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Application of calcium poly-malate in the preparation of feed acidifier

A feed acidifier, calcium malate technology, applied in application, animal feed, animal feed, etc., can solve the problems of inability to inhibit the growth of harmful microorganisms, inability to effectively reduce the pH value of the small intestine, and increase the production cost of acidifiers, achieving significant Anti-stress effect, improve disease resistance, improve pH and microenvironment effect

Active Publication Date: 2015-11-04
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the use of the two types of acidifiers, they are easily neutralized by alkali and lose their acidifying effect. They both have disadvantages such as rapid release and absorption in the stomach. The added acid usually cannot reach the small intestine of livestock and poultry, and cannot effectively reduce the pH value in the small intestine. Can not achieve the purpose of inhibiting the growth of harmful microorganisms and promoting the growth of beneficial bacteria
[0004] In order to realize the slow release of acidifiers in the intestinal tract, slow-release acidifiers have been developed in recent years, such as a preparation method of a slow-release compound acidifier for pigs (patent application number 201310633389.9), a slow-release acidifier for feeding intestines Composite acidifier and its preparation method (patent application number 201410609157.4), etc. However, the production process of this kind of slow-release acidifier needs to add microencapsulated materials, and it is prepared through spraying, granulation, drying and other processes. Compared with composite acidifier, A large amount of production equipment and slow-release materials need to be invested, which greatly increases the production cost of the acidifier
In addition, in order to improve the production quality of livestock and poultry breeding, for example, a large amount of inorganic calcium carbonate is usually added to the feed as a calcium supplement in laying hen breeding, which may easily lead to problems such as diarrhea, feed intake and survival rate of livestock and poultry.

Method used

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  • Application of calcium poly-malate in the preparation of feed acidifier
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  • Application of calcium poly-malate in the preparation of feed acidifier

Examples

Experimental program
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Effect test

Embodiment 1

[0020] The method for preparing calcium polymalate, comprises the steps:

[0021] (1) Strain seed culture: Aureobasidium pullulans (Aureobasidium pullulans) with the preservation number of CCTCC NO: M 2012223 was inoculated in a shake flask containing 50 mL of seed medium (the volume of the shake flask was 500 mL), and the temperature was 25 ° C. , cultivated for 48 hours under the condition of 220 rpm;

[0022] (2) Polymalic acid fermentation: take the culture solution of step (1) and inoculate it in a 300L fermenter containing 220L fermentation medium according to the inoculum size of 10%, and then inoculate it at a temperature of 25°C and an aeration ratio of 1:1 (v / v) or above, and the residual sugar concentration is above 20g / L, ferment for 144 hours, and add CaCO during the fermentation process 3 Solution control pH is 6.0; Detect polycalcium malate output after fermentation, the result shows that the output of present embodiment polycalcium malate is 156g / L;

[0023]...

Embodiment 2

[0027] The method for preparing calcium polymalate, comprises the steps:

[0028] (1) Strain seed culture: Aureobasidium pullulans (Aureobasidium pullulans) with the preservation number of CCTCC NO: M 2012223 was inoculated in a shake flask containing 50 mL of seed medium (the volume of the shake flask was 500 mL), and the temperature was 25 ° C. , cultivated for 48 hours under the condition of 220 rpm;

[0029] (2) polymalic acid fermentation: the culture solution of step (1) is inoculated in a 300L fermenter containing 220L fermentation medium by 10% of the inoculum size, and then the temperature is 25°C and the aeration ratio is 1:1.2 (v / v) or above, and the residual sugar concentration is above 20g / L, ferment for 150 hours, and add CaCO during the fermentation process 3 Solution control pH is 5.5; Detect polycalcium malate output after fermentation, the result shows that the output of present embodiment polycalcium malate is 167g / L;

[0030] (3) extract calcium polymala...

Embodiment 3

[0037] Effect of feeding piglets with polycalcium malate compound additive

[0038] 16 healthy weaned piglets were selected and divided into 4 treatments, each treatment had 4 replicates, and each replicate had 1 weaned piglet. The average weaning age of piglets was 21 days, and the average weaning weight was 8.01±0.21kg. There was no significant difference in the initial weight of weaned piglets among the treatments (P>0.01). With reference to China (2004) "Nutritional Requirements of Pigs", it is formulated without calcium carbonate (CaCO 3 ) corn-soybean meal based diet. The content of Ca in the basal diet was 0.63%, and the Ca requirement of piglets in the 8-20kg stage was set at 0.88%. The experimental treatment was set as the inorganic calcium group, adding calcium carbonate (CaCO 3 : the amount of Ca38%) is (0.88-0.63) / 0.38=0.66%, total calcium content 0.88% in the diet; 100% calcium organic acid group (calcium polymalate provides calcium source), add the amount of c...

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Abstract

The present invention discloses an application of calcium poly-malate in the preparation of feed acidifier. The application uses the slow-release properties of the calcium poly-malate, which will be decomposed to produce malic acids and gradually release the malic acids from stomach tissues of livestock to small intestines to improve intestinal pH and micro environment. At the same time, the carried organic calcium is beneficial for intestinal absorption, and the livestock and poultry feeding trials showed that the added calcium poly-malate compound feed additives can effectively improve the intestinal flora of piglets, laying hens or table poultry, and significantly increase feed intake, and the calcium use is more efficient than inorganic calcium. Meanwhile, the application of the calcium poly-malate in piglets has an obvious anti-stress effect and can enhance disease resistance of piglets and meat quality of pigs; the application in laying hens can improve production performance and egg quality of laying hens; and the application in table poultry can also improve growth performance of table poultry and can improve growth performance of livestock and poultry.

Description

technical field [0001] The invention belongs to the field of biological feed, and in particular relates to the application of polycalcium malate in preparing feed acidifiers. Background technique [0002] Polymalic acid (PMA) is fermented and produced by Aureobasidium pullulans. It is polymerized in vivo with L-malic acid as the only monomer. It is a new type of fully biodegradable polymer material. As an aliphatic polyester, PMLA has the advantages of high biocompatibility, biodegradability, bioabsorbability, safety and non-toxicity. In addition, the polymerized monomer of polymalic acid is L-malic acid. Compared with citric acid, malic acid has the characteristics of high acidity, soft taste and long residence time. It is an excellent acidifier for livestock and poultry. [0003] Sour agent is a substance that can acidify the feed and increase the acidity of the immature digestive tract of young livestock and poultry. Studies have shown that the use of acidifiers can red...

Claims

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Application Information

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IPC IPC(8): A23K1/16
Inventor 邹祥陈力苏军冯骏
Owner SOUTHWEST UNIVERSITY
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