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Traditional Chinese medicine composition for treatment of nephritic syndromes and chronic renal failure and preparation method of traditional Chinese medicine composition

A technology for chronic renal failure and nephrotic syndrome, which can be used in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as heavy economic burden on patients

Inactive Publication Date: 2015-12-09
JIANGNAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Renal failure progresses to the end stage, and the renal function cannot maintain the excretion activities of normal life, which means that hemodialysis or kidney transplantation is required, which brings a heavy economic burden to the patient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] a. Crush 60 parts of hollyhock flowers to 70 mesh, extract 4 times with 20 times the amount of water at 80° C., each extraction time is 3 hours, and filter to obtain a water extract. The filter residue was continuously extracted 3 times with 20 times of 95% ethanol under reflux, and the extraction time was 2 hours each time;

[0017] b. The water extract and alcohol extract obtained in step a are concentrated under reduced pressure to extracts with a specific gravity of 1.1 to 1.35, and filtered to obtain water extract extracts and alcohol extract extracts; The paste and the alcohol extract are mixed according to the mass ratio of 1:1, and dried in vacuum at a temperature of 80°C for 48 hours to obtain a dry extract, which is crushed and added to Paecilomyces spp. (Paecilomyceshepialid) 40 parts of Cs-4 fermented bacterium powder were added with suitable common excipients to make a hard capsule preparation.

Embodiment 2

[0019] a. Mix and grind 36 parts of hollyhock flowers to 60 mesh, extract 3 times with 5 times the amount of water at 95° C., each extraction time is 1 hour, and filter to obtain a water extract. The filter residue was continuously extracted 3 times with 15 times of 95% ethanol under reflux, and the extraction time was 1 hour each time;

[0020] b. The water extract and alcohol extract obtained in step a are concentrated under reduced pressure to extracts with a specific gravity of 1.1 to 1.35, and filtered to obtain water extract extracts and alcohol extract extracts; The paste and the alcohol extract are mixed according to the mass ratio of 1:2, and dried in vacuum at a temperature of 60°C for 48 hours to obtain a dry extract, which is crushed and added with Trichosporum sinensis (Hirsutella inensis) 25 parts of fermented bacteria powder are added with suitable common auxiliary materials to make granules.

Embodiment 3

[0022] a. Mix and pulverize 7 parts of hollyhock flowers to 40 mesh, extract once with 10 times the amount of water at 40° C., each extraction time is 2 hours, and filter to obtain a water extract. The filter residue was continuously extracted 4 times with 10 times of 95% ethanol under reflux, and the extraction time was 2 hours each time;

[0023] b. The water extract and alcohol extract obtained in step a are concentrated under reduced pressure to extracts with a specific gravity of 1.1 to 1.25, and filtered to obtain water extract extracts and alcohol extract extracts; The paste and the alcohol extract are mixed according to the mass ratio of 2:3, and dried in vacuum at a temperature of 30°C for 48 hours to obtain a dry extract, which is crushed and added to Paecilomyces spp. (Paecilomyceshepialid) 5 parts of Cs-4 fermented bacteria powder are added with suitable common excipients to make tablets.

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Abstract

The invention relates to traditional Chinese medicine composition for treatment of nephritic syndromes and chronic renal failure and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is composed of, by weight, 1-70 parts of fermented cordyceps sinensis powder and 1-60 parts of abelmoschus manihot extracts. Effective components of the traditional Chinese medicine composition are dissolved out by a reasonable extraction method, effect enhancement is realized, and bioavailability is improved. Furthermore, the traditional Chinese medicine composition has specific treatment effects on the nephritic syndromes, chronic renal failure and the like caused by various pathological types and various reasons including glomerulus diseases, secondary systemic diseases, diabetic complications and the like.

Description

technical field [0001] The invention relates to a combination of traditional Chinese medicines, in particular to a combination of traditional Chinese medicines for treating nephrotic syndrome and chronic renal failure and a preparation method thereof. Background technique [0002] Nephrotic syndrome is caused by a variety of diseases. It is a group of syndromes dominated by glomerular lesions such as increased glomerular filtration membrane permeability and loss of a large amount of plasma protein in urine. The clinical manifestations of the patient were massive proteinuria, hypoalbuminemia, hypercholesterolemia, and obvious edema. Generally, nephrotic syndrome can be diagnosed in patients with clinical features such as massive proteinuria greater than 3.5g / d, low plasma protein less than 30g / L, obvious edema, and hyperlipidemia (serum cholesterol) greater than 6.5mmol / L. Nephrotic syndrome belongs to "edema" and "consumption of deficiency" in traditional Chinese medicine. ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P13/12
Inventor 许正宏史劲松陆震鸣任怡琳唐海涛徐柏颐朱善意丛旭东
Owner JIANGNAN UNIV
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