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External patch containing anastrozole and application thereof

An anastrozole and patch technology, which is applied in the field of external preparations containing anastrozole, can solve problems such as drugs entering the human body, and achieve the effects of avoiding first-pass effect, good reproducibility and stable process

Inactive Publication Date: 2015-11-18
徐静 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to overcome the shortcoming of the prior art that anastrozole can not make the drug enter the human body at a nearly constant rate for a long time when treating breast cancer, and provide a long-acting, skin-absorbed, patient-adapted drug. An external patch containing anastrozole that is easy to carry and use

Method used

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  • External patch containing anastrozole and application thereof
  • External patch containing anastrozole and application thereof
  • External patch containing anastrozole and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Preparation of a skeleton-type external patch containing anastrozole:

[0035]

[0036] Prepare according to the following preparation process:

[0037] ① Dissolve anastrozole in ethyl acetate solution, add silicone rubber pressure-sensitive adhesive and mix well. ②Apply the mixed glue on the backing material with an area of ​​10000cm 2 , heated and dried, and then covered with a protective layer. ③ Cutting according to the required size, packaging, and then making a skeleton-type transdermal patch containing the pharmaceutical composition.

Embodiment 2

[0038] Example 2: Preparation of a skeleton-type external patch containing anastrozole:

[0039]

[0040] Prepare according to the following preparation process:

[0041] ① Dissolve Anastrozole in acetone solution, add acrylate pressure sensitive adhesive and mix well. ②Apply the mixed glue on the backing material with an area of ​​10000cm 2 , heated and dried, and then covered with a protective layer. ③ Cutting according to the required size, packaging, and then making a skeleton-type transdermal patch containing the pharmaceutical composition.

Embodiment 3

[0042] Example 3: Preparation of a skeleton-type external patch containing anastrozole:

[0043]

[0044] Prepare according to the following preparation process:

[0045] ① Dissolve anastrozole and glyceryl triacetate in dichloromethane solution, add acrylate pressure sensitive adhesive and mix well. ②Apply the mixed glue on the backing material with an area of ​​10000cm 2 , heated and dried, and then covered with a protective layer. ③ Cutting according to the required size, packaging, and then making a skeleton-type transdermal patch containing the pharmaceutical composition.

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Abstract

The invention relates to an external patch containing anastrozole and a preparation method thereof. The external preparation uses anastrozole as a main drug, and is used for treating breast cancer. The external patch containing anastrozole is absorbed in a percutaneous manner, is uniform in drug release and mild and durable in action. One patch can be continuously used for 7 days. The patch directly acts on skin without passing through gastrointestinal tracts, so that the first pass effect of liver can be avoided, adverse response is reduced, and the occurrence rate of adverse responses is reduced. The external patch has good patient compliance, and is convenient to use and carry.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a pharmaceutical preparation for external use, in particular to an external preparation containing anastrozole and its application. Background technique [0002] Anastrozole is a potent, selective non-steroidal aromatase inhibitor. It can inhibit the conversion of androstenedione produced in the adrenal gland of postmenopausal patients into estrone, thereby significantly reducing the plasma estrogen level and inhibiting the growth of breast tumors. In addition, anastrozole had no significant effect on corticosteroid or aldosterone production. [0003] Anastrozole is absorbed quickly after oral administration. About 40% of anastrozole is bound to plasma protein in the body, most of which are metabolized into inactive products and excreted through urine, and about 10% of anastrozole is excreted through urine in its original form. According to data ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/4196A61P35/00
Inventor 徐静张艳红杨洋徐光昳
Owner 徐静
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