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pan-elr + CXC Chemokine Antibody

A technology of antibodies and chemoattractant proteins, applied in the direction of antibodies, anti-cytokines/lymphokines/interferon immunoglobulins, anti-tumor drugs, etc. Disclosing issues such as antibodies

Active Publication Date: 2022-05-24
ELI LILLY & CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the publication does not demonstrate that the antibody binds tightly to GCP-2 (CXCL6) and does not mention binding to NAP-2 (CXCL7)
[0006] However, no antibodies capable of binding and neutralizing all 7 human ELR+ CXC chemokines have been published

Method used

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  • pan-elr <sup>+</sup> CXC Chemokine Antibody
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  • pan-elr <sup>+</sup> CXC Chemokine Antibody

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Embodiment

[0040] Expression and production of antibodies

[0041] Antibodies for use in the present invention can be expressed and purified as follows. NS0 cells were transfected with expression vectors comprising the DNA sequences of SEQ ID NO: 5 (encoding the heavy chain polypeptide of SEQ ID NO: 1) and SEQ ID NO: 6 (encoding the light chain polypeptide of SEQ ID NO: 3). The antibody obtained from this expression vector is "Antibody 1".

[0042]Additionally, NS0 cells were transfected with expression vectors comprising the DNA sequences of SEQ ID NO: 17 (encoding the heavy chain polypeptide of SEQ ID NO: 13) and SEQ ID NO: 18 (encoding the light chain polypeptide of SEQ ID NO: 15). The antibody obtained from this expression vector is "Antibody 2".

[0043] For Antibody 1 or Antibody 2, transfection pools were plated at low density to allow growth of nearly monoclonal stable expressing cells. Master wells were screened for antibody expression and then scaled up for production in se...

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Abstract

Provides Pan‑ELR that specifically binds 7 human ELR+CXC chemokines + CXC chemokine antibody. The antibodies of the invention are useful in the treatment of various inflammatory / autoimmune diseases, such as inflammatory bowel disease (IBD), psoriasis, and pustulosis palmoplantar; and cancers, such as renal or ovarian cancer.

Description

[0001] This application is a Chinese patent application 201480013248.X "Pan-ELR" on March 5, 2014 + CXC Chemokine Antibodies" divisional application. technical field [0002] The present invention relates to antibodies directed against ELR+ CXC chemokines and their use in the treatment of diseases whose pathogenesis is mediated by ELR+ CXC chemokines. Background technique [0003] ELR+ CXC chemokines (so called because members of this chemokine family all have an E-L-R amino acid motif next to their CXC motif) play important roles in a variety of pathogenesis, including neutrophil recruitment to inflammation and blood vessels Migration of generative sites. Neutrophils contribute to the pathogenesis of several acute and chronic inflammatory / autoimmune diseases, such as inflammatory bowel disease (IBD), psoriasis, and palmoplantar pustulosis. ELR+ CXC chemokines also play key roles in tumorigenesis and tumor metastasis. These chemokines are highly expressed in tumors. In ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K16/24A61K39/395A61P17/06A61P17/00
CPCC07K16/24A61K2039/505C07K2317/34C07K2317/76C07K2317/33C07K2317/92A61P1/00A61P17/00A61P17/06A61P35/00
Inventor C.B.贝德勒K.K.基克利B.A.斯特里夫勒D.R.维彻尔J.S.博伊尔斯
Owner ELI LILLY & CO
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