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Preparation method for nafcillin molecular imprinting adsorbent

A technology of nafcillin and molecular imprinting, applied in chemical instruments and methods, adsorption water/sewage treatment, alkali metal oxides/hydroxides, etc., can solve the problems of poor thermal stability and easy decomposition of β-lactam rings

Active Publication Date: 2015-11-18
HENAN UNIV OF URBAN CONSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the β-lactam ring in the chemical structure of such antibiotics has poor thermal stability and is easy to decompose under acidic conditions, and the carbon atoms on the carbonyl group are more likely to be attacked by affinity reagents. Therefore, most β-lactam antibiotics The environmental residues are generally 10 -9 Magnitude

Method used

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  • Preparation method for nafcillin molecular imprinting adsorbent
  • Preparation method for nafcillin molecular imprinting adsorbent
  • Preparation method for nafcillin molecular imprinting adsorbent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Activation of illite and vinyl functionalization

[0024] The massive illite is ground by a ball mill, passed through a 100-mesh sieve, calcined at 180°C for 24 hours, and then heated in 3.0mol / L HNO 3 The solution was refluxed at 80°C for 12.0h, the product was washed with distilled water until neutral, and dried at 120°C to obtain acid-activated illite.

[0025] According to the consumption ratio of acid activated illite, 3-(methacryloyloxy)propyltrimethoxysilane and toluene, acid activated illite: 3-(methacryloyloxy)propyltrimethoxysilane: toluene mass The ratio is 1.0:3.0:100 (g / g / g). Add the mixed solution into a three-necked flask, disperse it evenly by ultrasonic, put it in an oil bath at 90°C, and stir it vigorously for 24 hours. After the reaction is completed, cool it to room temperature. After washing with acetone, methanol and deionized water several times, and vacuum drying at 60°C, the vinyl-functionalized illite, illite-MPS, was obtained.

[0026] (2)...

Embodiment 2

[0034] Take 10 mL of nafcillin solution with an initial concentration of 0.0005 mmol / L to 0.1 mmol / L and add it to a centrifuge tube, add 5.0 mg of nafcillin molecularly imprinted adsorbent and non-imprinted adsorbent respectively, and place the test solution in a 25°C water bath Leave standstill in the pot for 24h, utilize the ultraviolet-visible spectrophotometer to measure the concentration of nafcillin in the solution after adsorption, calculate the adsorption capacity, figure 2 The results show that the saturated adsorption capacity of nafcillin by molecularly imprinted adsorbent and non-imprinted adsorbent is 2750 μg / g and 512 μg / g, respectively, indicating that molecularly imprinted adsorbent has larger adsorption capacity than non-imprinted adsorbent, It indicated that more specific binding sites were formed on the surface of nafcillin molecularly imprinted adsorbent during the imprinting process.

Embodiment 3

[0036] Take 10 mL of nafcillin solution with an initial concentration of 0.05 mmol / L and add it to a centrifuge tube, add 5.0 mg of nafcillin molecularly imprinted adsorbent and non-imprinted adsorbent, and place the test solution in a water bath at 25°C for 2 . image 3 It can be seen that, at the beginning, with the increase of adsorption time, the adsorption capacity increased rapidly, and the adsorption reached equilibrium after 60 min. In the whole range of adsorption time, the adsorption capacity of nafcillin molecularly imprinted adsorbent to nafcillin was greater than that of non-imprinted adsorbent to The adsorption capacity of nafcillin, the results showed that the imprinted sorbent exhibited higher adsorption capacity and faster mass transfer than the non-imprinted sorbent.

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Abstract

The invention relates to a preparation method for a nafcillin molecular imprinting adsorbent. The preparation method for the the nafcillin molecular imprinting adsorbent takes functionalized illite as a substrate, takes nafcillin as a template molecule, takes methylacrylic acid (MAA) as a functional monomer, takes N, N'-methylene bisacrylamide (MBAA) as a cross-linking agent, takes a catalyst copper chloride (CuCl2) and a ligand N, N, N', N", N"-pentamethyldiethylenetriamine (PMDETA) as a catalytic system, and takes ascorbic acid (AsAc) as a reducing agent through an atom transfer radical polymerization (AGET ATRP) process which adopts electron activation transfer to generate a catalyst; and the preparation method is used for selectively recognizing and separating nafcillin. The method is low in cost and simple in preparation, and a product has high recognition, high selectivity and high separation and enrichment capacity on a target molecule.

Description

technical field [0001] The invention relates to a preparation method of a nafcillin molecularly imprinted adsorbent, which belongs to the technical field of preparation of environmental functional materials. Background technique [0002] Molecularly imprinted polymers are polymers that can specifically recognize and selectively adsorb target molecules (template molecules) synthesized by molecular imprinting technology. Surface molecular imprinting technology solves the problem of incomplete removal of template molecules, small binding capacity and slow mass transfer, and active sites caused by high cross-linking in traditional bulk polymerization by establishing molecular recognition sites on or near the surface of the matrix material. The points are too deeply embedded, and the kinetic performance of adsorption-desorption is not good. [0003] Atom transfer radical polymerization is a kind of polymerization method in living controlled free radical polymerization. It has ce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30C02F1/28
Inventor 毛艳丽康海彦罗世田吴俊峰王红强王增欣郭一飞陈松涛
Owner HENAN UNIV OF URBAN CONSTR
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