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Application of pharmaceutical compositions in preparation of drugs for treating sterile pustular dermatosis

A composition and aseptic technology, applied in the field of medicine, can solve the problems of excessive urine output and easy recurrence of patients

Active Publication Date: 2016-01-27
施惠娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Drug therapy combined with local treatment: (1) Glucocorticoid: has a good therapeutic effect, but it is easy to relapse after stopping the drug
Glycyrrhizic acid is currently considered as a plant hormone, which has anti-inflammatory, anti-allergic, anti-viral, and liver-protecting effects. For the etiology and pathogenesis of aseptic pustular dermatosis, matrine and glycyrrhizic acid are both effective on aseptic There is a mechanism of drug treatment for pustular dermatosis, but the effective extract of Sophora flavescens or matrine has side effects such as diuresis and natriuresis in clinical practice, resulting in excessive urine output, diarrhea, etc.

Method used

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  • Application of pharmaceutical compositions in preparation of drugs for treating sterile pustular dermatosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Comparison of acute toxic effects of oxymatrine, glycyrrhizic acid and their compositions on mice

[0024] Kunming mice were randomly divided into a normal control group and a test drug group, with ten mice in each group, half male and half male. In addition to the normal control group, the test drug group was injected intraperitoneally (ip) with a large dose of oxymatrine, glycyrrhizin and the combination of the two components once, and the animals were observed continuously for 7 days, and the death time and number of animals were recorded.

[0025]The results showed that when the dose of oxymatrine was 950mg / kg, it had great toxicity, and 9 of the 10 mice died; when the dose of glycyrrhizin was 950mg / kg, 2 of the 10 mice died, while the oxidized Kushen minus: glycyrrhizin ratio 1:1 and combined dose of 950mg / kg and matrine: glycyrrhizin ratio of 2:1 and combined dosage of 950mg / kg, no animals died, oxidized matrine reduced: glycyrrhizin When the ratio of oxymatrin...

Embodiment 2

[0030] Observation on the curative effect of compound glycyrrhizin combined with oxymatrine in the treatment of palmoplantar pustulosis

[0031] 1 Materials and methods

[0032] 1.1 Clinical data The clinical diagnosis conforms to 40 patients with palmoplantar pustulosis, 20 males and 20 females, aged 20 to 50 years, who have not received treatment within one month, have no serious internal organ diseases such as liver and kidney dysfunction, and have no activities The medical history of tuberculosis, hypertension, diabetes and cataract was excluded, and pregnant and lactating women were excluded. The patients were randomly divided into four groups: oxymatrine treatment group (group A), compound glycyrrhizin treatment group (group B), oxymatrine combined with compound glycyrrhizin treatment group (group C), and control group (group D). group), ten cases in each group, half male and half male. There was no statistical difference among the four groups in terms of age, gender...

Embodiment 3

[0044] Observation on the curative effect of compound glycyrrhizin combined with oxymatrine in the treatment of subcorneal impetigo

[0045] 1 Materials and methods

[0046] 1 Materials and methods

[0047] 1.1 Clinical data The clinical diagnosis was consistent with subcorneal impetigo in 4 patients, 2 males and 2 females, aged 24-42 years.

[0048] 1.2 Treatment method Intravenous infusion of oxymatrine injection 0.6g 100ml / d and compound glycyrrhizin injection 120mg / d; both take 4 weeks as a course of treatment, and judge the curative effect after the course of treatment is over.

[0049] 1.3. Clinical recovery means that the skin lesions have disappeared by more than 90%; markedly effective means that the skin lesions have disappeared by 60% to 89%; progress means that the skin lesions have disappeared by 20% to 59%; ineffective means that the skin lesions have disappeared by less than 20%. The effective rate is calculated by clinical recovery plus marked effect.

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Abstract

The invention relates to kushenin (oxymatrine and matrine) and glycyrrhizic acid or their pharmaceutically acceptable forms or derivatives and a kit containing the compositions, also relates to matrine glycyrrhizate and kushenin glycyrrhizate, and discloses an application of the compositions in preparation of drugs for preventing and treating sterile pustular dermatosis (comprising impetigo herpetiformis, acrodermatitis continua, palmoplantar pustulosis, subcorneal lpustular dermatosis, and eosinophilic pustular folliculitis).

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the application of a pharmaceutical composition in the preparation of prevention and treatment of aseptic pustular dermatosis. The pharmaceutical composition contains matrine (oxymatrine, matrine, isomatrine) and glycyrrhizic acid or a pharmaceutically acceptable form of the two or derivatives of the two and the composition containing these The medicine box also includes glycyrrhizic acid matrine salt and glycyrrhizic acid matrine salt. Background technique [0002] Aseptic pustular dermatoses include impetigo herpetiformis, acrodermatitis continuum, palmoplantar impetigo, subcorneal impetigo, and eosinophilic pustular folliculitis. The pathological changes were all characterized by the infiltration of neutrophils in the epidermis and the formation of Kogoj's cavernous pustules. The etiology and pathogenesis of aseptic pustular dermatosis are still unclear. (1) Infection factors: related...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P17/00A61P29/00A61K31/4375
Inventor 施惠娟
Owner 施惠娟
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