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Pharmaceutical composition for preventing recurrence and metastasis of gastrointestinal tumors, and preparation method and application thereof

A technology for gastrointestinal tumors, recurrence and metastasis, which is applied in the field of pharmaceutical compositions for preventing and treating recurrence and metastasis of gastrointestinal tumors and the field of preparation thereof, and can solve the problems of incompatibility with the recovery of the physiological characteristics of the digestive tract and unsatisfactory effects.

Inactive Publication Date: 2015-10-07
花宝金
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, from the analysis of the prescriptions of these Chinese patent medicines, the characteristics of these medicines are not in line with the physiological characteristics of restoring the digestive tract, and the effect in the maintenance treatment of digestive tract tumors, that is, the prevention of tumor recurrence and metastasis is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 3

[0083] A 58-year-old male patient was admitted to Beijing Shijitan Hospital affiliated to Capital Medical University in February 2010 due to "intermittent abdominal distension, blood in the stool, and fatigue for more than 3 months". object, occupying 2 / 3 of the intestinal cavity, and the mirror body barely passes through.” Pathological tip: moderately differentiated adenocarcinoma. He was admitted to the hospital and underwent laparoscopic radical resection of colon cancer, and the postoperative pathology showed: "(colonic splenic flexure) elevated moderately differentiated adenocarcinoma, with a size of 4 × 3 × 1.5 cm, infiltrating the muscle layer to the serosa, vascular tumor thrombus, intestinal Peripheral lymph node 3 / 18, T3N1M0, stage IIIB". Postoperative chemotherapy with FOLFOX4 regimen has completed 3 cycles. For further traditional Chinese medicine treatment, he came to see a doctor.

[0084] At the first visit on May 8, 2013, the patient had immediate symptoms: f...

Embodiment 1

[0088] Example 1: Shuangshen Jiedu Tablets

[0089] Take 6 parts of American ginseng, 9 parts of Panax notoginseng, 10 parts of Pinellia, 15 parts of Scutellaria baicalensis, 10 parts of Coptis chinensis, 6 parts of ginseng, 6 parts of dried ginger, 9 parts of licorice, 10 parts of jujube, 30 parts of snakeberry, 30 parts of vine pear root decocted with water for 3 times, the amount of water added was 4, 6, and 8 times the amount of water, respectively, and the decocting time was 1.5, 1.5, and 2 hours, respectively, combined the decoction, filtered, and concentrated to a relative density of 1.10 (60 ° C) 30% microcrystalline cellulose and 45% lactose by weight of the extract powder were added according to the equal amount incremental method, mixed evenly, and directly compressed into tablets.

Embodiment 2

[0090] Embodiment 2: Shuangshenjiedu soft capsule

[0091] Take 1 part of American ginseng, 6 parts of Panax notoginseng, 10 parts of Pinellia sinensis, 10 parts of Scutellaria baicalensis, 10 parts of Coptis chinensis, 6 parts of ginseng, 6 parts of dried ginger, 9 parts of licorice, 10 parts of jujube, 30 parts of snakeberry, 30 parts of vine pear root For the first time, add 6 times the amount of water, and cook for 1.5 hours; for the second time, add 8 times the amount of water, and cook for 2 hours. Combine the decoctions, filter, and concentrate to a relative density of 1.15. (60°C) extract, spray drying, add 20% soybean oil by weight of extract powder at 60°C, 20% polyethylene glycol 2000, 5% beeswax, mix well, put into soft capsule production filling machine Medium-pressure pills, screening, that is.

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PUM

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Abstract

The invention relates to a pharmaceutical composition for preventing recurrence and metastasis of gastrointestinal tumors. The pharmaceutical composition is prepared from the following bulk drugs in parts by weight: 1 to 6 parts of American ginseng, 6 to 12 parts of pseudo-ginseng root, 6 to 30 parts of pinellia tuber, 9 to 30 parts of baikal skullcap root, 6 to 30 parts of coptis root, 1 to 6 parts of ginseng, 6 to 9 parts of dried ginger, 6 to 12 parts of liquoric root, 5 to 12 parts of Chinese date, 10 to 30 parts of Indian strawberry and 10 to 30 parts of Chinese actinidia root. The invention also provides a preparation method and application of the pharmaceutical composition. According to the pharmaceutical composition, the recurrence and the metastasis of the gastrointestinal tumors can be effectively prevented, and the health quality of a patient is improved.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for preventing and treating the recurrence and metastasis of digestive tract tumors, and a preparation method and application thereof. Background technique [0002] Malignant tumors are still the main diseases that endanger human health and cause death. Gastrointestinal tumors are common tumor types, including esophageal cancer, gastric cancer, intestinal cancer, etc. About 2 / 3 of gastric cancer patients are in developing countries, of which China accounts for 42%. The incidence of esophageal cancer is obviously regional, and its high incidence areas include Asia (especially China, Singapore and Iran), southeastern Africa and northern France. The incidence of colorectal cancer varies widely around the world. In North America, Australia, New Zealand, Northern Europe, and Western European countries, colorectal cancer occupies the first and second place i...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P35/00
Inventor 花宝金刘瑞郑红刚李丛煌鲍艳举施展秦英刚
Owner 花宝金
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