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Use of NONRATT021972 small interfering RNA in preparation of drug for treating myocardial ischemia injury and sympathetic nerve diseases

A technology of NONRATT021972, myocardial ischemia, applied in nervous system diseases, cardiovascular system diseases, drug combinations, etc., can solve the problem of unclear myocardial ischemia damage of small interfering ribonucleic acid, and achieve prevention and treatment of sympathetic nervous diseases, alleviation or relief The effect of myocardial ischemia injury

Active Publication Date: 2016-01-20
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether long non-coding RNA NONRATT021972 small interfering RNA can protect myocardial ischemic injury is not clear, whether it can act on cervical sympathetic ganglion nerve cells P2X 7 Receptors affect myocardial ischemia-induced sympathetic enhancement reflex to produce protective effects on myocardial, cardiovascular, and cardiac sympathetic nerve injuries. There is no literature report yet

Method used

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  • Use of NONRATT021972 small interfering RNA in preparation of drug for treating myocardial ischemia injury and sympathetic nerve diseases
  • Use of NONRATT021972 small interfering RNA in preparation of drug for treating myocardial ischemia injury and sympathetic nerve diseases
  • Use of NONRATT021972 small interfering RNA in preparation of drug for treating myocardial ischemia injury and sympathetic nerve diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Using methods well known in the art, make suitable for involving cervical sympathetic ganglion or myocardial P2X 7 Oral, injection or local application (contained, etc.) long non-coding ribonucleic acid NONRATT021972 small interfering ribonucleic acid preparation for the prevention and treatment of receptor-mediated myocardial ischemic injury (acute coronary syndrome, etc.).

Embodiment 2

[0025] Using methods well known in the art, make suitable for involving cervical sympathetic ganglion or myocardial P2X 7 Oral, injectable, or topically applied long noncoding RNA NONRATT021972 small interfering ribonucleic acid formulations for receptor-mediated prophylaxis of hypertension.

Embodiment 3

[0027] Using methods known in the art, make suitable for involving cervical sympathetic ganglion P2X 7 Oral, injectable or topically applied long non-coding RNA NONRATT021972 small interfering ribonucleic acid preparation for receptor-mediated prophylactic treatment of sympathetic nervous system disorders.

[0028] In order to better understand the essence of the present invention, the following long non-coding ribonucleic acid NONRATT021972 small interfering ribonucleic acid pair P2X 7 Experiments and results of receptor-mediated myocardial ischemic injury and sympathetic nerve stimulation to prove the use of NONRATT021972 small interfering ribonucleic acid.

[0029] 1. Materials and methods.

[0030] 1. Animals and grouping.

[0031] Healthy Sprague-Dawley (SD) rats (body weight 180-220g), male, were provided by the Department of Experimental Animal Science, School of Medicine, Nanchang University. Rats were randomly divided into control group; sham operation group; myoca...

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Abstract

The invention discloses a use of a long non-coding ribonucleic acid NONRATT021972 small interfering RNA in preparation of a drug for treating myocardial ischemia injury and sympathetic nerve diseases. Myocardial ischemia causes sympathetic nervous excitement reflex (such as blood pressure rising and heart rate and breathing acceleration) and further aggravates myocardial ischemia injury. Sympathetic nervous erethism can cause vasoconstriction function change thereby causing cardiovascular diseases. The long non-coding ribonucleic acid NONRATT021972 small interfering RNA can reduce myocardial ischemia and hypoxia exacerbation caused by myocardial ischemia injury-caused sympathetic nerve reflex, reduce myocardial ischemial injury, inhibit superior cervical ganglia erethism transmission, prevent and treat cardiovascular dysfunction-caused diseases, inhibit sympathetic nervous erethism and related pathological process and prevent and treat sympathetic nerve diseases. The long non-coding ribonucleic acid NONRATT021972 small interfering RNA in forms of an oral medicine, an injection, a lozenge or other local or whole body agents can treat the above diseases.

Description

technical field [0001] The invention belongs to the invention field of drug use for myocardial ischemia injury, cardiovascular and sympathetic nervous system diseases. Background technique [0002] Acute myocardial ischemia is usually caused by an imbalance between myocardial oxygen demand and oxygen supply caused by coronary artery occlusion or impending occlusion. Acute coronary syndrome refers to a series of symptoms caused by acute myocardial ischemia, including myocardial infarction (ST-segment elevation and depression, Q wave type and no Q wave type) and unstable angina. Clinical studies have found that the removal of sympathetic ganglia such as superior cervical ganglion (SCG) and stellate ganglion (SG) can make angina symptoms disappear in 50-60% of patients with coronary heart disease, suggesting that the sympathetic nerve that innervates the heart is involved Myocardial ischemic injury response. The heart is controlled by the cardiac sympathetic nerve and the car...

Claims

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Application Information

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IPC IPC(8): A61K48/00A61K31/713A61P9/10A61P9/12A61P25/02
Inventor 梁尚栋涂桂花彭海英李桂林刘双梅徐宏张君孔繁君刘俊
Owner NANCHANG UNIV
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