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ALDOA autoantibody andapplications thereof in diagnosis of esophageal squamous cell carcinoma

An autoantibody and esophageal squamous cell technology, applied in the fields of biotechnology and medicine, can solve the problem of no sensitive and effective non-invasive diagnostic methods for esophageal squamous cell carcinoma

Inactive Publication Date: 2016-01-27
汕头大学医学院附属肿瘤医院 +2
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Problems solved by technology

[0006] Another object of the present invention is to provide the use of ALDOA autoantibodies as a diagnostic marker for esophageal squamous cell carcinoma, so as to solve the problem that there is currently no sensitive and effective non-invasive diagnostic method for esophageal squamous cell carcinoma

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  • ALDOA autoantibody andapplications thereof in diagnosis of esophageal squamous cell carcinoma
  • ALDOA autoantibody andapplications thereof in diagnosis of esophageal squamous cell carcinoma
  • ALDOA autoantibody andapplications thereof in diagnosis of esophageal squamous cell carcinoma

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Embodiment Construction

[0018] The present invention is described further in conjunction with embodiment and accompanying drawing.

[0019] 1. Serum collection from patients with esophageal squamous cell carcinoma and normal subjects

[0020] Serum samples from patients with esophageal squamous cell carcinoma and normal subjects were collected from the Cancer Hospital Affiliated to Shantou University School of Medicine. This study was approved by the Ethics Committee of the Cancer Hospital Affiliated to Shantou University School of Medicine. Blood samples at 1250 g Serum was collected by centrifugation for 5 minutes, and all samples were stored in a -80°C refrigerator. All patients were pathologically diagnosed as esophageal squamous cell carcinoma. The samples of normal subjects came from hospital medical staff, and the age and sex were matched with patients with esophageal squamous cell carcinoma. Using serum proteome research techniques (such as figure 1 shown), sera from 8 patients with esopha...

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Abstract

The invention belongs to the technical field of biotechnology and medical technology, and relates to a marker ALDOA autoantibody for distinguishing between esophageal squamous cell carcinoma patients and normal persons, and a detection method and applications thereof. In the invention, the serum proteome research technology is adopted to identify a new marker ALDOA autoantibody for esophageal squamous cell carcinoma. Purified ALDOA proteins are subjected to ELISA analysis for detecting expression level of the ALDOA autoantibody in serums of esophageal squamous cell carcinoma patients and normal persons, and the results indicate that the level of the ALDOA autoantibody in the serum of esophageal squamous cell carcinoma patients is obviously higher than that of the normal persons. The ALDOA autoantibody of the invention can serve as the marker of the esophageal squamous cell carcinoma and can be used in the diagnosis of the esophageal squamous cell carcinoma.

Description

technical field [0001] The invention belongs to the fields of biotechnology and medicine. More specifically, it relates to a marker ALDOA (aldolaseA, fructose-bisphosphate) autoantibody capable of distinguishing patients with esophageal squamous cell carcinoma from normal people, its detection method and application. Background technique [0002] Esophageal cancer is a common malignant tumor of the upper gastrointestinal tract. It ranks eighth in incidence and sixth in mortality among various cancers worldwide. Histopathological examination results showed that esophageal cancer mainly includes two histopathological types: esophageal squamous cell carcinoma and esophageal adenocarcinoma. More than 90% of esophageal cancer cases in my country are esophageal squamous cell carcinoma; esophageal adenocarcinoma mainly occurs in the United States and other western countries. At present, the overall 5-year survival rate of esophageal cancer is less than 15%. The serious situatio...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/574
Inventor 许镒洧彭裕辉许丽艳李恩民
Owner 汕头大学医学院附属肿瘤医院
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