Method for catalytically synthesizing phenazine compounds in water phase under microwave radiation

Abstract

The invention discloses a method for catalytically synthesizing phenazine compounds in a water phase under microwave radiation, which comprises the following steps: adding a catalytic amount of catalyst ferric chloride or nickelous chloride, a cocatalyst lithium proline, a substrate substituted 2-haloaniline, a phase-transfer catalyst 4-butyl ammonium chloride, 4-butyl ammonium bisulfate or 4-butyl ammonium bromide, an inorganic alkali or organic alkali and water into a reaction vessel, putting into a microwave reaction instrument, reacting at certain temperature under certain power for some time, concentrating under reduced pressure, and purifying the product by column chromatography. The method for preparing phenazine compounds is friendly to the environment, simple to operate and high in efficiency. Compared with the prior art, the method has the advantages of obviously higher reaction speed than conventional heating, mild reaction conditions, high yield, high safety, low cost and environment friendliness, and is simple to operate.

Description

technical field [0001] The present invention relates to a method for the preparation of phenazine derivatives. That is, using substituted 2-halogenated arylamines as raw materials, introducing microwaves as an auxiliary synthesis method, and efficiently catalyzing and rapidly preparing phenazine compounds. Background technique [0002] As a class of nitrogen-containing fused heterocyclic compounds, phenazine has a certain special status in the field of organic chemistry. It is a dyeable substance obtained by chemical methods for the first time. Later, it was discovered that phenazine was biologically active and could be used as a fungicide. In recent years, phenazine has been used more and more widely, such as in antitumor drugs, antibacterial, molecular optical switches, solar energy conversion and polymer materials, and has attracted more and more attention in the fields of medicine, energy and materials. [0003] The methods for synthesizing phenazine compounds reported...

AI Technical Summary

Problems solved by technology

The synthesis methods of phenazine compounds currently reported have their own advantages and disadvantages, and their use is more or less limited due to the difficulty in obtaining raw materials, the high toxicity of some reagents, the severe reaction conditions and serious environmental pollution.

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