ...

Claims

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Application Information

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IPC IPC(8): A61K36/734A61P9/12A61P3/06
CPCA61K36/734A61K36/258A61K36/537A61K36/704A61K2300/00
Inventor 刘宝
Owner 普洱淞茂滇草六味制药股份有限公司
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