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Femur middle-lower section bone defect model as well as constructing method and application thereof

A construction method and technology for bone defects, applied in veterinary instruments, veterinary surgery, medical science, etc., can solve the problem of inability to complete large-scale bone defect research, large-scale bone biomaterials and implant research, and affect the reliability of experimental results. , can not be ruled out and other problems, to achieve the effect of simple preparation method, unaffected activities, and prevention of infection

Inactive Publication Date: 2016-01-06
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bone defects of the radius, fibula, and skull are limited to the size of their own bones, and it is impossible to complete the research on large-size bone defects and the research on related large-size bone biomaterials and implants
Moreover, the radius and tibia are anatomically accompanied by the ulna and fibula respectively. Although the periosteum of the radius or tibia of the corresponding length was resected in the process of making the model, the periosteum of the ulna or fibula that is closely adjacent to it cannot be ruled out during the bone healing process. Osteogenesis to the bone defect area, and the bone formation effect of this membranous osteogenesis will inevitably affect the reliability of the experimental results

Method used

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  • Femur middle-lower section bone defect model as well as constructing method and application thereof
  • Femur middle-lower section bone defect model as well as constructing method and application thereof
  • Femur middle-lower section bone defect model as well as constructing method and application thereof

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Embodiment 1

[0033] figure 1 The flow chart of the construction method of the bone defect model of the middle and lower part of the femur provided by the embodiment of the present invention, combined with figure 1 , the present embodiment provides a method for constructing a bone defect model in the middle and lower part of the femur, comprising the steps of:

[0034] (1) Expose the middle and lower part of the femur:

[0035] Six-month-old SD (Sprague Dawley) rats, both male and female, were taken as experimental animals, and were fed adaptively for 1 week. The experimental mice were anesthetized by intraperitoneal injection of chloral hydrate at a dose of 300 mg / kg. After successful anesthesia, the animals were fixed in the prone position on the animal experiment operating table, the hind limbs were removed with depilatory cream, and the operation area was disinfected and draped. Take the middle, lower, and anterolateral sides of the femur, but do not cut off the ligaments, cut the sk...

Embodiment 2

[0040] A method for constructing a bone defect model in the middle and lower part of the femur, comprising the steps of:

[0041] (1) Expose the middle and lower part of the femur, and the operation steps are the same as in Example 1;

[0042] (2) Use orthopedic micro-drills to resect the periosteum and diaphysis of the corresponding size in the middle and lower part of the femur, remove femurs of different diameters, create bone defects, and put in orthopedic biomaterials of corresponding sizes, wherein the diameter of the resected femur is 2mm, Orthopedic biomaterials are specifically silicate bioglass rod-shaped scaffolds;

[0043] After the operation was completed, the wound was washed with normal saline, the sarcolemma and subcutaneous tissue, the incision were sutured, and the incision was sterilized. After suturing, the dressing was bandaged to obtain the bone defect model of the middle and lower segment of the femur; no fixation was performed after the operation, and t...

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Abstract

The invention provides a constructing method of a femur middle-lower section bone defect model. The constructing method of the bone defect model comprises the following steps: (1) taking preserved skin from posterior limb of an anesthetized animal and disinfecting the preserved skin, and making incisions on middle, lower and front outer sides of femur of the animal to expose the middle-lower section of the femur; and (2) exciding femurs differing in size from the middle-lower section of the femur to form bone defect, irrigating wounds, dressing and stitching so as to obtain the femur middle-lower section bone defect model. On a femur middle-lower section bone defect operative approach, important blood vessels and nerves are avoided, so that secondary injury and bleeding are relieved in a process of establishing the bone defect model to the greatest extent; and the model is good in unity and repeatability, and is conducive to simulating a clinical bone defect repairing effect. The invention also provides a femur middle-lower section bone defect model prepared based on the method and application of the bone defect model.

Description

technical field [0001] The invention relates to the fields of medical evaluation and medical detection, in particular to a bone defect model of the middle and lower part of the femur and its construction method and application. Background technique [0002] In the field of tissue engineering research, standardized animal models are an indispensable part of experimental research, and are a necessary carrier for evaluating the performance of biomaterials, the quality of construction strategies, and observing the mechanism of seed cell fate. The treatment of bone defects has always been a difficult point in orthopedics, plastic surgery, and maxillofacial surgery, and has also been a research focus and hotspot for a long time. Establishing a reasonable bone defect animal model is an important link in the research. [0003] Common bone defect models mainly include bone defect models such as radius and tibia, but no mouse femur bone defect model has been seen. Bone defects of the...

Claims

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Application Information

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IPC IPC(8): A61D1/00
Inventor 王磊张利吕维加潘浩波彭松林
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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