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X-ray imaging at low contrast agent concentrations and/or low dose radiation

A contrast agent and ray technology, applied in the field of X-ray inspection, can solve problems such as side effects, and achieve the effects of large cost savings, reduced treatment costs, and cost savings

Inactive Publication Date: 2015-12-30
GE HEALTHCARE AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, in coronary angiography, bolus doses of contrast media injected into the circulation can have serious side effects

Method used

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  • X-ray imaging at low contrast agent concentrations and/or low dose radiation
  • X-ray imaging at low contrast agent concentrations and/or low dose radiation
  • X-ray imaging at low contrast agent concentrations and/or low dose radiation

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0092] Example 1: Effect of low kVp computed tomography (CT) on contrast-to-noise ratio (CNR) without special noise reduction methods:

[0093] Schindera et al (2008) Hypervascular liver tumors: low tube voltage, high tube current multi-row detector CT for enhanced detection-simulation model studies. Radiology(246): January 2008, Issue 1 Evaluation of low tube voltage, high tube current computed tomography (CT) technology on image noise, contrast-to-noise ratio (CNR), contrast-to-noise ratio (CNR), Lesion visibility and radiation dose effects.

[0094] This phantom consists of four cavities (3, 5, 8 and 15 mm in diameter) filled with various iodized solutions to simulate hypervascular liver lesions using a 64-segment multi-row detector CT scanner at 140, 120, 100 and 80kVp sweeps, where the corresponding tube current-time product settings were 225, 275, 420 and 675mAs, respectively. The results show that the radiation dose can be greatly reduced by using 80kVp. Furthermore,...

example 2

[0101] Example 2: Effect of low kVp computed tomography (CT) on image attenuation without special noise reduction methods

[0102] The inventors evaluated the effect of low tube voltage on iodine CNR in a resting simulation model. The phantom contained cavities filled with various iodinated solutions (0-12 mgl / ml) to simulate filled blood vessels, and this was scanned with a GEHD750CT at 120 and 80 kVp. No adaptive statistical or model-based reconstruction (ASiR / MBiR) results show that attenuation at 120 kVp ~ 250 Hounsfield Units (HU) is achieved with 9.5 mgl / ml iodinated contrast media, whereas at 80 kVp for the same attenuation Only 6 mgl / ml is required. This confirms that iodine HU values ​​are larger at lower kVps due to the increased attenuation coefficient of iodine at lower X-ray energies - see figure 1 , which shows the effect of low kVp on decay at different iodine concentrations. Such data suggest that additional reconstruction with ASiR / MBiR will further enhance...

example 3

[0103] Example 3: Maintenance of Low kVp Image Quality (IQ)

[0104] This example shows that high milliamps (mA) are not needed when using low kVp to boost image quality. Special preparation-based data processing improves image fidelity while maintaining low kVp image quality (IQ).

[0105]In an additional phantom study, a 32 cm polymethylmethacrylate (PMMA) phantom was used with 10 mg / ml iodine, and noise was measured at the center of the phantom. In this study, a GEHD750 system using special preparation-based data processing to improve low signal level performance and boost image fidelity while maintaining low kVp image quality delivered the same Image quality (IQ, CNR). In fact using the GEHD750CT 80kVp and 300mAs compared to 13.8 at 120kVp and 300mAs resulted in a contrast to noise ratio (CNR) of 13.5, showing that the CNR is maintained at lower kVp. Such data suggest that high mA is not required at 80kVp and that 0-500mA is sufficient in iodine contrast studies. Other...

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Abstract

The present invention relates to X-ray examinations and to the improvement of patient safety during such. More specifically the invention relates to X-ray diagnostic compositions having ultra-low concentrations of iodine. The invention further relates to methods of X-ray examinations wherein a body is administered with an X-ray diagnostic composition and irradiated with a reduced radiation dose.

Description

technical field [0001] The present invention relates to X-ray examinations and the improvement of patient safety during these. More specifically, the present invention relates to X-ray diagnostic compositions having ultra-low iodine concentrations. The invention also relates to a method of X-ray examination, wherein the body is administered an X-ray diagnostic composition and irradiated with a reduced radiation dose. In a particular embodiment, the present invention relates to an X-ray diagnostic composition having an ultra-low iodine concentration and a method of X-ray examination using the same, wherein the body to which the composition is administered is irradiated with a reduced dose of X-ray radiation. According to. Background technique [0002] All diagnostic imaging is based on achieving different signal levels from different structures within the body so that these structures can be visualized. Thus, in eg X-ray imaging, for a given body structure to be visible in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/04A61B6/00
CPCA61K49/0438A61P43/00A61K49/04A61K49/10A61B6/035A61B6/40A61B6/481A61B6/5258A61M5/007
Inventor C.凯泽B.牛顿
Owner GE HEALTHCARE AS
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