Meloxicam soluble powder for livestock and poultry and preparation method thereof

A technology of soluble powder and meloxicam, applied in non-central analgesics, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of no soluble powder research and patent reports, etc. Achieve good therapeutic effect, reasonable formula, shorten the course of disease

Inactive Publication Date: 2015-10-21
HENAN AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are foreign patents on meloxicam water-soluble granules and oral liquid, and there are domestic patents on tablets and sustained-release preparations, but there are no researches and patent reports on soluble powders at home and abroad.

Method used

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  • Meloxicam soluble powder for livestock and poultry and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A kind of 0.2wt% meloxicam soluble powder for livestock and poultry 100g, is made up of following raw materials: meloxicam 0.2g, meglumine 1.0g, sodium carbonate 2.5g, PVP k30 1.0g, EDTA-2Na 2.0g, Sweetener 0.1g, flavoring agent 0.8g, and the balance is oral sugar.

[0031] The preparation method of meloxicam soluble powder for livestock and poultry of this embodiment comprises the following steps:

[0032] (1) Stir and mix meloxicam and basic organic co-solvent first, then add it to basic inorganic co-solvent, stir and mix evenly to obtain mixture A;

[0033] (2) Stir and mix the polymer solubilizer, ion complexing agent, flavoring agent, and sweetener evenly to obtain mixture B;

[0034] (3) Stir and mix the mixture A and the mixture B evenly to obtain the mixture C;

[0035] (4) Add the mixture C to the auxiliary material, stir and mix evenly at room temperature to obtain the mixture D;

[0036] (5) Pass the mixture D through a 60-80 mesh sieve, and pack in 50-100...

Embodiment 2

[0038] A 0.4wt% meloxicam soluble powder for livestock and poultry 100g, consisting of the following raw materials: 0.6g meloxicam meglumine, 3.0g potassium carbonate, 3.0g PEG6000, 3.0g sodium tripolyphosphate, sweetener 0.5g, flavoring agent 0.5g, and the balance is baking soda.

[0039] The preparation method of meloxicam soluble powder for livestock and poultry of this embodiment comprises the following steps:

[0040] (1) Add the basic salt of meloxicam to the basic inorganic co-solvent, stir and mix evenly to obtain mixture A;

[0041] (2) Stir and mix the polymer solubilizer, ion complexing agent, flavoring agent, and sweetener evenly to obtain mixture B;

[0042] (3) Stir and mix the mixture A and the mixture B evenly to obtain the mixture C;

[0043] (4) Add the mixture C to the auxiliary material, stir and mix evenly at room temperature to obtain the mixture D;

[0044] (5) Pass the mixture D through a 60-80 mesh sieve, and pack in 50-1000 g to obtain meloxicam so...

Embodiment 3

[0046]A 0.4wt% meloxicam soluble powder for livestock and poultry 100g, consisting of the following raw materials: 0.4g meloxicam, 2.5g meglumine (11.2 times the molar weight of meloxicam), 3.0g potassium carbonate, PEG6000 3.0g, sodium tripolyphosphate 3.0g, sweetener 0.5g, flavoring agent 0.5g, and the balance is anhydrous glucose.

[0047] The preparation method of meloxicam soluble powder for livestock and poultry of this embodiment comprises the following steps:

[0048] (1) Stir and mix meloxicam and basic organic co-solvent first, then add it to basic inorganic co-solvent, stir and mix evenly to obtain mixture A;

[0049] (2) Stir and mix the polymer solubilizer, ion complexing agent, flavoring agent, and sweetener evenly to obtain mixture B;

[0050] (3) Stir and mix the mixture A and the mixture B evenly to obtain the mixture C;

[0051] (4) Add the mixture C to the auxiliary material, stir and mix evenly at room temperature to obtain the mixture D;

[0052] (5) Pa...

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Abstract

The invention relates to meloxicam soluble powder for livestock and poultry and a preparation method thereof. The soluble powder comprises the following raw materials in percentage by weight: 0.1 to 1.2 percent of meloxicam basic salt, or 0.1 to 0.8 percent of meloxicam and an alkaline organic solvent with 1.5 to 20.0 times of the molar weight of the meloxicam, 1 to 8 percent of alkaline inorganic co-solvent, 0.5 to 7 percent of polymer solubilizer, 0.5 to 4 percent of ion complexing agent, 0.1 to 0.8 percent of flavoring agent, 0.1 to 0.8 percent of sweetening agent and the balance of auxiliary materials. The invention develops a novel formula of meloxicam suitable for groups, and the meloxicam soluble powder is good in water solubility, stable, low in production and application cost, and convenient in package and transportation.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a meloxicam soluble powder for livestock and poultry and a preparation method thereof. Background technique [0002] With the development of my country's animal husbandry and the expansion of breeding scale, infectious diseases such as bacteria, mycoplasma, and viruses often occur, and most of them are accompanied by inflammatory symptoms such as fever and pain. Therefore, at the same time as antibacterial and anti-mycoplasma drug treatment, auxiliary antipyretic, analgesic, anti-inflammatory and other symptomatic treatment methods can quickly relieve and control clinical symptoms, effectively reduce mortality, accelerate the recovery of sick animals, shorten the course of treatment, and achieve The purpose of governing. [0003] Meloxicam is a non-steroidal anti-inflammatory drug with good antipyretic, analgesic and anti-inflammatory effects. It is wide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/5415A61K47/34A61K47/32A61K47/18A61K47/24A61K47/12A61K47/04A61P29/00
Inventor 胡涵胡功政杜林丁美辉宋笑颜
Owner HENAN AGRICULTURAL UNIVERSITY
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