Multifunctional mesoporous silica nanoparticles having near-infrared photothermal and in-vivo fluorescence imaging characteristics as well as preparation method and application of mesoporous silica nanoparticles

A technology of mesoporous silica and near-infrared light, which can be applied to preparations for in vivo experiments, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., which can solve the problem that nanomaterials do not have fluorescence imaging function. , the toxicity limit of precious metal copper sulfide, etc., to achieve excellent photothermal treatment effect, good photothermal conversion efficiency, and the effect of inhibiting tumor growth in vivo

Active Publication Date: 2015-11-18
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although both gold and copper sulfide can endow nanoparticles with photothermal therapy functions, the high cost of noble metals and the toxicity of copper sulfide limit their applications, and the nanomaterials do not have fluorescence imaging functions.

Method used

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  • Multifunctional mesoporous silica nanoparticles having near-infrared photothermal and in-vivo fluorescence imaging characteristics as well as preparation method and application of mesoporous silica nanoparticles
  • Multifunctional mesoporous silica nanoparticles having near-infrared photothermal and in-vivo fluorescence imaging characteristics as well as preparation method and application of mesoporous silica nanoparticles
  • Multifunctional mesoporous silica nanoparticles having near-infrared photothermal and in-vivo fluorescence imaging characteristics as well as preparation method and application of mesoporous silica nanoparticles

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Preparation of highly aminated mesoporous silica: Weigh 0.1g of cetyltrimethylammonium bromide (CTAB), heat and dissolve in 40mL of distilled water in a 150mL round bottom flask, then add 120μl of ethyl acetate and 50μl of ammonia water, quickly Stir for 30 minutes, slowly add 300 μl of tetraethyl orthosilicate (TEOS) and 97 mL of distilled water dropwise, and stir for 30 minutes; then, add 300 μl of aminopropyltriethylsilane (APTES), and continue stirring for 48 hours; the prepared Mesoporous silica nanoparticle dialysis, the dialysis time is 48 hours, the dialysis medium is a mixed solvent of ethanol (industrial alcohol), distilled water, and acetic acid with a volume ratio of 1:1:0.007, the container is 2000mL, and the solution is changed once. After the dialysis is completed, the obtained nanoparticle solution is concentrated by rotary evaporation, and the temperature of the rotary evaporation does not exceed 45° C., and the volume of the solution is reduced by half....

Embodiment 2

[0047] The amount of ammonia water used in the preparation of highly aminated mesoporous silica in Example 1 was reduced to 25 μl. The other steps are the same as in Example 1. Silicon nanoparticles with an average diameter of 30 nm can be prepared, and the size and particle size distribution of mesoporous silica nanoparticles can be adjusted by adjusting the amount of ammonia water.

Embodiment 3

[0049] The amount of cetyltrimethylammonium bromide used in the preparation process of highly aminated mesoporous silica in Example 1 was increased to 0.2 g. Other steps are the same as in Embodiment 1.

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Abstract

The invention discloses multifunctional mesoporous silica nanoparticles having near-infrared photothermal and in-vivo fluorescence imaging characteristics as well as a preparation method and an application of the mesoporous silica nanoparticles. Mesoporous silica nanoparticles subjected to amination are modified by carbocyanine dye Cypate, mesoporous channels are loaded with an antitumor drug, the mesoporous silica nanoparticles subjected to amination are prepared with CTAB (cetyltrimethylammonium bromide) as a surfactant and are mixed with the antitumor drug in a solution, so that the mesoporous channels are loaded with the drug, an obtained nano-drug carrier is applied to near-infrared photothermal treatment, near-infrared fluorescence imaging and delivery of the antitumor drug, multi-functionalization of the same nano-drug carrier is realized, the mesoporous silica nanoparticles have very good biocompatibility, and produced chemotherapy and photothermal treatment combined effect is better than that produced with single treatment method.

Description

technical field [0001] The invention relates to a multifunctional nano drug carrier and its preparation method and application, in particular to a multifunctional mesoporous silica nanoparticle with near-infrared photothermal and in vivo fluorescence imaging properties and its preparation method and application. Background technique [0002] Photothermal therapy is a local tumor treatment method that has developed rapidly in recent years. It uses exogenous photothermal molecules or carriers to enrich tumor sites, and produces photothermal effects under near-infrared light (650-900nm) illumination, thereby inducing acute necrosis and immune responses of tumors (Adv.Mater., 2013, 25:3869-3880; Nat. Rev. Cancer, 2014, 14:199-208; Theranostics, 2013, 3:152-166; Acc. Chem. Res., 2011, 44:947-956). As a minimally invasive treatment technique, photothermal therapy can effectively inhibit tumor growth and has attracted great attention. The development of materials with high photot...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K49/00A61K47/04A61K9/14A61K31/704A61K31/337A61K33/24A61P35/00
Inventor 陈华兵邓益斌杨红柯亨特黄丽朱爱军郭正清
Owner SUZHOU UNIV
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