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Pharmaceutical composition for treating ichthyosis and preparation method of pharmaceutical composition

A composition and technology for ichthyosis, which are applied in directions such as drug combinations, pharmaceutical formulations, active ingredients of hydroxy compounds, etc., can solve problems such as inconvenience in taking, inaccurate curative effect, etc., and can prevent skin dryness, maintain skin oil-water balance, and have a simple preparation process. Effect

Active Publication Date: 2016-02-03
PEKING UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine calls ichthyosis "snake skin disease", "fish scale wind", etc., and believes that it is caused by congenital deficiency, acquired loss of nourishment, blood deficiency and wind dryness, and loss of nutrition and health. , commonly used in combination with oral administration and external application, most of which are decoctions and tinctures, which are inconvenient to take and have uncertain curative effects

Method used

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  • Pharmaceutical composition for treating ichthyosis and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating ichthyosis and preparation method of pharmaceutical composition
  • Pharmaceutical composition for treating ichthyosis and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] 1) Weigh the raw materials according to the following ratio (unit: × 10g)

[0054]

[0055] Wherein, vitamin E emulsifiable paste selects 10% vitamin E emulsifiable paste; Aromatic agent selects fragrance essential oil (rosemary essential oil); Water selects sterile deionized water;

[0056] 2) Heat the deionized water placed in the water bath and keep the temperature at 55°C, add N-acetylcysteine ​​and urea, stir to dissolve, and mix well;

[0057] 3) Then add glycerin, stir and mix well, then add sodium hydroxide, and stir evenly to obtain a premix;

[0058] In order to avoid adding sodium hydroxide to water to release a large amount of heat, it is necessary to slowly add sodium hydroxide to the water, and stir to dissolve during the addition process; adding sodium hydroxide promotes the fusion of N-acetylcysteine ​​and glycerin, and the emulsification is uniform.

[0059] 4) adding concentrated hydrochloric acid to the premix to adjust the pH of the premix to 4.7...

Embodiment 2

[0064] 1) Weigh the raw materials according to the following ratio (unit: × 10g)

[0065]

[0066] Wherein, vitamin E emulsifiable cream selects 10% vitamin E emulsifiable cream; Aromatic agent selects fragrance essential oil (rosemary essential oil); Water selects deionized water;

[0067] 2) After heating the water in the water bath and keeping the temperature at 50°C, add N-acetylcysteine ​​and urea, stir to dissolve, and mix well;

[0068] 3) Then add glycerin, stir and mix well, then add sodium hydroxide, and stir evenly to obtain a premix;

[0069] 4) adding concentrated hydrochloric acid to the premix to adjust the pH of the premix to 5.0 to obtain an aqueous phase mixture;

[0070] 5) Put vitamin E cream in a water bath, heat and keep the temperature at 50°C, stir and melt, add fragrance (rosemary essential oil), stir and mix evenly to obtain Ve-fragrance mixture;

[0071] 6) Take out the Ve-fragrance mixture from the water bath, add the water phase mixture, stir ...

Embodiment 3

[0074] 1) Weigh the raw materials according to the following ratio (unit: × 10g)

[0075]

[0076] Wherein, vitamin E emulsifiable paste selects 10% vitamin E emulsifiable paste; Fragrance agent selects fragrance essential oil (rose essential oil); Water selects deionized water;

[0077] 2) After heating the water in the water bath and keeping the temperature at 60°C, add N-acetylcysteine ​​and urea, stir to dissolve, and mix well;

[0078] 3) Then add glycerin, stir and mix well, then add sodium hydroxide, and stir evenly to obtain a premix;

[0079] 4) adding concentrated hydrochloric acid to the premix to adjust the pH of the premix to 4.5 to obtain an aqueous phase mixture;

[0080] 5) Put vitamin E cream in a water bath, heat and keep the temperature at 60°C, stir and melt, add fragrance, stir and mix evenly to obtain Ve-fragrance mixture;

[0081] 6) Take out the Ve-fragrance mixture from the water bath, add the water phase mixture, stir while adding, and mix evenly...

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PUM

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Abstract

The invention discloses a composition for treating ichthyosis and a preparation method of the composition. The composition is prepared from the following raw materials: N-acetylcysteine, urea, sodium hydroxide, a vitamin E emulsible paste, glycerol, an aromatic and water. The composition disclosed by the invention, in accordance with clinical symptoms of ichthyosis, is prepared from various medicinal components which are mutually matched, and active ingredients of the composition are mutually combined to take a synergetic effect so as to effectively regulate the pathological state of the ichthyosis and to achieve a significant effect on resisting skin keratinizing; and the composition disclosed by the invention has a significant curative effect on the ichthyosis, and the composition is rapid in action, convenient to use and free from toxic and side effects.

Description

technical field [0001] The invention relates to an external medicinal composition for treating skin diseases and a preparation method thereof, in particular to a medicinal composition for treating ichthyosis and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Ichthyosis is a group of epidermal dyskeratosis skin diseases caused by genetic defects, mainly manifested as dry, rough skin, accompanied by fish scales. The disease often occurs shortly after birth, and the main manifestations are dry and rough skin on the extensor sides of the limbs or the trunk, accompanied by diamond-shaped or polygonal scales. Aggravated by cold and dry seasons and relieved by warm and wet seasons. The multilineal genetic factors of this disease cause abnormal proliferation and differentiation of epidermal cells, resulting in increased cell proliferation and (or) decreased cell shedding. [0003] Lamellar ichthyosis (Lamellarichthyosis, LI) is a ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/355A61P17/00A61K31/198A61K31/17A61K31/047
Inventor 汪慧君林志淼杨勇
Owner PEKING UNIV FIRST HOSPITAL
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