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Preparation method of spherical mesoporous carbon for blood purification

A blood purification and spherical technology, applied in chemical instruments and methods, other chemical processes, dialysis systems, etc., can solve problems such as unsuitable adsorbents for blood purification, clogging blood vessels, affecting cardiovascular system functions, etc., to achieve good blood phase Capacitance, good sphericity, and good blood compatibility

Inactive Publication Date: 2015-12-09
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This patent uses highly corrosive hydrofluoric acid to etch the hard template, which is not suitable for use as an adsorbent for blood purification, because the residual hydrofluoric acid has a corrosive effect on the skin, eyes, respiratory and digestive tract mucous membranes, and fluoride ions enter the blood Or tissues can combine with calcium and magnesium ions to form insoluble or slightly soluble calcium fluoride and magnesium fluoride, which may block blood vessels and directly or indirectly affect the function of the cardiovascular system

Method used

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  • Preparation method of spherical mesoporous carbon for blood purification
  • Preparation method of spherical mesoporous carbon for blood purification
  • Preparation method of spherical mesoporous carbon for blood purification

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0029] First, dilute the commercially available water glass to 3%, and pass it through a cation exchange resin column to obtain an active silicic acid solution, add sodium hydroxide solution to adjust the pH to 9.5, hydrolyze at a constant temperature of 40°C for 4 hours, and reach the silica sol with the required particle size, concentrate to 30% Alkaline SiO 2 Sol. Then resorcinol, formaldehyde and SiO 2 Mix at a molar ratio of 1:2:3, add a certain amount of deionized water so that the total concentration of organic matter in the reactant is 20g / 100mL, polymerize at 40°C for 70min to form an organic-inorganic sol, pour it into paraffin oil, and stir to form spheres, and further aged at 85 °C to obtain spherical composite hydrogels. Separated and washed, and then dried under normal pressure. Under the protection of nitrogen, carbonization and cracking at 900°C for 2 hours resulted in spherical carbon-silicon composite airgel. Then the spherical carbon-silicon composite ai...

Embodiment 2

[0031] First, dilute the commercially available water glass to 8%, pass it through a cation exchange resin column to obtain an active silicic acid solution, add sodium hydroxide solution to adjust the pH to 9, hydrolyze at a constant temperature of 50°C for 0h, and concentrate to a concentration of 30% alkaline SiO 2 Sol. Then resorcinol, formaldehyde and SiO 2 Mix evenly at a molar ratio of 1:2:3, add a certain amount of deionized water so that the total concentration of organic matter in the reactant is 20g / 100mL, polymerize at 50°C for 60min to form an organic-inorganic sol, pour it into silicone oil, and stir to form spheres, and further aged at 80 °C to obtain spherical composite hydrogels. Separated and washed, and then dried under normal pressure. Under the protection of nitrogen, carbonization and cracking at 850°C for 2.5 hours was carried out to obtain spherical carbon-silicon composite airgel. Then soak the spherical carbon-silicon composite airgel in 15% sodium ...

Embodiment 3

[0033] First, dilute the commercially available water glass to 10%, pass it through a cation exchange resin column to obtain an active silicic acid solution, add sodium hydroxide solution to adjust the pH to 9.5, hydrolyze at a constant temperature of 60°C for 2 hours, and reach the silica sol with the required particle size, and then concentrate to 30% Alkaline SiO 2 Sol. Then resorcinol, formaldehyde and SiO 2 Mix evenly at a molar ratio of 1:2:4, add a certain amount of deionized water so that the total concentration of organic matter in the reactant is 15g / 100mL, polymerize at 60°C for 35min to form an organic-inorganic sol, pour it into paraffin oil, and stir Balls were formed and further aged at 75 °C to obtain spherical composite hydrogels. Separated and washed, and then dried under normal pressure. Under the protection of nitrogen, carbonization and cracking at 800°C for 3 hours resulted in spherical carbon-silicon composite airgel. Then soak the spherical carbon-s...

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Abstract

The invention relates to a preparation method of spherical mesoporous carbon for blood purification. The preparation method comprises the following steps: synthesizing SiO2 nano sol by taking water glass as a raw material, uniformly mixing the SiO2 nano sol with resorcinol-formaldehyde, performing prepolymerization to form organic-inorganic gel, adding the gel into a dispersing phase to form spherical organic-inorganic compound gel under the stirring action, then performing separation and cleaning, and performing sodium hydroxide etching through high-temperature carbonization after normal pressure drying, thus obtaining the spherical mesoporous carbon. Compared with the prior art, the preparation method disclosed by the invention has the advantages that the preparation cost is low, the conditions are simple, the operation is easy, and the prepared spherical mesoporous carbon is high in sphericity, controllable in particle size, rich in pore structure, smooth in surface, high in intensity, low in ash content, high in abrasion resistance, high in blood compatibility and the like.

Description

technical field [0001] The invention relates to the field of carbon materials, in particular to a method for preparing spherical mesoporous carbon for blood purification. Background technique [0002] Hemoperfusion is an important part of blood purification therapy, which refers to a treatment that introduces the patient's blood into a container with a solid adsorbent, removes some exogenous and endogenous toxins, and returns the purified blood to the body method. Hemoperfusion can effectively remove creatinine, uric acid, middle molecular substances, phenols, guanidines, indoles, organic acids and various drugs in the blood. At the heart of this therapy is a solid-state sorbent. The most commonly used adsorbents are activated carbon and resins. However, the resin adsorbent has poor stability, is easy to dissolve polymerized monomers, and has poor blood compatibility. It often shows side effects such as decreased platelets, decreased white blood cells, and decreased blood...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/20B01J20/30A61M1/14
Inventor 龙东辉种艳平陈明奇王际童乔文明凌立成
Owner EAST CHINA UNIV OF SCI & TECH
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