Pharmaceutical composition containing moxifloxacin for resisting pulmonary fibrosis
A technology of pulmonary fibrosis and moxifloxacin, which is applied in the field of medicine, can solve the problems of cyclophosphamide with large side effects and inaccurate curative effect, and achieve the effects of low side effects, low side effects and adverse reaction rates, and low toxicity
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[0022] Example 1 Experimental study of moxifloxacin combined with curcumin against pulmonary fibrosis
[0023] 56 adult SD rats, half male and half male, weighing 200-250g. Randomly divided into: model control group, moxifloxacin treatment group, curcumin treatment group, moxifloxacin combined with curcumin treatment group; the 3 treatment groups were divided into 2 subgroups of 4d and 10d according to the course of treatment, each with 8 animals . A one-time intraperitoneal injection of 20% paraquat solution at a dose of 18 mg / kg was selected to prepare a SD rat paraquat poisoning pulmonary fibrosis model. 2h after exposure, the moxifloxacin group, curcumin group, and combination medication group were given moxifloxacin 40mg / kg, curcumin 160mg / kg, moxifloxacin 10mg / kg + curcumin 80mg / kg by gavage, repeated every 12h The administration was given once, divided into 2 courses of 4d and 10d; the model control group was given only equal volume of normal saline. On the 22nd day aft...
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