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Opto-acoustic Doppler blood flow rate measurement method and system for determining oxygen content of red blood cells

A Doppler technology for blood and red blood cells, applied in diagnostic recording/measurement, medical science, sensors, etc., to achieve the effect of large detection depth and high resolution

Inactive Publication Date: 2015-11-11
NANKAI UNIV
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Problems solved by technology

[0007] At present, there is no photoacoustic technology that can simultaneously determine the blood oxygen content of red blood cells and accurately measure the blood flow velocity according to the Doppler effect.

Method used

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  • Opto-acoustic Doppler blood flow rate measurement method and system for determining oxygen content of red blood cells
  • Opto-acoustic Doppler blood flow rate measurement method and system for determining oxygen content of red blood cells
  • Opto-acoustic Doppler blood flow rate measurement method and system for determining oxygen content of red blood cells

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Embodiment Construction

[0039] Such as figure 1 As shown, it is a photoacoustic Doppler blood flow measurement system capable of discriminating the oxygen content of red blood cells according to the present invention. , 4, two converging lenses 5, 6, fiber coupler 7, three-dimensional precision translation stage 8, achromatic objective lens 9, converging lens 10, converging laser beam 11, blood vessel 12, ultrasonic transducer 13, three-dimensionally adjustable and fixed Support 14, signal amplifier 15, lock-in amplifier 16, computer 17.

[0040] Such as image 3 As shown, it is a schematic diagram of the photoacoustic Doppler power spectrum of black polystyrene particles under two-way laser excitation. It can be seen that two peaks are distributed on the left side of 5Hz and 15Hz respectively in the power spectrum. According to It can be inferred that the frequency shift is negative, that is, the blood is moving away from the ultrasonic transducer 13; the average photoacoustic Doppler frequency sh...

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Abstract

The invention discloses an opto-acoustic Doppler blood flow rate measurement method and a measurement system for determining oxygen content of red blood cells. According to the measurement system, multiple paths of laser beams coded by intensity modulation frequency and with different wavelengths focus and illuminate the same area of a blood vessel, and a lock-in amplifier is adopted for demodulating to obtain opto-acoustic Doppler frequency spectrum signals obtained by an ultrasonic transducer and positioned at different center frequencies. The measurement method and the measurement system have the characteristics that photoacoustic spectrometry of red blood cells change along with oxygen content, the flow rate and the flow direction of blood can be accurately determined, the oxygen content of blood also can be determined, so that arterial blood and venous blood can be distinguished. The measurement method and the measurement system can be used for researching blood microcirculation, and through the simultaneous detection on the flow rate of the blood and the oxygen content of the blood, the metabolism condition of the local tissue is obtained.

Description

technical field [0001] The invention belongs to a Doppler blood flow measurement method and its realization system. The measurement method makes full use of the multi-spectrum biological recognition characteristics of biomedical photoacoustic imaging, and can measure blood flow velocity distribution by applying the photoacoustic Doppler effect. Information about the oxygen content of red blood cells is also obtained. Background technique [0002] The photoacoustic effect refers to the phenomenon that when a light-absorbing substance is subjected to light of varying intensity, part of the light absorption is converted into heat, causing the substance to expand when heated, thereby radiating sound waves outward. [0003] The Doppler effect refers to the phenomenon that when the wave source of a certain frequency and the detector move relative to each other, the wave signal measured by the detector will shift in frequency. When the wave source and detector move in opposite dir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/0285A61B5/1455
Inventor 赵宏才方晖
Owner NANKAI UNIV
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