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Lead-chelated immune compound, and preparation method and application of compound

An immune complex and chelation-type technology, applied in the field of detection of circulating immune complexes, can solve problems such as body damage, functional changes, and deficiencies

Inactive Publication Date: 2015-11-11
广东腾湃医疗股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But how does environmental pollution stimulate the body to significantly increase the CIC content? Is it caused by one or multiple pollutants? Whether the increase in CIC will cause damage to the body and increase the susceptibility of the body to diseases? all to be studied
Circulating immune complexes are proteins of special significance, and lead can act on proteins in multiple systems throughout the body. Whether lead can act on circulating immune complexes, resulting in changes in the content, activity, and function of circulating immune complexes, these There is still a lack of relevant research

Method used

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  • Lead-chelated immune compound, and preparation method and application of compound
  • Lead-chelated immune compound, and preparation method and application of compound
  • Lead-chelated immune compound, and preparation method and application of compound

Examples

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Embodiment 1

[0165] In this example, ITCBE was purchased from Japan Tongren Chemical Research Institute, item number M030;

[0166] The following borate buffer solution, its preparation method example: Weigh 0.31g boric acid and dissolve it in 400mLddH 2 In O, use 0.1mol / L NaOH aqueous solution to adjust the pH to 9.0, and set the volume to 500mL, to obtain;

[0167] The following EDTA-NaHCO 3 Solution preparation method example: take 1.86gEDTA·2H 2 O and 16.8 g NaHCO 3 , dissolved in 900mLddH 2 In O, adjust the pH to 8.0 with 1.0M NaOH and dilute to 1000mL, autoclave, and store at 25±2°C;

[0168] The following dialysis bags had a molecular weight cut-off of 14000 and were purchased from Bioshop Inc; the dialysis bags were processed as follows: the dialysis bags were placed in 500 mL volume of EDTA-NaHCO 3 solution, boil for 10min; discard EDTA-NaHCO 3 solution with ddH 2 Rinse with O, then boil with 500mL5mmol / LEDTA for 10min; discard the boiling liquid, thoroughly rinse with ddHO...

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Abstract

The invention provides a lead-chelated immune compound, and a preparation method and an application of the lead-chelated immune compound. The lead-chelated immune compound is one of the following compounds: a compound formed from an immune compound combined with lead ions, or a compound formed from carrier protein combined with lead and an antibody specifically binding to the carrier protein, or a compound formed from immune globulin combined with lead ions and carrier protein. The lead-chelated immune compound is an immune compound with relative specificity. Whether the lead-chelated immune compound is contained in serum of people in an area and the content of the compound is detected, so that the lead pollution degree in the area is indirectly reflected.

Description

technical field [0001] The invention relates to the detection of circulating immune complexes, in particular to a lead chelating immune complex. Background technique [0002] Immune complexes (IC) are the product of antigen-antibody binding. According to the definition of the National Committee for Scientific and Technical Terms, IC refers to the complex formed by the combination of antibody and soluble antigen. It is divided into two categories, one is the fixed immune complex in the tissue, and the other is the immune complex that is free in the blood and becomes the circulating immune complex (circulating immune complexes, CIC). The clearance of immune complexes depends to a large extent on the size of CIC, antibody type, relative concentration of antigen and antibody, etc. Only in a few cases, immune complexes precipitate and cause tissue damage and disease. The occurrence of various diseases is closely related to the deposition of immune complexes, such as systemic lup...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/96G01N33/68
CPCG01N33/6854G01N33/96
Inventor 张积仁阳帆董欣敏吴婧蔡睿孙遥赵乙木
Owner 广东腾湃医疗股份有限公司
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