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Single-effect external-cycle concentrator and application thereof

An external circulation and concentrator technology, applied in evaporator accessories, chemical instruments and methods, peptide preparation methods, etc., can solve the problem of non-compliance with pharmaceutical production quality management standards, no online cleaning device, vapor/liquid separator condensation device, etc.

Active Publication Date: 2015-11-04
HEBEI ZHITONG BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese Invention Patent No. CN203281049U and CN202638005U provide a single-effect external circulation concentrator structure mainly including a heating chamber, an evaporation chamber, a cooler, and a liquid receiver, and none of them provide an online cleaning device, a vapor / liquid separator, or a condenser. Osteopeptide production equipment does not meet the requirements of the "Good Manufacturing Practice for Pharmaceutical Products" because there is no online cleaning device

Method used

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  • Single-effect external-cycle concentrator and application thereof
  • Single-effect external-cycle concentrator and application thereof
  • Single-effect external-cycle concentrator and application thereof

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0117] figure 1 It is a schematic cross-sectional structure diagram of the present invention; figure 2 is a schematic diagram of the top view structure;

[0118] A single-effect external circulation concentrator is characterized in that it includes a heating chamber 1, an evaporating chamber 2, a separator I4, a condenser 5, a cooler 6, a separator II7 and a liquid receiver 8.

[0119] The heating chamber 1 is fixed by the legs 70, the inside is the tubular heat exchanger structure I30 and the lower end has a material inlet and outlet 23, and the lower end on the left side of the heating chamber is equipped with a tube for leading out from the tubular heat exchanger structure I30. The heating medium outlet 12 of the heating medium is equipped with a heating medium inlet 11 for introducing the heating medium into the tube-and-tube heat exchanger structure I30 on the upper end of the left side. There are evenly distributed heating tubes in the heating chamber 1. 1 The lower e...

Embodiment 2

[0128] Such as figure 1 , figure 2 The heating chamber shown is the heating unit of the equipment. It is located on the left side of the equipment and is fixed by the outrigger (heating chamber). The inside is a shell and tube heat exchanger structure I, and the outside includes material inlet and outlet, heating medium outlet, heating medium inlet, The material circulation port, the spray ball I and the thermometer are equipped with a heating medium outlet for drawing the heating medium from the shell and tube heat exchanger structure I at the lower end of the left side of the heating chamber, and are equipped with a heating medium outlet at the upper end of the left side. The heating medium inlet of the heating medium is introduced into the shell and tube heat exchanger structure I, and the material circulation port is equipped at the lower end on the right side of the heating chamber, and the evaporation spraying steam of the evaporation chamber is connected to the upper e...

Embodiment 3

[0137] The production method of using a single-effect external circulation concentrator to concentrate and extract protein substances in animal tissues:

[0138] (1) Feeding: The liquid material is sent from the inlet and outlet of the material to the heating chamber and the evaporation chamber of the single-effect external circulation concentrator through nitrogen or vacuum suction, and in the process of decompression concentration, the liquid material can be sucked into the single-effect concentrator by vacuum. The method in the tank cavity of the external circulation concentrator is used to feed the material, and the volume of the liquid medicine is generally maintained at 200L during the concentration process

[0139] (2) Heating: The medicinal liquid inhaled into the heating chamber of the single-effect external circulation concentrator passes through the tubular heat exchanger structure I, and is heated to the required temperature or maintained during the evaporation...

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Abstract

The invention discloses a single-effect external-cycle concentrator and an application thereof. The single-effect external-cycle concentrator comprises a heating chamber 1, an evaporating chamber 2, a separator I 4, a condenser 5, a cooler 6, a separator II 7 and a liquid receiver 8. The heating chamber, the evaporating chamber and the separator I are equipped with online cleaning devices respectively. The single-effect external-cycle concentrator has the advantages of a simple structure, convenience in mounting and dismounting, high evaporating efficiency, capacity of realizing online cleaning and the like, is safe and reliable in a using process, and capable of removing an organic solvent in a bone peptide crude drug liquid better. External-cycle heating is adopted, so that the heated liquid is sprayed after entering the evaporating chamber through a steam vent, and therefore, the evaporating area is increased, the solvent is quickly evaporated, and the concentration time can be shortened. Alcohol residues of the bone peptide drug liquid produced by the single-effect external-cycle concentrator are less than 10mg / ml. The single-effect external-cycle concentrator has the characteristics that a process for producing a bone peptide crude drug is easy to control, the quality of the produced bone peptide crude drug is stable, and the organic solvent residues are less.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical machinery and equipment, and relates to a single-effect external circulation concentrator and its application. Background technique [0002] Osteopeptide occupies an important position in the medical field. It is mainly used to improve the symptoms of rheumatism, rheumatoid arthritis, osteoporosis, cervical spondylosis and other diseases. It is also used for bone healing after fractures and orthopedic operations, which can promote bone healing and bone healing. newborn. Osteopeptide is extracted from the limb bones of healthy pigs. The main components are small molecule peptides and protein peptides. The ingredients are soluble in water and 70% ethanol. During the extraction process, ethanol must be used for precipitation to remove insoluble precipitates. [0003] Chinese Invention Patent No. ZL201010000663.5 mentions that "take the concentrated solution, add 95% ethanol to a final concen...

Claims

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Application Information

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IPC IPC(8): B01D1/16B01D1/30B01D3/10C07K1/14
Inventor 齐兴忠张敏浦同骄何来鹏徐顺意陈润蒋素静刘云宇于扬徐军科许峰
Owner HEBEI ZHITONG BIOLOGICAL PHARMA
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