Noninvasive measuring method of microstructure of biological tissue

A technology of biological tissue and measurement method, applied in diagnostic recording/measurement, medical science, sensor, etc., can solve the problem of not correctly reflecting the anisotropic diffusion characteristics of water molecules, unable to distinguish diffusion motion, and unable to provide different tissue composition structures Information and other issues, to achieve the effect of good diffusion characteristics

Inactive Publication Date: 2015-11-25
PEKING UNIV THIRD HOSPITAL
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Problems solved by technology

However, diffusion-weighted imaging provides the apparent diffusion coefficient (ADC) of each biological tissue component. The description method of this scalar quantity does not correctly reflect the anisotropic diffusion characteristics of water molecules in biological tissue components.
Different from MRI diffusion-weighted imaging, diffusion tensor imaging can well analyze the anisotropic diffusion characteristics of water molecules in the brain, but it cannot distinguish the diffusion motion of water molecules in different tissue components, so it cannot provide the information of different tissue components. structure information

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  • Noninvasive measuring method of microstructure of biological tissue
  • Noninvasive measuring method of microstructure of biological tissue
  • Noninvasive measuring method of microstructure of biological tissue

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[0026] In order to have a clearer understanding of the technical features, purposes and effects of the invention, the specific implementation manners of the present invention will now be described with reference to the accompanying drawings, in which the same reference numerals represent the same parts. The following is an example of magnetic resonance imaging of brain tissue.

[0027] In this article, "schematic" means "serving as an example, example or illustration", and any illustration or implementation described as "schematic" should not be interpreted as a more preferred or more advantageous Technical solutions.

[0028] Herein, although the implementation object of each embodiment is brain tissue, it is not limited to brain tissue, and the non-invasive measurement method of biological tissue microstructure can also be implemented in other biological tissues.

[0029] The non-invasive measurement method for the microstructure of biological tissue includes the following ...

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Abstract

Disclosed is a noninvasive measuring method of microstructure of biological tissue. The noninvasive measuring method includes: performing magnetic resonance diffusion-weighted imaging on the biological tissue; measuring actual image signal strength of each pixel point in each magnetic resonance image; according to the actual image signal strength and calculated image signal strength, solving to acquire extracellular clearance volume ratio, cell volume ratio, blood vessel volume ratio, intracellular diffusion vector in a diffusion-weighted vector direction, blood diffusion vector in the diffusion-weighted vector direction and extracellular clearance diffusion vector in the diffusion-weighted vector direction of each pixel point in the magnetic resonance images; restructuring magnetic resonance images. By the noninvasive measuring method, structural information of different tissue components can be provided, and anisotropic diffusion characteristics of water molecules in the tissue can be analyzed well.

Description

technical field [0001] The invention relates to a method for measuring biological microstructure, in particular to a non-invasive measurement method for measuring tissue microstructure through magnetic resonance imaging. Background technique [0002] Magnetic resonance imaging (MRI) has been widely used in the imaging of biological tissues such as the central nervous system and hepatobiliary system due to its characteristics of no ionization damage, high soft tissue resolution, and sensitivity to chemical components. With the application of new technologies such as magnetic resonance water molecular diffusion-sensitive imaging technology gradually matured, magnetic resonance diffusion weighted imaging (DWI) and magnetic resonance diffusion tensor imaging (DTI) appeared, and it has been possible to realize the detection of The isotropic diffusion coefficient and anisotropic diffusion tensor of water molecules are solved. [0003] When performing MRI diffusion weighted imagin...

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Application Information

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IPC IPC(8): A61B5/055
Inventor 韩鸿宾
Owner PEKING UNIV THIRD HOSPITAL
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