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Medical and antibacterial cationic biogel dressing and preparation method thereof

A bio-glue, cationic technology, applied in medical preparations containing active ingredients, antibacterial drugs, antifungal agents, etc., can solve the problems of inability to keep the wound surface moist, difficult to heal infected wounds, and poor ability to absorb exudate, etc. Achieve the effect of promoting wound healing, keeping the wound moist, and having strong antibacterial and anti-inflammatory effects

Active Publication Date: 2015-11-04
DONGGUAN DAQING MEDICAL DEVICES CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The advantages of this type of dressing are: certain absorbency, easy to make, cheap, and reusable; the disadvantages are: the inability to keep the wound moist leads to delayed wound healing, the dressing fibers are likely to cause foreign body reactions and affect healing, and the newborn is easily damaged when changing dressings. Tissues and pathogens are easy to pass through the soaked dressing, and the workload of changing the dressing is heavy, and the bacterial resistance caused by the local application of antibiotics in the gauze dressing makes it difficult to heal the infected wound
[0006] The Chinese invention patent with the publication number CN1320931C discloses a polyvinyl alcohol hydrogel dressing containing medicine and chitosan. This medical hydrogel dressing can be used to treat various skin wounds and burns, but it has the ability to absorb seepage Poor, there are disadvantages of harmful substances such as plasticizers remaining; the Chinese invention patent with the publication number CN102114265A discloses a medical dressing containing nano-silver and carboxymethyl chitosan, which has good antibacterial effect, but has the disadvantage of being unable to maintain the wound surface. Wet, resulting in delayed wound healing; not easy to uncover from the wound and other disadvantages; the Chinese invention patent with the publication number CN100471528C discloses a liquid (gel-like) wound dressing that promotes wound healing and antibacterial functions. The medical dressing has anti-inflammatory properties. It has the effect of relieving pain and promoting wound healing, but has the disadvantage of poor ability to absorb exudate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] A kind of cationic medical bio-glue antibacterial dressing, described cationic medical bio-glue antibacterial dressing is made up of the raw material of following percentage by weight:

[0089] Glycerin 2%

[0090] Chitosan quaternary ammonium salt 2%

[0091] Amino Iodine 0.5%

[0092] Silicone quaternary ammonium salt 0.3%

[0093] Folium Folium Extract 0.3%

[0094] Prunella vulgaris extract 0.3%

[0095] Xu Changqing Extract 0.3%

[0096] Purified water balance.

[0097] The chitosan quaternary ammonium salt is 92% 2-hydroxypropyltrimethylammonium chloride chitosan and quaternization degree 95% dimethyl diallyl ammonium chloride A mixture of chitosan with a weight ratio of 2.5:1.

[0098] The organosilicon quaternary ammonium salt is methyldiethoxysilane quaternary ammonium salt.

[0099] A preparation method of cationic medical bio-glue antibacterial dressing, comprising the steps of:

[0100] Step A, weighing: Weigh the glycerol, chitosan quaternary ammon...

Embodiment 2

[0104] A kind of cationic medical bio-glue antibacterial dressing, described cationic medical bio-glue antibacterial dressing is made up of the raw material of following percentage by weight:

[0105] Glycerin 2.5%

[0106] Chitosan quaternary ammonium salt 2.5%

[0107] Amino Iodine 0.8%

[0108] Silicone quaternary ammonium salt 0.4%

[0109] Folium Folium Extract 0.4%

[0110] Prunella vulgaris extract 0.4%

[0111] Xu Changqing Extract 0.4%

[0112] Purified water balance.

[0113] The chitosan quaternary ammonium salt is 93% 2-hydroxypropyltrimethylammonium chloride chitosan and 96% dimethyl diallyl ammonium chloride by quaternization degree A mixture of chitosan with a weight ratio of 2.8:1.

[0114] The organosilicon quaternary ammonium salt is N,N-dimethyl-N-octadecylaminopropyltrimethoxysilane quaternary ammonium salt.

[0115] A preparation method of cationic medical bio-glue antibacterial dressing, comprising the steps of:

[0116] Step A, weighing: Weigh t...

Embodiment 3

[0120] A kind of cationic medical bio-glue antibacterial dressing, described cationic medical bio-glue antibacterial dressing is made up of the raw material of following percentage by weight:

[0121] Glycerin 3%

[0122] Chitosan quaternary ammonium salt 3%

[0123] Amino Iodine 1%

[0124] Silicone quaternary ammonium salt 0.5%

[0125] Folium Folium Extract 0.5%

[0126] Prunella vulgaris extract 0.5%

[0127] Xu Changqing Extract 0.5%

[0128] Purified water balance.

[0129] The chitosan quaternary ammonium salt is 94% 2-hydroxypropyltrimethylammonium chloride chitosan and quaternization degree 97% dimethyl diallyl ammonium chloride A mixture of chitosan with a weight ratio of 3:1.

[0130] The organosilicon quaternary ammonium salt is polysiloxane quaternary ammonium salt.

[0131] The polysiloxane quaternary ammonium salt is trimethylsilyl-terminated polydimethylsiloxane quaternary ammonium salt.

[0132] A preparation method of cationic medical bio-glue antiba...

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PUM

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Abstract

The invention relates to the technical field of medical dressing, in particular to medical and antibacterial cationic biogel dressing and a preparation method thereof. The medical and antibacterial cationic biogel dressing comprises raw materials in percentage by weight as follows: glycerin, chitosan quaternary ammonium salt, amino-acid iodine, organosilicon quaternary ammonium salt, an indigowoad leaf extraction solution, a prunella vulgaris extraction solution, a paniculate swallowwort root extraction solution and the balance of purified water. The antibacterial dressing has a remarkable antibacterial effect, is transparent, high in water content, non-toxic, harmless, nonirritating and good in biocompatibility and adhesion, can isolate bacteria, kill bacteria, fungi and viruses and prevent skin and mucous membranes from infection, can stop bleeding and keep the wound wet and further can promote skin regeneration and healing of the wound. The medical and antibacterial cationic biogel dressing can be widely used for preventing and treating infection of skin wound such as skin bruise, scalding, burning, bedsore, ulcer, vagina skin eczema and the like and local mucous membrane infection of an oral cavity, the throat, gingivae and the like and can relieve pains, inhibit bacteria, protect wound, promote wound healing and inhibit scarring.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to a cationic medical biological glue antibacterial dressing and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body, and it is a natural barrier to maintain the stability of the internal environment and prevent the invasion of microorganisms; however, the large area exposed to the outside world makes the skin vulnerable to external injuries such as burns and mechanical injuries. Because Staphylococcus aureus, Escherichia coli and other pathogens multiply on the wound, it is easy to cause wound infection; the infected wound is not easy to heal, and it is easy to cause loss of body fluid and various complications. [0003] Gauze-type dressings, known as traditional dressings, are generally made from cotton, burlap, and linen. This type of dressing has the strongest practicability, the greatest influence, and the longe...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44A61L15/42A61K9/06A61K36/704A61K36/536A61K36/855A61P17/02A61P9/14A61P1/02A61P15/02A61P31/04A61P31/10A61P31/12A61K31/722A61K33/18
Inventor 梁奕福
Owner DONGGUAN DAQING MEDICAL DEVICES CO LTD
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