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Skin epidermis repairing material and preparation method thereof

A technology of epidermis repair and porous composite materials, which is applied in the field of skin epidermis repair materials and its preparation, can solve problems such as the difficulty of skin epidermis repair, achieve the effect of no health risks and promote regeneration

Inactive Publication Date: 2015-10-21
SUZHOU JONATHAN NEW MATERIALS TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Technical problem to be solved: the present invention provides a skin epidermis repair material and its preparation method to solve the difficulties in skin epidermis repair in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A material for repairing the skin epidermis, which is mainly made of the following raw materials according to the ratio of parts by mass: 12 parts of keratin, 13 parts of keratin, 8 parts of basophilic transparent keratin particles, 1 part of melanin particles, and 12 parts of aminodextran 8 parts of hyaluronic acid, 6 parts of chitosan, 1 part of fibronectin, and 30 parts of deionized water.

[0030] A preparation method of a skin epidermis repair material, comprising the following steps:

[0031] (1) Dissolving keratin and fibronectin in deionized water, heating to 22°C to make slurry 1; depositing slurry 1 in a mold, and cooling to the temperature at which slurry 1 transforms into multiple crystals or particles;

[0032] (2) heating the crystals or particles obtained in step (1) to 59°C to obtain porous composite material 1, and taking the material out of the mold;

[0033] (3) Dissolve keratin, melanin particles, basophilic transparent keratin particles and hyaluro...

Embodiment 2

[0036] A material for repairing the skin epidermis, which is mainly made of the following raw materials according to the ratio of parts by mass: 26 parts of keratin, 21 parts of keratin, 18 parts of basophilic transparent keratin particles, 5 parts of melanin particles, and 22 parts of aminodextran 19 parts of hyaluronic acid, 21 parts of chitosan, 6 parts of fibronectin, and 48 parts of deionized water.

[0037] A preparation method of a skin epidermis repair material, comprising the following steps:

[0038] (1) Dissolving keratin and fibronectin in deionized water, heating to 28°C to make slurry 1; depositing slurry 1 in a mold, cooling to the temperature at which slurry 1 transforms into multiple crystals or particles;

[0039] (2) heating the crystals or particles obtained in step (1) to 72°C to obtain the porous composite material 1, and taking the material out of the mold;

[0040] (3) Dissolve keratin, melanin particles, basophilic transparent keratin particles and hy...

Embodiment 3

[0043] A material for repairing the skin epidermis, which is mainly made of the following raw materials according to the ratio of parts by mass: 30 parts of keratin, 25 parts of keratin, 25 parts of basophilic transparent keratin particles, 8 parts of melanin particles, and 30 parts of aminodextran 25 parts of hyaluronic acid, 26 parts of chitosan, 9 parts of fibronectin, and 55 parts of deionized water.

[0044] A preparation method of a skin epidermis repair material, comprising the following steps:

[0045] (1) Dissolving keratin and fibronectin in deionized water, heating to 32°C to make a slurry 1; depositing the slurry 1 in a mold, and cooling to a temperature at which the slurry 1 transforms into multiple crystals or particles;

[0046] (2) heating the crystals or particles obtained in step (1) to 78°C to obtain the porous composite material 1, and taking the material out of the mold;

[0047] (3) Dissolve keratin, melanin particles, basophilic transparent keratin partic...

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Abstract

The invention discloses a skin epidermis repairing material and a preparation method thereof. The skin epidermis repairing material is mainly prepared from, by mass, 12-30 parts of keratin, 13-25 parts of eleidin, 8-25 parts of basophilia keratohyalin granules, 1-8 parts of melanin grains, 12-30 parts of glycosaminoglycans, 8-25 parts of hyaluronic acid, 6-26 parts of chitosan, 1-9 parts of fibronectin and 30-55 parts of deionized water. Compared with the prior art, the skin epidermis repairing material and the preparation method thereof have the advantages that by means of the prepared skin epidermis repairing material, the clinical requirements can be met, high fusion performance with human epidermis is achieved, and regeneration of the skin epidermis can be rapidly facilitated; in addition, toxic and side effects do not occur, use is safe, and healthy hidden troubles do not exist.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a skin epidermis repair material and a preparation method thereof. Background technique [0002] Skin refers to the tissue on the surface of the body that covers the muscles. It is the largest organ in the human body and mainly undertakes functions such as protecting the body, perspiration, and feeling cold, heat, and pressure. The skin covers the whole body, and it protects various tissues and organs in the body from physical, mechanical, chemical and pathogenic microorganisms. The skin of humans and higher animals consists of three layers: epidermis, dermis (mesoderm), and subcutaneous tissue. [0003] The total weight of the skin accounts for 5-15% of the body weight, with a total area of ​​1.5-2 square meters, and a thickness of 0.5-4 mm, which varies from person to person or part of the body. The skin covers the whole body, and it protects various tissues and organs in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/60A61L27/22A61L27/20A61L27/56
Inventor 吕少波李卓才李苏杨
Owner SUZHOU JONATHAN NEW MATERIALS TECH
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