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Skin whitening and fleck removing skin-care composition

A skin care composition and the technology of the composition are applied in the field of whitening and light-spot cosmetic compositions, and can solve problems such as troxerutin not seen

Active Publication Date: 2015-12-30
GUANGZHOU GAOZI COSMETICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Although troxerutin is synthesized from rutin and has a similar chemical structure to rutin, it has not been seen that troxerutin is used for whitening, brightening skin tone, inhibiting melanin, and inhibiting tyrosine Enzymes are reported, in contrast troxerutin is widely used in tanning formulations, such as Merck's self-tanning formulation containing dihydroxyacetone and troxerutin

Method used

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  • Skin whitening and fleck removing skin-care composition
  • Skin whitening and fleck removing skin-care composition

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0085] Measuring the effect of inhibiting melanin formation

[0086] HM3KO cells, which are human melanoma cells, were placed in minimal essential medium containing 10% bovine embryonic serum, and cultured at 37°C and 5% CO2. Smear the cultured cells on the bottom of a 75-well flask, the number of cells is 3×105 / well, and let it stand overnight, so that the cells can adhere to the wall. After confirmation, each medium was changed to a new medium containing 10 ppm of the experimental sample.

[0087] The experimental samples used are shown in Table 1 below.

[0088] The medium containing DMSO (dimethyl sulfoxide) was used in the control group.

[0089] In the manner described above, change each medium to a new medium containing the experimental sample once every 2 days until the cultured cells are sufficient to fill the flask. Then, the medium fluid was taken out, washed with PBS (phosphate buffer solution), and then dissolved in 1N NaOH, and the optical density (OD) at 500...

experiment example 2

[0095] Skin Whitening Effect on Human Skin

[0096] An opaque adhesive tape with 6 holes with a diameter of 1.5 cm was adhered to the upper arms of each of 10 healthy men and irradiated with an ultraviolet beam at an intensity of 1.5-2 times the lowest erythema dose for each subject to Induces skin melanin deposition. Then apply the test sample, and after 2 months, measure the depth of the skin using a colorimeter.

[0097] The experimental samples were prepared according to the composition in Table 1, and the formulations of the examples and comparative formulations in Table 1 were applied twice a day (once in the morning and once in the evening).

[0098] table 3

[0099] Matrix formulation

[0100]

[0101] Table 3 Active substance ratio

[0102]

[0103] The experimental results are shown in the table below

[0104] Table 4

[0105] Experimental sample

Skin whitening effect (ΔL)

Preparation 1

1.02

Preparation 2

1.21

Pr...

Embodiment 1

[0109] Butanediol 6.0

[0110] Methylparaben 0.12

[0111] Hydroxyethyl cellulose 0.2

[0112] Polyquaternium-100.05

[0113] Troxerutin 1.5

[0114] Disodium EDTA 0.15

[0115] Allantoin 0.15

[0116] Serine 2.0

[0117] Trimethylglycine 2.5

[0118] Carbomer 0.4

[0119] Caprylic / Capric Triglyceride 6.35

[0120] Cetearyl Glucoside 0.75

[0121] Cetearyl Alcohol 2.0

[0122] PEG-100 Stearate 1.0

[0123] Monoglyceride Stearate 1.0

[0124] PEG-75 lanolin 0.2

[0125] Polydimethylsiloxane 2.0

[0126] Bisabolol 0.35

[0127] Tocopheryl Acetate 2.0

[0128] Sapindoside 2.0

[0129] Ginsenoside 0.4

[0130] Niacinamide 4.0

[0131] Antiallergic Agent 2.0 (sold under the trade name U-activeP8 by Wooai Korea)

[0132] Phenoxyethanol 0.5

[0133] Flavor 0.35

[0134] Glycerin 4.0

[0135] Urea 0.2

[0136] Papain 3.0

[0137] Water to 100.

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PUM

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Abstract

The invention relates to skin whitening and fleck removing skin-care cosmetic composition. The composition can prevent excessive generation of melanin and realizes effects of skin whitening, fleck removing and skin brightening. Specifically, the skin whitening and fleck removing skin-care cosmetic composition contains troxerutin, sapindoside and papain. The composition realizes the effects of skin whitening, blackspot removal and skin brightening through synergistic effects of troxerutin, sapindoside and papain.

Description

technical field [0001] The invention relates to a skin care cosmetic composition for whitening and lightening spots. Specifically, the cosmetic composition for whitening and lightening spots of the present invention contains troxerutin, sapindus saponin and papain. Through the synergistic effect of troxerutin, sapindus saponin and papain, the composition achieves the excellent effects of whitening skin, lightening blemishes and brightening skin tone. Background technique [0002] When people's skin is irradiated by ultraviolet rays, melanin, which determines the color of human skin, is produced and released, thereby causing hyperpigmentation, such as melasma, freckles and spots, which have adverse effects on beauty. [0003] The synthesis process of melanin is as follows: tyrosinase in cells acts on tyrosine to form dopaquinone, thereby producing melanin. Therefore, in order to prevent darkening of the skin, researchers have devoted themselves to studying the inhibition of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/66A61K8/60A61Q19/00A61Q19/02
CPCA61K8/602A61K8/66A61K2800/782A61Q19/00A61Q19/02
Inventor 韩勇
Owner GUANGZHOU GAOZI COSMETICS CO LTD
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