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Preparation method for magnetic carbon microsphere surface cephalexin molecular imprinted adsorbent material

A technique for cephalexin molecules and imprinted adsorption, applied in chemical instruments and methods, alkali metal oxides/hydroxides, inorganic chemistry, etc.

Active Publication Date: 2015-12-23
HENAN UNIV OF URBAN CONSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Preparation method for magnetic carbon microsphere surface cephalexin molecular imprinted adsorbent material
  • Preparation method for magnetic carbon microsphere surface cephalexin molecular imprinted adsorbent material
  • Preparation method for magnetic carbon microsphere surface cephalexin molecular imprinted adsorbent material

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Embodiment 1

[0021] (1) Preparation of magnetic carbon microspheres

[0022] Select walnut shells and dry them at a temperature of 115° C. for 18 hours, and crush the dried walnut shells to a particle size of about 2.0-4.0 mm to obtain raw material particles. Pass the above-mentioned walnut shell particles through 3.0mol / L hydrochloric acid, reflux at 70°C for 12 hours, wash with distilled water several times to neutralize, and dry at 60°C until constant weight to obtain acid-activated walnut shell particles.

[0023] The acid-activated walnut shell particles prepared above were mixed with FeCl 3 .6H 2 O, sodium acetate according to the acid activation of walnut shells: FeCl 3 .6H 2 O: Sodium acetate is dissolved in ethylene glycol at a ratio of 1.0: 0.5: 2.0 (g / g / g), and the amount of ethylene glycol is activated according to the acid activated walnut shell: ethylene glycol=1.0: 100 (g / ml ), ultrasonically stirred for 30min, mixed evenly, then added polyethylene glycol to the above-me...

Embodiment 2

[0032] Take 25ml of cephalexin solutions with initial concentrations of 5, 10, 20, 30, 50, 60, 80, 100, 150, 200, and 300 μmol / L and add them to the centrifuge tube, and add 10 mg of magnetic carbon microsphere surface imprinted adsorbent and non-imprinted adsorbent, put the test solution in a water bath at 25°C and let it stand for 24.0h, then separate and collect the supernatant with a Nd-Fe-B permanent magnet, and measure the molecular concentration of unadsorbed cephalexin with a UV-visible spectrophotometer , to calculate the adsorption capacity, figure 1 The results show that the saturated adsorption capacity of the imprinted adsorbent is 52.35umol / g higher than that of the non-imprinted adsorbent 19.36umol / g, which proves that the imprinted adsorbent has a large number of imprinted holes and shows a good imprinting effect.

Embodiment 3

[0034] Take 25ml of cephalexin solution with an initial concentration of 150 μmol / L and add it to a centrifuge tube, add 10 mg of magnetic carbon microsphere surface imprinted adsorbent and non-imprinted adsorbent, and place the test solution in a water bath at 25°C for 2 and 5 minutes respectively. , 10, 20, 30, 45, 60, 90, 120 and 150min, after standing still, the supernatant was separated and collected by Nd-Fe-B permanent magnet, and the molecular concentration of unadsorbed cephalexin was measured by UV-visible spectrophotometer Determination, calculate the adsorption capacity, from figure 2 It can be seen that at the beginning, with the increase of adsorption time, the adsorption capacity increased rapidly, and the adsorption reached equilibrium after 30 min. In the whole adsorption time range, the adsorption capacity of cephalexin molecules by the imprinted adsorbent on the surface of magnetic carbon microspheres was greater than that of the non-imprinted adsorbent. Fo...

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Abstract

The present invention relates to a preparation method for a magnetic carbon microsphere surface cephalexin molecular imprinted adsorbent material. The method comprises: taking a walnut shell as a carbon source to prepare a magnetic carbon microsphere; carrying out ethylene functionalized modification on the surface of the magnetic carbon microsphere by use of 3-(methacryloxy)propyl trimethoxysilane; taking cephalexin (CFX) as a template molecule, methacrylic acid (MAA) as a functional monomer, ethylene alcohol dimethacrylate (EGDMA) and N, N- methylene bisacrylamide (BIS) as a crosslinking agent, and cetane as a porogenic diluent and an organic solvent to prepare a magnetic carbon microsphere surface imprinted adsorbent. The magnetic carbon microsphere surface imprinted adsorbent material prepared by the method disclosed by the invention is low in cost and simple in preparation, and has high recognition, high selectivity, and high separation enrichment capacity on target molecules, and a high absorption speed.

Description

technical field [0001] The invention relates to a preparation method of a cephalexin molecularly imprinted adsorption material on the surface of magnetic carbon microspheres, and belongs to the technical field of preparation of environmental functional materials. Background technique [0002] Cefalexin antibiotics belong to β-lactam drugs, which have the advantages of broad antibacterial spectrum, strong antibacterial effect, and resistance to penicillinase. It is commonly used in the treatment of sepsis, meningitis and endocarditis in animal husbandry. Irrational use causes these drugs to accumulate in tissues of animal origin. After people eat these animal-derived foods, allergic reactions and even shocks occur, which pose a serious threat to human health. The abuse of a large number of drugs will also lead to the emergence of drug-resistant strains and destroy the ecological environment. How to separate these drug residues has become an urgent problem to be solved, esp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30B01J20/28
Inventor 毛艳丽康海彦罗世田吴俊峰王红强王增欣郭一飞陈松涛
Owner HENAN UNIV OF URBAN CONSTR
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